36期

最新文章

• The deubiquitinase Usp7 in Drosophila melanogaster is required for synaptonemal complex maintenance AI翻译
  作者：Lake, Cathleen M.; Gardner, Jennifer; Briggs, Salam; Yu, Zulin; McKown, Grace; Hawley, R. Scott
  作者单位：Stowers Institute for Medical Research; University of Kansas; University of Kansas Medical Center
  摘要：Meiosis is a form of cell division that is essential to sexually reproducing organisms and is therefore highly regulated. Each event of meiosis must occur at the correct developmental stage to ensure that chromosomes are segregated properly during both meiotic divisions. One unique meiosis- specific structure that is tightly regulated in terms of timing of assembly and disassembly is the synaptonemal complex (SC). While the mechanism(s) for assembly and disassembly of the SC are poorly underst...
• Demographic drivers of reproductive failure in a threatened bird: Insights from a decade of data AI翻译
  作者：Morland, Fay; Ewen, John G.; Santure, Anna W.; Brekke, Patricia; Hemmings, Nicola
  作者单位：University of Sheffield; Zoological Society of London; University of Otago; University of Auckland
  摘要：Hatching failure affects up to 77% of eggs laid by threatened bird species, yet the true prevalence and drivers of egg fertilization failure versus embryo mortality as underlying mechanisms of hatching failure are unknown. Here, using ten years of data comprising 4,371 eggs laid by a population of a threatened bird, the hihi (Notiomystis cincta), we investigate the relative importance of infertility and embryo death as drivers of hatching failure and explore population- level factors associate...
• A circuit motif for color in the human foveal retina AI翻译
  作者：Kim, Yeon Jin; Packer, Orin; Dacey, Dennis M.
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：The neural pathways that start human color vision begin in the complex synaptic network of the foveal retina where signals originating in long (L), middle (M), and short (S) wavelength- sensitive cone photoreceptor types are compared through antagonistic interactions, referred to as opponency. In nonhuman primates, two cone opponent pathways are well established: an L vs. M cone circuit linked to the midget ganglion cell type, often called the red- green pathway, and an S vs. L + M cone circui...
• Climate, demography, immunology, and virology combine to drive two decades of dengue virus dynamics in Cambodia AI翻译
  作者：Brook, Cara E.; Rozins, Carly; Bohl, Jennifer A.; Ahyong, Vida; Chea, Sophana; Fahsbender, Liz; Huy, Rekol; Lay, Sreyngim; Leang, Rithea; Li, Yimei; Lon, Chanthap; Man, Somnang; Oum, Mengheng; Northrup, Graham R.; Oliveira, Fabiano; Pacheco, Andrea R.; Parker, Daniel M.; Young, Katherine; Boots, Michael; Tato, Cristina M.; Derisi, Joseph L.; Yek, Christina; Manning, Jessica E.
  作者单位：University of Chicago; York University - Canada; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Chan Zuckerberg Initiative (CZI); Chan Zuckerberg Initiative (CZI); National Center Parasitology, Entomology & Malaria Control; University of California System; University of California Berkeley; University of California System; University of California Irvine; University of California System; University of California Irvine; University of Texas System; University of Texas El Paso; University of California System; University of California Berkeley
  摘要：The incidence of dengue virus disease has increased globally across the past half- century, with highest number of cases ever reported in 2019 and again in 2023. We analyzed climatological, epidemiological, and phylogenomic data to investigate drivers of two decades of dengue in Cambodia, an understudied endemic setting. Using epidemiological models fit to a 19- y dataset, we first demonstrate that climate- driven transmission alone is insufficient to explain three epidemics across the time se...
• Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases AI翻译
  作者：Kueck, Anja F.; van den Boom, Johannes; Koska, Sandra; Ron, David; Meyer, Hemmo
  作者单位：University of Duisburg Essen; University of Cambridge
  摘要：Protein phosphatase-1 catalytic subunit (PP1) joins diverse targeting subunits to form holophosphatases that regulate many cellular processes. Newly synthesized PP1 is known to be transiently sequestered in an inhibitory complex with Suppressor- of-Dis2- number- 2 (SDS22) and Inhibitor- 3 (I3), which is disassembled by the ATPases Associated with diverse cellular Activities plus (AAA+) protein p97. Here, we show that the SDS22- PP1-I3 complex also acts as a thermodynamic sink for mature PP1 an...
• An integrated transcription factor framework for Treg identity and diversity AI翻译
  作者：Chowdhary, Kaitavjeet; Leon, Juliette; Mathis, Diane; Benoist, Christophe
  作者单位：Harvard University; Harvard Medical School; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Vertebrate cell identity depends on the combined activity of scores of transcription factors (TF). While TFs have often been studied in isolation, a systematic perspective on their integration has been missing. Focusing on FoxP3+ regulatory T cells (Tregs), key guardians of immune tolerance, we combined single- cell chromatin accessibility, machine learning, and high- density genetic variation, to resolve a validated framework of diverse Treg chromatin programs, each shaped by multi-TF inputs....
• Type I interferon signaling pathway enhances immune- checkpoint inhibition in KRAS mutant lung tumors AI翻译
  作者：Fernandez-Garcia, Fernando; Fernandez-Rodriguez, Ana; Fustero-Torre, Coral; Pineiro-Yanez, Elena; Wang, Haiyun; Lechuga, Carmen G.; Callejas, Sergio; Alvarez, Rebeca; Lopez-Garcia, Alejandra; Esteban-Burgos, Laura; Salmon, Marina; San Roman, Marta; Guerra, Carmen; Ambrogio, Chiara; Drosten, Matthias; Santamaria, David; Al Shahrour, Fatima; Dopazo, Ana; Barbacid, Mariano; Musteanu, Monica
  作者单位：Tongji University; Centro Nacional de Investigaciones Cardiovasculares (CNIC); Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; University of Turin; Consejo Superior de Investigaciones Cientificas (CSIC); University of Salamanca; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV; Complutense University of Madrid; Helmholtz Association; Max Delbruck Center for Molecular Medicine
  摘要：Lung cancer is the leading cause of cancer mortality worldwide. KRAS oncogenes are responsible for at least a quarter of lung adenocarcinomas, the main subtype of lung cancer. After four decades of intense research, selective inhibitors of KRAS oncoproteins are finally reaching the clinic. Yet, their effect on overall survival is limited due to the rapid appearance of drug resistance, a likely consequence of the high intratumoral heterogeneity characteristic of these tumors. In this study, we ...
• Lactobacillus Firm-5-derived succinate prevents honeybees from having diabetes- like symptoms AI翻译
  作者：Han, Benfeng; Hu, Jiawei; Yang, Chengfeng; Tang, Junbo; Du, Yating; Guo, Lizhen; Wu, Yashuai; Zhang, Xue; Zhou, Xin
  作者单位：China Agricultural University; China Agricultural University; China Agricultural University; China Agricultural University
  摘要：The gut microbiome plays an important role in honeybee hormonal regulation and growth, but the underlying mechanisms are poorly understood. Here, we showed that the depletion of gut bacteria resulted in reduced expression of insulin- like peptide gene (ilp) in the head, accompanied by metabolic syndromes resembling those of Type 1 diabetes in humans: hyperglycemia, impaired lipid storage, and decreased metabolism. These symptoms were alleviated by gut bacterial inoculation. Gut metabolite prof...
• Command of three- dimensional solitary waves via photopatterning AI翻译
  作者：Li, Chao-Yi; Tang, Xing- Zhou; Yu, Xiao; Atzin, Noe; Song, Zhen- Peng; Chen, Chu- Qiao; Abbott, Nicholas L.; Li, Bing- Xiang; de Pablo, Juan J.; Lu, Yan-Qing
  作者单位：Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Nanjing University; Nanjing University of Posts & Telecommunications; Nanjing University of Posts & Telecommunications; University of Chicago; Cornell University; United States Department of Energy (DOE); Argonne National Laboratory
  摘要：Multidimensional solitons are prevalent in numerous research fields. In orientationally ordered soft matter system, three- dimensional director solitons exemplify the localized distortion of molecular orientation. However, their precise manipulation remains challenging due to unpredictable and uncontrolled generation. Here, we utilize preimposed programmable photopatterning in nematics to control the kinetics of director solitons. This enables both unidirectional and bidirectional generation a...
• Prevotella are major contributors of sialidases in the human vaginal microbiome AI翻译
  作者：Pelayo, Paula; Hussain, Fatima A.; Werlang, Caroline A.; Wu, Chloe M.; Woolston, Benjamin M.; Xiang, Claire M.; Rutt, Lindsay; France, Michael T.; Ravel, Jacques; Ribbeck, Katharina; Kwon, Douglas S.; Balskus, Emily P.
  作者单位：Harvard University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Ragon Institute; Massachusetts Institute of Technology (MIT); Northeastern University; University System of Maryland; University of Maryland Baltimore; Harvard University; Howard Hughes Medical Institute
  摘要：Elevated bacterial sialidase activity in the female genital tract is strongly associated with poor health outcomes including preterm birth and bacterial vaginosis (BV). These negative effects may arise from sialidase- mediated degradation of the protective mucus layer in the cervicovaginal environment. Prior biochemical studies of vaginal bacterial sialidases have focused solely on the BV- associated organism Gardnerella vaginalis. Despite their implications for sexual and reproductive health,...