36期

最新文章

• Large-scale genome sequencing of giant pandas improves the understanding of population structure and future conservation initiatives AI翻译
  作者：Lan, Tianming; Yang, Shangchen; Li, Haimeng; Zhang, Yi; Li, Rengui; Sahu, Sunil Kumar; Deng, Wenwen; Liu, Boyang; Shi, Minhui; Wang, Shiqing; Du, Hanyu; Huang, Xiaoyu; Lu, Haorong; Liu, Shanlin; Deng, Tao; Chen, Jin; Wang, Qing; Han, Lei; Zhou, Yajie; Li, Qiye; Li, Desheng; Kristiansen, Karsten; Wan, Qiu - Hong; Liu, Huan; Fang, Sheng - Guo
  作者单位：Zhejiang University; Northeast Forestry University - China; Beijing Genomics Institute (BGI); Northeast Forestry University - China; Beijing Genomics Institute (BGI); Beijing Genomics Institute (BGI); Chinese Academy of Sciences; Institute of Zoology, CAS; University of Copenhagen; Beijing Genomics Institute (BGI)
  摘要：The extinction risk of the giant panda has been demoted from endangered to vulnerable on the International Union for Conservation of Nature Red List, but its habitat is more fragmented than ever before, resulting in 33 isolated giant panda populations according to the fourth national survey released by the Chinese government. Further comprehensive investigations of the genetic background and in- depth assessments of the conservation status of wild populations are still necessary and urgently n...
• Selective optogenetic inhibition of Gαq or Gαi signaling by minimal RGS domains disrupts circuit functionality and circuit formation AI翻译
  作者：Lockyer, Jayde L.; Reading, Andrew; Vicenzi, Silvia; Zbela, Agnieszka; Viswanathan, Saranya; Delandre, Caroline; Newland, Jake W.; McMullen, John P. D.; Marshall, Owen J.; Gasperini, Robert; Foa, Lisa; Lin, John Y.
  作者单位：University of Tasmania; University of Tasmania; Menzies Institute for Medical Research; University of Tasmania; University of California System; University of California San Diego
  摘要：Optogenetic techniques provide genetically targeted, spatially and temporally precise approaches to correlate cellular activities and physiological outcomes. In the nervous system, G protein- coupled receptors (GPCRs) have essential neuromodulatory functions through binding extracellular ligands to induce intracellular signaling cascades. In this work, we develop and validate an optogenetic tool that disrupts G alpha q signaling through membrane recruitment of a minimal regulator of G protein ...
• Using exploratory modeling to challenge narratives of risk governance in Mexico City AI翻译
  作者：Eakin, Hallie; Bojorquez-Tapia, Luis A.; Miquelajauregui, Yosune; Grave, Ileana; Aguilar, Bertha Hernandez; Janssen, Marco A.
  作者单位：Arizona State University; Arizona State University-Tempe; Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico
  摘要：Achieving more sustainable adaptation to social-environmental change demands the transformation of the narratives that provide the rationale for risk governance. These narratives often reflect long- standing beliefs about social and political relationships, ascribe actions and responsibilities, and specify solutions to risk. When such solutions are implemented through material investments in landscapes, these narratives become embedded in physical infrastructure with long legacies. Dominant na...
• Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin (vol 105, pg 3945, 2008) AI翻译
  作者：Garzon, Ramiro; Croce, Carlo M.
• Therapeutic delivery of CCL2 modulates immune response and restores host-microbe homeostasis AI翻译
  作者：Shehabeldin, Mostafa; Gao, Jin; Cho, Yejin; Chong, Rong; Tabib, Tracy; Li, Lu; Smardz, Matthew; Gaffen, Sarah L.; Diaz, Patricia I.; Lafyatis, Robert; Little, Steven R.; Sfeir, Charles
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; State University of New York (SUNY) System; University at Buffalo, SUNY; SUNY Delhi; State University of New York (SUNY) System; University at Buffalo, SUNY; SUNY Delhi; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Many chronic inflammatory diseases are attributed to disturbances in host-microbe interactions, which drive immune- mediated tissue damage. Depending on the anatomic setting, a chronic inflammatory disease can exert unique local and systemic influences, which provide an exceptional opportunity for understanding disease mechanism and testing therapeutic interventions. The oral cavity is an easily accessible environment that allows for protective interventions aiming at modulating the immune res...
• A quantitative model of temperature- dependent diapause progression AI翻译
  作者：von Schmalensee, Loke; Suess, Philip; Roberts, Kevin T.; Gotthard, Karl; Lehmann, Philipp
  作者单位：Stockholm University; Stockholm University; Universitat Greifswald
  摘要：Winter diapause in insects is commonly terminated through cold exposure, which, like vernalization in plants, prevents development before spring arrives. Currently, quantitative understanding of the temperature dependence of diapause termination is limited, likely because diapause phenotypes are generally cryptic to human eyes. We introduce a methodology to tackle this challenge. By consecutively moving butterfly pupae of the species Pieris napi from several different cold conditions to 20 deg...
• Shazam for birds AI翻译
  作者：Freeman, Benjamin G.
  作者单位：University System of Georgia; Georgia Institute of Technology
• Transport coefficient approach for characterizing nonequilibrium dynamics in soft matter (vol 30, e2401162121, 2024) AI翻译
  作者：He, HongRui; Liang, Heyi; Chu, Miaoqi; Jiang, Zhang; de Pablo, Juan J.; Tirrell, Matthew V.; Narayanan, Suresh; Chen, Wei
• Parallel ecological and evolutionary responses to selection in a natural bacterial community AI翻译
  作者：Hesse, Elze; Lujan, Adela M.; O'Brien, Siobhan; Newbury, Arthur; McAvoy, Terence; Pascual, Jesica Soria; Bayer, Florian; Hodgson, David J.; Buckling, Angus
  作者单位：University of Exeter; University of Exeter; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Catholic University of Cordoba; Catholic University of Cordoba; Trinity College Dublin
  摘要：Evolution can occur over ecological timescales, suggesting a potentially important role for rapid evolution in shaping community trait distributions. However, evidence of concordant eco- evolutionary dynamics often comes from in vitro studies of highly simplified communities, and measures of ecological and evolutionary dynamics are rarely directly comparable. Here, we quantified how ecological species sorting and rapid evolution simultaneously shape community trait distributions by tracking wi...
• Lysis of human erythrocytes due to Piezo1-dependent cytosolic calcium overload as a mechanism of circulatory removal AI翻译
  作者：Kuck, Lennart; McNamee, Antony P.; Bordukova, Maria; Sadafi, Ario; Marr, Carsten; Peart, Jason N.; Simmonds, Michael J.
  作者单位：Griffith University; Griffith University - Gold Coast Campus; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Griffith University; Griffith University - Gold Coast Campus
  摘要：Hematopoietic stem cells surrender organelles during differentiation, leaving mature red blood cells (RBC) devoid of transcriptional machinery and mitochondria. The resultant absence of cellular repair capacity limits RBC circulatory longevity, and old cells are removed from circulation. The specific age- dependent alterations required for this apparently targeted removal of RBC, however, remain elusive. Here, we assessed the function of Piezo1, a stretch- activated transmembrane cation channe...