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作者：Smart, Matthew; Shvartsman, Stanislav Y.; Gershman, Samuel J.
作者单位：Simons Foundation; Flatiron Institute; Princeton University; Princeton University; Ruhr University Bochum
摘要：Habituation-a phenomenon in which a dynamical system exhibits a diminishing response to repeated stimulations that eventually recovers when the stimulus is withheld-is universally observed in living systems from animals to unicellular organisms. Despite its prevalence, generic mechanisms for this fundamental form of learning remain poorly defined. Drawing inspiration from prior work on systems that respond adaptively to step inputs, we study habituation from a nonlinear dynamics perspective. T...
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作者：Gao, Mu; Skolnick, Jeffrey
作者单位：University System of Georgia; Georgia Institute of Technology
摘要：Identifying antibodies that neutralize specific antigens is crucial for developing effective immunotherapies, but this task remains challenging for many target antigens. The rise of deep learning-based computational approaches presents a promising avenue to address this challenge. Here, we assess the performance of a deep learning approach through two benchmark tests aimed at predicting antibodies for the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-...
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作者：Gadea, Esteban D.; Sirkin, Yamila A. Perez; Molinero, Valeria; Scherlis, Damian A.
作者单位：University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Utah System of Higher Education; University of Utah
摘要：Many of the relevant electrochemical processes in the context of catalysis or energy conversion and storage, entail the production of gases. This often implicates the nucleation of bubbles at the interface, with the concomitant blockage of the electroactive area leading to overpotentials and Ohmic drop. Nanoelectrodes have been envisioned as assets to revert this effect, by inhibiting bubble formation. Experiments show, however, that nanobubbles nucleate and attach to nanoscale electrodes, imp...
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作者：Fan, Lijuan; Liu, Bingnan; Wang, Youxia; Tang, Bin; Xu, Tianqi; Fu, Jian; Wang, Chuanlong; Liu, Yuan; Ge, Liangpeng; Wei, Hong; Ren, Wenkai
作者单位：South China Agricultural University; Chongqing University; Yangzhou University; Chongqing Academy of Animal Sciences; Huazhong Agricultural University; Huazhong Agricultural University
摘要：Gut microbiota plays a vital role in host metabolism; however, the influence of gut microbes on polyamine metabolism is unknown. Here, we found germ- free models possess elevated polyamine levels in the colon. Mechanistically, intestinal Lactobacillus murinus- derived small RNAs in extracellular vesicles down- regulate host polyamine metabolism by targeting the expression of enzymes in polyamine metabolism. In addition, Lactobacillus murinus delays recovery of dextran sodium sulfate- induced c...
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作者：Wang, Yujue; Xu, Youwei; Wang, Yue; Zhang, Jie; Chen, Lan; He, Xinheng; Fan, Wenjia; Wu, Kai; Hu, Wen; Cheng, Xi; Yang, Guizhu; Xu, H. Eric; Zhuang, Youwen; Sun, Shuyang
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Nanjing University of Chinese Medicine; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Shanghai Jiao Tong University
摘要：Somatostatin receptors (SSTRs) exert critical biological functions such as negatively regulating hormone release and cell proliferation, making them popular targets for developing therapeutics to treat endocrine disorders, especially neuroendocrine tumors. Although several panagonists mimicking the endogenous ligand somatostatin are available, the development of more effective and safer somatostatinergic therapies is limited due to a lack of molecular understanding of the ligand recognition an...
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作者：Ma, Qizhao; Li, Jing; Yu, Shuxing; Zhou, Jing; Liu, Yaqi; Wang, Xinyue; Ye, Dingwei; Wu, Yumeng; Gong, Tao; Zhang, Qiong; Wang, Lingyun; Zou, Jing; Li, Yuqing
作者单位：Sichuan University; Sichuan University; Yale University; Sichuan University
摘要：Protein acetylation is a common and reversible posttranslational modification tightly governed by protein acetyltransferases and deacetylases crucial for various biological processes in both eukaryotes and prokaryotes. Although recent studies have characterized many acetyltransferases in diverse bacterial species, only a few protein deacetylases have been identified in prokaryotes, perhaps in part due to their limited sequence homology. In this study, we identified YkuR, encoded by smu_318, as...
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作者：Fitzgerald, Jack
作者单位：Vrije Universiteit Amsterdam
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作者：Bhasin, Brandon J.; Raymond, Jennifer L.; Goldman, Mark S.
作者单位：Stanford University; University of California System; University of California Davis; Stanford University; University of California System; University of California Davis; University of California System; University of California Davis
摘要：Systems consolidation is a common feature of learning and memory systems, in which a long-term memory initially stored in one brain region becomes persistently stored in another region. We studied the dynamics of systems consolidation in simple circuit architectures with two sites of plasticity, one in an early-learning and one in a late-learning brain area. We show that the synaptic dynamics of the circuit during consolidation of an analog memory can be understood as a temporal integration pr...
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作者：Stransky, Laura A.; Gao, Wenhua; Schmidt, Laura S.; Bi, Kevin; Ricketts, Christopher J.; Ramesh, Vijyendra; James, Amy; Difilippantonio, Simone; Ileva, Lilia; Kalen, Joseph D.; Karim, Baktiar; Jeon, Albert; Morgan, Tamara; Warner, Andrew C.; Turan, Sevilay; Unite, Joanne; Tran, Bao; Choudhari, Sulbha; Zhao, Yongmei; Linn, Douglas E.; Yun, Changhong; Dhandapani, Sripriya; Parab, Vaishali; Pinheiro, Elaine M.; Morris, Nicole; He, Lixia; Vigeant, Sean M.; Pignon, Jean- Christophe; Ivins, Maura Sticco --; Signoretti, Sabina; Allen, Eliezer M. Van; Linehan, W. Marston; Kaelin, William G.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; Merck & Company; Merck & Company USA; Merck & Company; Merck & Company USA; Merck & Company; Merck & Company USA; Merck & Company; Merck & Company USA; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Howard Hughes Medical Institute
摘要：CRISPR is revolutionizing the ability to do somatic gene editing in mice for the purpose of creating new cancer models. Inactivation of the VHL tumor suppressor gene is the signature initiating event in the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC). Such tumors are usually driven by the excessive HIF2 activity that arises when the VHL gene product, pVHL, is defective. Given the pressing need for a robust immunocompetent mouse model of human ccRCC, we directly i...
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作者：Schoenbrun, David
作者单位：Northwestern University
