33期

最新文章

• Integral feedback control is at the core of task allocation and resilience of insect societies (vol 115, pg 13180, 2018) AI翻译
  作者：Schmickl, Thomas; Karsai, Istvan
• Structural basis for DNA recognition by a viral genome-packaging machine AI翻译
  作者：Chechik, Maria; Greive, Sandra J.; Antson, Alfred A.; Jenkins, Huw T.
  作者单位：University of York - UK; University of York - UK
  摘要：DNA recognition is critical for assembly of double-stranded DNA viruses, particularly for the initiation of packaging the viral genome into the capsid. The key component that recognizes viral DNA is the small terminase protein. Despite prior studies, the molecular mechanism for DNA recognition remained elusive. Here, we address this question by identifying the minimal site in the bacteriophage HK97 genome specifically recognized by the small terminase and determining the structure of this comp...
• Formation of human kinship structures depending on population size and cultural mutation rate AI翻译
  作者：Itao, Kenji; Kaneko, Kunihiko
  作者单位：University of Tokyo; RIKEN; Max Planck Society; University of Copenhagen; Niels Bohr Institute; University of Tokyo
  摘要：How does social complexity depend on population size and cultural transmission? Kinship structures in traditional societies provide a fundamental illustration, where cultural rules between clans determine people's marriage possibilities. Here, we propose a simple model of kinship interactions that considers kin and in-law cooperation and sexual rivalry. In this model, multiple societies compete. Societies consist of multiple families with different cultural traits and mating preferences. These...
• H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1 AI翻译
  作者：Tang, Ruijun; Zhou, Mengqi; Chen, Yuwei; Jiang, Zhenghui; Fan, Xunan; Zhang, Jingheng; Dong, Aiping; Lv, Lu; Mao, Song; Chen, Fang; Gao, Guanjun; Min, Jinrong; Liu, Ke; Yuan, Kai
  作者单位：Central South University; Central South University; Central China Normal University; University of Toronto; Structural Genomics Consortium; Central South University; ShanghaiTech University; Central South University
  摘要：Constitutive heterochromatin, a fundamental feature of eukaryotic nucleus essential for transposon silencing and genome stability, is rebuilt on various types of repetitive DNA in the zygotic genome during early embryogenesis. However, the molecular program underlying this process remains poorly understood. Here, we show that histone H3 lysine 14 acetylation (H3K14ac) is engaged in the reinstallation of constitutive heterochromatin in Drosophila early embryos. H3K14ac partially colocalizes wit...
• Taking a closer look at the synapse AI翻译
  作者：Dittman, Jeremy S.
  作者单位：Cornell University; Weill Cornell Medicine
• Naturally occurring horse model of miscarriage reveals temporal relationship between chromosomal aberration type and point of lethality AI翻译
  作者：Lawson, Jessica M.; Salem, Shebl E.; Miller, Donald; Kahler, Anne; Boer, Wilhelmina J. van den; Shilton, Charlotte A.; Sever, Tia; Mouncey, Rebecca R.; Ward, Jenna; Hampshire, Daniel J.; Foote, Alastair K.; Bryan, Jill S.; Juras, Rytis; Pynn, Oliver D.; Davis, Brian W.; Bellone, Rebecca R.; Raudsepp, Terje; de Mestre, Amanda M.
  作者单位：University of London; University of London Royal Veterinary College; Cornell University; Texas A&M University System; Texas A&M University College Station; University of California System; University of California Davis; University of California System; University of California Davis
  摘要：Chromosomal abnormalities are a common cause of human miscarriage but rarely reported in any other species. As a result, there are currently inadequate animal models available to study this condition. Horses present one potential model since mares receive intense gynecological care. This allowed us to investigate the prevalence of chromosomal copy number aberrations in 256 products of conception (POC) in a naturally occurring model of pregnancy loss (PL). Triploidy (three haploid sets of chrom...
• Lining the small intestine with mycobacteriophages protects from Mycobacterium avium subsp. paratuberculosis and eliminates fecal shedding AI翻译
  作者：McKenna, Victoria K. Harman-; Eshraghisamani, Razieh; Shafer, Natali; De Buck, Jeroen
  作者单位：University of Calgary
  摘要：Johne's disease (JD), a chronic, infectious enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP), affects wild and domestic ruminants. There is no cure or effective prevention, and current vaccines have substantial limitations, leaving this disease widespread in all substantial dairy industries causing economic, and animal welfare implications. Mycobacteriophages (MPs) have been gaining interest in recent years and are proposed as a promising solution to curtailing MAP infecti...
• Structure-driven development of a biomimetic rare earth artificial metalloprotein AI翻译
  作者：Thompson, Peter J.; Boggs, David G.; Wilson, Charles A.; Bruchs, Austin T.; Velidandla, Uditha; Bridwell-Rabb, Jennifer; Olshansky, Lisa
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Michigan System; University of Michigan; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：The 2011 discovery of the first rare earth-dependent enzyme in methylotrophic Methylobacterium extorquens AM1 prompted intensive research toward understanding the unique chemistry at play in these systems. This enzyme, an alcohol dehydrogenase (ADH), features a La3+ ion closely associated with redox- active coenzyme pyrroloquinoline quinone (PQQ) and is structurally homologous to the Ca2+- dependent ADH from the same organstructurally characterized to 1.46- & Aring; resolution by X- ray diffra...
• Geological evidence reveals a staircase pattern in Earth's rotational deceleration evolution AI翻译
  作者：Huang, He; Ma, Chao; Laskar, Jacques; Sinnesael, Matthias; Farhat, Mohammad; Hoang, Nam H.; Gao, Yuan; Zeeden, Christian; Zhong, Hanting; Hou, Mingcai; Wang, Chengshan
  作者单位：Chengdu University of Technology; Chengdu University of Technology; Ministry of Natural Resources of the People's Republic of China; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Observatoire de Paris; Sorbonne Universite; Trinity College Dublin; China University of Geosciences; Leibniz Institut fur Angewandte Geophysik (LIAG)
  摘要：The Earth's rotation has been decelerating throughout its history due to tidal dissipation, but the variation of the rate of this deceleration through time has not been established. We present a detailed analysis of eight geological datasets to constrain the Earth's rotational history from 650 to 240 Mya. The results allow us to test physical tidal models and point to a staircase pattern in the Earth's deceleration from 650 to 280 Mya. During this time interval, the Earth-Moon distance increas...
• UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma AI翻译
  作者：Su, Wenjuan; Rossi, Juan Kochen; Nuevo-Tapioles, Cristina; Chen, Ting; Kawaler, Emily; Branco, Cristina; Wong, Kwok-kin; Simeone, Diane M.; Gardner, Lawrence B.; Philips, Mark R.
  作者单位：University of California System; University of California San Diego
  摘要：Upstream frameshift 1 (UPF1) is an RNA helicase involved in a number of mRNA regulatory processes including nonsense- mediated decay. Mutations in the UPF1 locus that reduce its expression have been associated with adenosquamous carcinoma of the pancreas, a particularly aggressive form of the disease. To determine the effect of Upf1 suppression in a murine model of pancreatic adenocarcinoma, we silenced with shRNA Upf1 in cells derived from an autochthonous tumor in an LSL- Kras G12D/+ ; Trp53...