-
作者：Cui, Mengying; Yamano, Koji; Yamamoto, Kenichi; Yamamoto-Imoto, Hitomi; Minami, Satoshi; Yamamoto, Takeshi; Matsui, Sho; Kaminishi, Tatsuya; Shima, Takayuki; Ogura, Monami; Tsuchiya, Megumi; Nishino, Kohei; Layden, Brian T.; Kato, Hisakazu; Matsuda, Noriyuki; Yoshimor, Tamotsu; Nakamura, Shuhei
-
作者：Gavrilchenko, Tatyana; Simpkins, Alison G.; Simpson, Tanner; Barrett, Lena A.; Hansen, Pauline; Shvartsman, Stanislav Y.; Schottenfeld-Roames, Jodi
作者单位：Simons Foundation; Flatiron Institute; Princeton University; Princeton University; McKinsey & Company
摘要：The terminal cells of the Drosophila larval tracheal system are perhaps the simplest delivery networks, providing an analogue for mammalian vascular growth and function in a system with many fewer components. These cells are a prime example of single-cell morphogenesis, branching significantly over time to adapt to the needs of the growing tissue they supply. While the genetic mechanisms governing local branching decisions have been studied extensively, an understanding of the emergence of a g...
-
作者：Safavi, Shervin; Chalk, Matthew; Logothetis, Nikos K.; Levina, Anna
作者单位：Technische Universitat Dresden; Max Planck Society; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Eberhard Karls University of Tubingen
摘要：The critical brain hypothesis states that the brain can benefit from operating close to a second-order phase transition. While it has been shown that several computational aspects of sensory processing (e.g., sensitivity to input) can be optimal in this regime, it is still unclear whether these computational benefits of criticality can be leveraged by neural systems performing behaviorally relevant computations. To address this question, we investigate signatures of criticality in networks opt...
-
作者：Zhou, Wei; Van Sinderen, Michelle; Rainczuk, Katarzyna; Menkhorst, Ellen; Sorby, Kelli; Osianlis, Tiki; Pangestu, Mulyoto; Santos, Leilani; Rombauts, Luk; Diez, Alberto Rosello -; Dimitriadis, Evdokia
作者单位：University of Melbourne; The Royal Women's Hospital; Hudson Institute of Medical Research; Monash University; Monash University; Universitas Jenderal Soedirman; Monash University; Australian Regenerative Medicine Institute; University of Cambridge; University of Cambridge
摘要：The endometrium undergoes substantial remodeling in each menstrual cycle to become receptive to an implanting embryo. Abnormal endometrial receptivity is one of the major causes of embryo implantation failure and infertility. MicroRNA- 124- 3p is elevated in both the serum and endometrial tissue of women with chronic endometritis, a condition associated with infertility. MicroRNA- 124- 3p also has a role in cell adhesion, a key function during receptivity to allow blastocysts to adhere and imp...
-
作者：Bhattacharyya, Souvik; Lopez, Shelby; Singh, Abhyudai; Harshey, Rasika M.
作者单位：University of Texas System; University of Texas Austin; University of Delaware
摘要：Flagella are highly complex rotary molecular machines that enable bacteria to not only migrate to optimal environments but also to promote range expansion, competitiveness, virulence, and antibiotic survival. Flagellar motility is an energy-demanding process, where the sum of its production (biosynthesis) and operation (rotation) costs has been estimated to total similar to 10% of the entire energy budget of an Escherichia coli cell. The acquisition of such a costly adaptation process is expec...
-
作者：Krishnamoorthi, Arjun; Salom, David; Wu, Arum; Palczewski, Krzysztof; Rentzepis, Peter M.
作者单位：Texas A&M University System; Texas A&M University College Station; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine
摘要：The ultrafast photochemical reaction mechanism, transient spectra, and transition kinetics of the human blue cone visual pigment have been recorded at room temperature. Ultrafast time-resolved absorption spectroscopy revealed the progressive formation and decay of several metastable photo-intermediates, corresponding to the Batho to Meta-II photo-intermediates previously observed with bovine rhodopsin and human green cone opsin, on the picosecond to millisecond timescales following pulsed exci...
-
作者：Simony, Erez; Grossman, Shany; Malach, Rafael
作者单位：Weizmann Institute of Science; Max Planck Society; Max Planck Society; University of Hamburg
摘要：Central nervous system neurons manifest a rich diversity of selectivity profiles-whose precise role is still poorly understood. Following the striking success of artificial networks, a major debate has emerged concerning their usefulness in explaining neuronal properties. Here we propose that finding parallels between artificial and neuronal networks is informative precisely because these systems are so different from each other. Our argument is based on an extension of the concept of converge...
-
作者：Oluwole, Abraham O.; Kalmankar, Neha V.; Guida, Michela; Bennett, Jack L.; Poce, Giovanna; Bolla, Jani R.; Robinson, Carol V.
作者单位：University of Oxford; University of Oxford; Sapienza University Rome; University of Oxford
摘要：The peptidoglycan pathway represents one of the most successful antibacterial targets with the last critical step being the flipping of carrier lipid, undecaprenyl phosphate (C-55-P), across the membrane to reenter the pathway. This translocation of C-55-P is facilitated by DedA and DUF368 domain-containing family membrane proteins via unknown mechanisms. Here, we employ native mass spectrometry to investigate the interactions of UptA, a member of the DedA family of membrane protein from Bacil...
-
作者：Yu, Yulin; Romero, Daniel M.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要：Scientific datasets play a crucial role in contemporary data-driven research, as they allow for the progress of science by facilitating the discovery of new patterns and phenomena. This mounting demand for empirical research raises important questions on how strategic data utilization in research projects can stimulate scientific advancement. In this study, we examine the hypothesis inspired by the recombination theory, which suggests that innovative combinations of existing knowledge, includi...
-
作者：Bratsberg, Bernt; Fjell, Anders M.; Rogeberg, Ole J.; Skirbekk, Vegard F.; Walhovd, Kristine B.
作者单位：Norwegian Institute of Public Health (NIPH); University of Oslo; University of Oslo; Columbia University
摘要：Major initiatives attempt to prevent dementia by targeting modifiable risk factors. Low education is frequently pointed to, due to its relationship with dementia. Impact of education is difficult to assess, however, because of associations with multiple other factors, requiring large population-representative samples to tease the relationships apart. We studied 207,814 Norwegian men born between 1950 and 1959 who underwent compulsory cognitive testing during military conscription as young adul...
