36期

最新文章

• Synonymous codon substitutions modulate transcription and translation of a divergent upstream gene by modulating antisense RNA production AI翻译
  作者：Rodriguez, Anabel; Diehl, Jacob D.; Wright, Gabriel S.; Bonar, Christopher D.; Lundgren, Taylor J.; Moss, McKenze J.; Li, Jun; Milenkovic, Tijana; Huber, Paul W.; Champion, Matthew M.; Emrich, Scott J.; Clark, Patricia L.
  作者单位：Milwaukee School Engineering
  摘要：Synonymous codons were originally viewed as interchangeable, with no phenotypic consequences. However, substantial evidence has now demonstrated that synonymous substitutions can perturb a variety of gene expression and protein homeostasis mechanisms, including translational efficiency, translational fidelity, and cotranslational folding of the encoded protein. To date, most studies of synonymous codon-derived perturbations have focused on effects within a single gene. Here, we show that synon...
• Orientation- independent- DIC imaging reveals that a transient rise in depletion attraction contributes to mitotic chromosome condensation AI翻译
  作者：Iida, Shiori; Ide, Satoru; Tamura, Sachiko; Sasai, Masaki; Tani, Tomomi; Goto, Tatsuhiko; Shribak, Michael; Maeshima, Kazuhiro
  作者单位：Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Graduate University for Advanced Studies - Japan; Kyoto University; Nagoya University; National Institute of Advanced Industrial Science & Technology (AIST); Obihiro University of Agriculture & Veterinary Medicine; Obihiro University of Agriculture & Veterinary Medicine; Marine Biological Laboratory - Woods Hole
  摘要：Genomic information must be faithfully transmitted into two daughter cells during mitosis. To ensure the transmission process, interphase chromatin is further condensed into mitotic chromosomes. Although protein factors like condensins and topoisomerase II alpha are involved in the assembly of mitotic chromosomes, the physical bases of the condensation process remain unclear. Depletion attraction/macromolecular crowding, an effective attractive force that arises between large structures in cro...
• Nucleated synthetic cells with genetically driven intercompartment communication AI翻译
  作者：Ioannou, Ion A.; Monck, Carolina; Ceroni, Francesca; Brooks, Nicholas J.; Kuimova, Marina K.; Elani, Yuval
  作者单位：Imperial College London; Imperial College London; Imperial College London; Imperial College London
  摘要：Eukaryotic cells are characterized by multiple chemically distinct compartments, one of the most notable being the nucleus. Within these compartments, there is a continuous exchange of information, chemicals, and signaling molecules, essential for coordinating and regulating cellular activities. One of the main goals of bottom-up synthetic biology is to enhance the complexity of synthetic cells by establishing functional compartmentalization. There is a need to mimic autonomous signaling betwe...
• Competing gauge fields and entropically driven spin liquid to spin liquid transition in non-Kramers pyrochlores AI翻译
  作者：Lozano-Gomez, Daniel; Noculak, Vincent; Oitmaa, Jaan; Singh, Rajiv R. P.; Iqbal, Yasir; Reuther, Johannes; Gingras, Michel J. P.
  作者单位：University of Waterloo; Technische Universitat Dresden; Technische Universitat Dresden; Free University of Berlin; Free University of Berlin; Helmholtz Association; Helmholtz-Zentrum fuer Materialien und Energie GmbH (HZB); University of New South Wales Sydney; University of California System; University of California Davis; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras
  摘要：Gauge theories are powerful theoretical physics tools that allow complex phenomena to be reduced to simple principles and are used in both high-energy and condensed matter physics. In the latter context, gauge theories are becoming increasingly popular for capturing the intricate spin correlations in spin liquids, exotic states of matter in which the dynamics of quantum spins never ceases, even at absolute zero temperature. We consider a spin system on a three-dimensional pyrochlore lattice wh...
• Multifunctional biomolecular corona- inspired nanoremediation of antibiotic residues AI翻译
  作者：Hou, Jie; Lu, Yuqi; Chen, Qiqi; Liao, Xinyi; Wu, Xinyue; Sang, Kaijian; White, Jason C.; Gardea-Torresdey, Jorge L.; Xu, Jiang; Zhang, Jianying; Yang, Kun; Zhu, Lizhong; Lin, Daohui
  作者单位：Zhejiang University; Zhejiang University; Connecticut Agricultural Experiment Station; University of Texas System; University of Texas El Paso; Zhejiang University
  摘要：Facing complex and variable emerging antibiotic pollutants, the traditional development of functional materials is a trial- and- error process based on physicochemical principles, where laborious steps and long timescales make it difficult to accelerate technical breakthroughs. Notably, natural biomolecular coronas derived from highly tolerant organisms under significant contamination scenarios can be used in conjunction with nanotechnology to tackling emerging contaminants of concern. Here, s...
• HIV-1 control in vivo is related to the number but not the fraction of infected cells with viral unspliced RNA AI翻译
  作者：Capoferri, Adam A.; Wiegand, Ann; Hong, Feiyu; Jacobs, Jana L.; Spindler, Jonathan; Musick, Andrew; Bale, Michael J.; Shao, Wei; Sobolewski, Michele D.; Cillo, Anthony R.; Luke, Brian T.; Fennessey, Christine M.; Gorelick, Robert J.; Hoh, Rebecca; Halvas, Elias K.; Deeks, Steven G.; Coffin, John M.; Mellors, John W.; Kearney, Mary F.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Georgetown University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; Cornell University; Weill Cornell Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of California System; University of California San Francisco; Tufts University
  摘要：In the absence of antiretroviral therapy (ART), a subset of individuals, termed HIV controllers, have levels of plasma viremia that are orders of magnitude lower than non- controllers (NC) who are at higher risk for HIV disease progression. In addition to having fewer infected cells resulting in fewer cells with HIV RNA, it is possible that lower levels of plasma viremia in controllers are due to a lower fraction of the infected cells having HIV- 1 unspliced and quantitative single- cell seque...
• Heisenberg spin chain with random-sign couplings AI翻译
  作者：Fava, Michele; Jacobsen, Jesper Lykke; Nahum, Adam
  作者单位：Universite PSL; Ecole Normale Superieure (ENS); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Universite Paris Cite; Universite PSL; Sorbonne Universite; Sorbonne Universite; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS)
  摘要：We study the 1D quantum Heisenberg chain with randomly ferromagnetic or antiferromagnetic couplings [a model previously studied by approximate strong- disorder renormalization group (RG)]. We find that, at least for sufficiently large spin S , the ground state has spin glass order. The spin waves on top of this state have the dynamical exponent z = 3/2, intermediate between the values z = 1 of the antiferromagnet and z = 2 of the ferromagnet. Density matrix renormalization group (DMRG) simulat...
• The limits of doing global, cross- cultural behavioral science research AI翻译
  作者：Gvirtz, Andres; Sabherwal, Anandita
  作者单位：University of London; King's College London; University of London; London School Economics & Political Science
• Postprandial cardiac hypertrophy is sustained by mechanics, epigenetic, and metabolic reprogramming in pythons AI翻译
  作者：Crocini, Claudia; Woulfe, Kathleen C.; Ozeroff, Christopher D.; Perni, Stefano; Cardiello, Joseph; Walker, Cierra J.; Wilson, Cortney E.; Anseth, Kristi; Allen, Mary Ann; Leinwand, Leslie A.
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado System; University of Colorado Anschutz Medical Campus
  摘要：Constricting pythons, known for their ability to consume infrequent, massive meals, exhibit rapid and reversible cardiac hypertrophy following feeding. Our primary goal was to investigate how python hearts achieve this adaptive response after feeding. Isolated myofibrils increased force after feeding without changes in sarcomere ultrastructure and without increasing energy cost. Ca2+ transients were prolonged after feeding with in decreased cardiac tissue stiffness. Feeding also reduced the ac...
• Unchecked growth: Pushing the limits on RNA virus genome size in the absence of known proofreading AI翻译
  作者：Glasner, Dustin R.; Daugherty, Matthew D.
  作者单位：University of California System; University of California San Diego