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作者：Rains, Stephen A.; Richards, Adam S.
作者单位：University of Arizona
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作者：Wang, Beijia; Najmudin, Shabir; Pan, Xiao-Su; Mykhaylyk, Vitaliy; Orr, Christian; Wagner, Armin; Govada, Lata; Chayen, Naomi E.; Fisher, L. Mark; Sanderson, Mark R.
作者单位：Imperial College London; City St Georges, University of London; Diamond Light Source
摘要：Metal ions have important roles in supporting the catalytic activity of DNA-regulating enzymes such as topoisomerases (topos). Bacterial type II topos, gyrases and topo IV, are primary drug targets for fluoroquinolones, a class of clinically relevant antibacterials requiring metal ions for efficient drug binding. While the presence of metal ions in topos has been elucidated in biochemical studies, accurate location and assignment of metal ions in structural studies have historically posed sign...
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作者：Williams, Sarah C. P.
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作者：Gates, Alexander J.; Ke, Qing; Barabasi, Albert-Laszlo
作者单位：University of Virginia; City University of Hong Kong; Northeastern University; Central European University; Harvard University; Harvard Medical School
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作者：Biester, Alison; Grahame, David A.; Drennan, Catherine L.
作者单位：Massachusetts Institute of Technology (MIT); Uniformed Services University of the Health Sciences - USA; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute
摘要：Approximately two- thirds of the estimated one- billion metric tons of methane produced annually by methanogens is derived from the cleavage of acetate. Acetate is broken down by a Ni- Fe- S- containing A- cluster within the enzyme acetyl-CoA synthase (ACS) to carbon monoxide (CO) and a methyl group (CH3+). The methyl group ultimately forms the greenhouse gas methane, whereas CO is converted to the greenhouse gas carbon dioxide (CO2) by a Ni- Fe- S- containing C- cluster within the enzyme carb...
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作者：Kim, Byeong- Hoon; Seo, Ki- Weon; Lee, Choon-Ki; Kim, Jae- Seung; Lee, Won Sang; Jin, Emilia Kyung; van den Broeke, Michiel
作者单位：Korea Polar Research Institute (KOPRI); Seoul National University (SNU); Utrecht University
摘要：We investigate the mass changes of Antarctic glaciers from 2003 to 2020, partitioning them into the contributions of surface mass balance (SMB) and ice discharge, using high- resolution ice mass change estimates derived from the combination of two different types of satellite observations (gravimetry and altimetry) and outputs from a regional climate model. Our analysis indicates that changes in ice discharge have played a dominant role in ongoing ice mass trends and their accelerations, espec...
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作者：Pathak, Varun; Bertelli, Pietro M.; Pedrini, Edoardo; Harkin, Kevin; Peixoto, Elisa; Allen, Lynsey - Dawn; Mcloughlin, Kiran; Chavda, Natasha D.; Hamill, Kevin J.; Fuchs, Jasenka Guduric -; Inforzato, Antonio; Bottazzi, Barbara; Stitt, Alan W.; Medina, Reinhold J.
作者单位：Queens University Belfast; Humanitas University
摘要：Diabetic retinopathy (DR) is a common complication of diabetes characterized by vascular pathology and neuroinflammation. Pentraxin 3 (PTX3) is a soluble pattern recognition molecule that functions at the crossroads between innate immunity, inflammation, and tissue remodeling. DR is known to involve inflammatory pathways, although the potential relevance of PTX3 has not been explored. We found that PTX3 protein levels increased in the retina of diabetic mice. Similarly, evaluation of a publicl...
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作者：Zheng, Jeana Aojie; Holmes-Cerfon, Miranda; Pine, David J.; Marbach, Sophie
作者单位：New York University; University of British Columbia; New York University; New York University; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite
摘要：Understanding the motion of particles with multivalent ligand-receptors is important for biomedical applications and material design. Yet, even among a single design, the prototypical DNA-coated colloids, seemingly similar micrometric particles hop or roll, depending on the study. We shed light on this problem by observing DNA-coated colloids diffusing near surfaces coated with complementary strands for a wide array of coating designs. We find colloids rapidly switch between 2 modes: They hop-...
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作者：Fandino, Richard A.; Brady, Noah K.; Chatterjee, Martik; Mcdonald, Jeanne M. C.; Livraghi, Luca; van der Burg, Karin R. L.; Mazo-Vargas, Anyi; Markenscoff-Papadimitriou, Eirene; Reed, Robert D.
作者单位：Cornell University; George Washington University; Clemson University; Cornell University
摘要：Long noncoding RNAs (lncRNAs) are transcribed elements increasingly recognized for their roles in regulating gene expression. Thus far, however, we have little understanding of how lncRNAs contribute to evolution and adaptation. Here, we show that a conserved lncRNA, ivory, is an important color patterning gene in the buckeye butterfly Junonia coenia. ivory overlaps with cortex, a locus linked to multiple cases of crypsis and mimicry in Lepidoptera. Along with a companion paper by Livraghi et ...
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作者：Liang, Xing; Zhao, Yuping; Yan, Jun; Zhang, Qian; James, Tony D.; Lin, Weiying
作者单位：Guangxi University; University of Bath; Henan Normal University
摘要：Deciphering the dynamic mechanism of ferroptosis can provide insights into pathogenesis, which is valuable for disease diagnosis and treatment. However, due to the lack of suitable time- resolved mechanosensitive tools, researchers have been unable to determine the membrane tension and morphology of the plasma membrane and the nuclear envelope during ferroptosis. With this research, we propose a rational strategy to develop robust mechanosensitive fluorescence lifetime probes which can facilit...
