36期

最新文章

• Reply to McGowan et al.: An intronic polymorphism associated with 2,3-bisphosphoglycerate levels in human red blood cells is linked to expression of RhCE blood groups AI翻译
  作者：Earley, Eric J.; D'Alessandro, Angelo; Kaestner, Lars; Page, Grier P.
  作者单位：Research Triangle Institute; University of Colorado System; University of Colorado Anschutz Medical Campus; Children's Hospital Colorado; Universitatsklinikum des Saarlandes; Saarland University; Research Triangle Institute
• Microglial cGAS-STING signaling underlies glaucoma pathogenesis AI翻译
  作者：Liu, Yutong; Wang, Ailian; Chen, Chen; Zhang, Qian; Shen, Qin; Zhang, Dan; Xiao, Xueqi; Chen, Shasha; Lian, Lili; Le, Zhenmin; Liu, Shengduo; Liang, Tingbo; Zheng, Qinxiang; Xu, Pinglong; Zou, Jian
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Wenzhou University; Wenzhou Medical University
  摘要：Characterized by progressive degeneration of retinal ganglion cells (RGCs) and vision loss, glaucoma is the primary cause of irreversible blindness, incurable and affecting over 78 million patients. However, pathogenic mechanisms leading to glaucoma- induced RGC loss are incompletely understood. Unexpectedly, we found that cGAS-STING (2 ' 3 '- cyclic GMP- AMP-stimulator of interferon genes) signaling, which surveils displaced double- stranded DNA (dsDNA) in the cytosol and initiates innate imm...
• Supporting Information for Chen et al., Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration (vol 116, pg 5765, 2019) AI翻译
  作者：Chen, Xi; Kordich, Jennifer K.; Williams, Erin T.; Levine, Nathan; Cole-Strauss, Allyson; Marshall, Lee; Labrie, Viviane; Ma, Jiyan; Lipton, Jack W.; Moore, Darren J.
• Breaking (musical) boundaries by investigating brain dynamics of event segmentation during real- life music- listening AI翻译
  作者：Burunat, Iballa; Levitin, Daniel J.; Toiviainen, Petri
  作者单位：University of Jyvaskyla; McGill University
  摘要：The perception of musical phrase boundaries is a critical aspect of human musical experience: It allows us to organize, understand, derive pleasure from, and remember music. Identifying boundaries is a prerequisite for segmenting music into meaningful chunks, facilitating efficient processing and storage while providing an enjoyable, fulfilling listening experience through the anticipation of upcoming musical events. Expanding on Sridharan et al.'s [Neuron 55, 521-532 (2007)] work on coarse mu...
• Imprinted X chromosome inactivation in marsupials: The paternal X arrives at the egg with a silent DNA methylation profile AI翻译
  作者：Milton, Ashley M.; Marin-Gual, Laia; Lister, Nicholas C.; McIntyre, Kim L.; Grady, Patrick G. S.; Laird, Melanie K.; Bond, Donna M.; Hore, Timothy A.; O'Neill, Rachel J.; Pask, Andrew J.; Renfree, Marilyn B.; Ruiz-Herrera, Aurora; Waters, Paul D.
  作者单位：University of New South Wales Sydney; Autonomous University of Barcelona; Autonomous University of Barcelona; University of Connecticut; University of Connecticut; University of Otago; University of Melbourne
  摘要：X chromosome inactivation (XCI) is an epigenetic process that results in the transcriptional silencing of one X chromosome in the somatic cells of females. This phenomenon is common to both eutherian and marsupial mammals, but there are fundamental differences. In eutherians, the X chosen for silencing is random. DNA methylation on the eutherian inactive X is high at transcription start sites (TSSs) and their flanking regions, resulting in universally high DNA methylation. This contrasts XCI i...
• Non- CG DNA hypomethylation promotes photosynthesis and nitrogen fixation in soybean AI翻译
  作者：Xun, Hongwei; Wang, Yadi; Yuan, Jing; Lian, Lijie; Feng, Wanjie; Liu, Shuhan; Hong, Jianhui; Liu, Bao; Ma, Jianxin; Wang, Xutong
  作者单位：Northeast Normal University - China; Huazhong Agricultural University; Huazhong Agricultural University; Purdue University System; Purdue University; Purdue University System; Purdue University
  摘要：Non- CG DNA methylation, a plant- specific epigenetic mark mainly regulated by chromomethylase (CMT), is known to play important roles in Arabidopsis thaliana. However, whether and to what extent non- CG DNA methylation modulates agronomic traits in crops remain to be explored. Here, we describe the consequences of non- CG DNA hypomethylation on development, seed composition, and yield in soybean ( Glycine max ). We created a Gmcmt mutant line lacking function of all four CMT genes. This line ...
• David Penny-An indomitable evolutionary biologist AI翻译
  作者：Charleston, Michael A.
  作者单位：University of Tasmania
• Language models align with human judgments on key grammatical constructions AI翻译
  作者：Hu, Jennifer; Mahowald, Kyle; Lupyan, Gary; Ivanova, Anna; Levy, Roger
  作者单位：Harvard University; University of Texas System; University of Texas Austin; University of Wisconsin System; University of Wisconsin Madison; University System of Georgia; Georgia Institute of Technology; Massachusetts Institute of Technology (MIT)
• A neural network for religious fundamentalism derived from patients with brain lesions AI翻译
  作者：Ferguson, Michael A.; Asp, Erik W.; Kletenik, Isaiah; Tranel, Daniel; Boes, Aaron D.; Nelson, Jenae M.; Schaper, Frederic L. W. V. J.; Siddiqi, Shan; Turner, Joseph I.; Anderson, J. Seth; Nielsen, Jared A.; Bateman, James R.; Grafman, Jordan; Fox, Michael D.
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; University of Iowa; Mitchell Hamline School of Law; Mitchell Hamline School of Law; University of Iowa; University of Iowa; University of Iowa; Baylor University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Boston University; Brigham Young University; Wake Forest University; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Shirley Ryan AbilityLab
  摘要：Religious fundamentalism, characterized by rigid adherence to a set of beliefs putatively revealing inerrant truths, is ubiquitous across cultures and has a global impact on society. Understanding the psychological and neurobiological processes producing religious fundamentalism may inform a variety of scientific, sociological, and cultural questions. Research indicates that brain damage can alter religious fundamentalism. However, the precise brain regions involved with these changes remain u...
• Functional near- infrared spectroscopy: A novel tool for detecting consciousness after acute severe brain injury AI翻译
  作者：Kazazian, Karnig; Abdalmalak, Androu; Novi, Sergio L.; Norton, Loretta; Ardakani, Reza Moulavi -; Kolisnyk, Matthew; Gofton, Teneille E.; Mesquita, Rickson C.; Owen, Adrian M.; Debicki, Derek B.
  作者单位：Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario); University of Birmingham; Universidade Estadual de Campinas; Western University (University of Western Ontario)
  摘要：Recent advancements in functional neuroimaging have demonstrated that some unresponsive patients in the intensive care unit retain a level of consciousness that is inconsistent with their behavioral diagnosis of awareness. Functional near- infrared spectroscopy (fNIRS) is a portable optical neuroimaging method that can be used to measure neural activity with good temporal and spatial resolution. However, the reliability of fNIRS for detecting the neural correlates of consciousness remains to b...