41期

最新文章

• Evidence for a survival-driven traveling wave in a keystone boreal predator population AI翻译
  作者：Arnold, Derek A.; Breed, Greg A.; Laufenberg, Jared S.; Berg, Nathan D.; Bertram, Mark R.; Scotton, Bradley D.; Kielland, Knut
  作者单位：University of Alaska System; University of Alaska Fairbanks; University of Alaska System; University of Alaska Fairbanks; United States Department of the Interior; US Fish & Wildlife Service; United States Department of the Interior; US Fish & Wildlife Service; United States Department of the Interior; US Fish & Wildlife Service; United States Department of the Interior; US Fish & Wildlife Service
  摘要：Cyclical population dynamics are a common phenomenon in populations worldwide, yet the spatial organization of these cycles remains poorly understood. In this study, we investigated the spatial form and timing of a population collapse from 2018 to 2022 in Canada lynx ( Lynx canadensis) across the northwest boreal forest. We analyzed survival, reproduction, and dispersal data from 143 individual global positioning system (GPS) collared lynx from populations across five study sites spanning inte...
• Make it or break it: Protein homeostasis in the synaptonemal complex AI翻译
  作者：Kursel, Lisa E.; Rog, Ofer
  作者单位：Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah
• Toward defining the Anthropocene onset using a rapid increase in anthropogenic fingerprints in global geological archives AI翻译
  作者：Kuwae, Michinobu; Yokoyama, Yusuke; Tims, Stephen; Froehlich, Michaela; Fifield, L. Keith; Aze, Takahiro; Tsugeki, Narumi; Doi, Hideyuki; Saito, Yoshiki
  作者单位：Ehime University; University of Tokyo; Australian National University; Matsuyama University; Kyoto University; Shimane University; National Institute of Advanced Industrial Science & Technology (AIST)
  摘要：One of the remaining issues regarding the Anthropocene is the lack of stratigraphic evidence indicating when the cumulative human pressure from the early Holocene began to fundamentally change the Earth system. Herein, we compile anthropogenic fingerprints from various high-precision-dated proxy records for 137 global sites to determine the age of the unprecedented surge in these records over the last 7700 y. The cumulative number of fingerprints revealed an unprecedented surge in diverse anth...
• Increasing benefits in one-time public goods does not promote cooperation AI翻译
  作者：Struwe, Natalie; Blanco, Esther; Walker, James M.
  作者单位：University of Innsbruck; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
  摘要：The long tradition of research on cooperation includes a well-established finding that individuals respond to the degree of conflict between self-and collective interests (that is, the relative benefits from cooperation) in providing public goods. Existing empirical evidence builds upon settings where participants make multiple decisions or strategically consider alternative scenarios. Here, we consider a decision setting where participants face a one-time (single-decision) setting. One-time c...
• Topology, dynamics, and control of a muscle-architected soft arm AI翻译
  作者：Tekinalp, Arman; Naughton, Noel; Kim, Seung Hyun; Halder, Udit; Gillette, Rhanor; Mehta, Prashant G.; Kier, William; Gazzola, Mattia
  作者单位：Virginia Polytechnic Institute & State University; State University System of Florida; University of South Florida; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of North Carolina; University of North Carolina Chapel Hill; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Muscular hydrostats, such as octopus arms or elephant trunks, lack bones entirely, endowing them with exceptional dexterity and reconfigurability. Key to their unmatched ability to control nearly infinite degrees of freedom is the architecture into which muscle fibers are weaved. Their arrangement is, effectively, the instantiation of a sophisticated mechanical program that mediates, and likely facilitates, the control and realization of complex, dynamic morphological reconfigurations. Here, b...
• Enhancer landscape of lung neuroendocrine tumors reveals regulatory and developmental signatures with potential theranostic implications AI翻译
  作者：Davis, Ester; Avniel-Polak, Shani; Abu-Kamel, Shahd; Antman, Israel; Saadoun, Tsipora; Brim, Chava; Jumaa, Mohammad; Maron, Yariv; Maimon, Ofra; Bel-Ange, Anat; Atlan, Karine; Tzur, Tomer; Abu Akar, Firas; Wald, Ori; Izhar, Uzi; Hecht, Merav; Grozinsky-Glasberg, Simona; Drier, Yotam
  作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem; Hadassah University Hospital; Hebrew University of Jerusalem; Hadassah University Hospital; Hebrew University of Jerusalem; Hebrew University of Jerusalem; Hadassah University Hospital; Hebrew University of Jerusalem; Hadassah University Hospital; Tel Aviv University; Al-Quds University; Tel Aviv University
  摘要：Well- differentiated low- grade lung neuroendocrine tumors (lung carcinoids or LNETs) are histopathologically classified as typical and atypical LNETs, but each subtype is still heterogeneous at both the molecular level and its clinical manifestation. Here, we report genome-wide profiles of primary LNETs' cis- regulatory elements by H3K27ac ChIP-seq with matching RNA-seq profiles. Analysis of these regulatory landscapes revealed three regulatory subtypes, independent of the typical/atypical cl...
• Embers of autoregression show how large language models are shaped by the problem they are trained to solve AI翻译
  作者：McCoy, R. Thomas; Yao, Shunyu; Friedman, Dan; Hardy, Mathew D.; Griffiths, Thomas L.
  作者单位：Princeton University; Princeton University; Yale University; Yale University; OpenAI
  摘要：The widespread adoption of large language models (LLMs) makes it important to recognize their strengths and limitations. We argue that to develop a holistic understanding of these systems, we must consider the problem that they were trained to solve: next-word prediction over Internet text. By recognizing the pressures that this task exerts, we can make predictions about the strategies that LLMs will adopt, allowing us to reason about when they will succeed or fail. Using this approach-which w...
• RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse (vol 121, e2320995121, 2024) AI翻译
  作者：Condezo, Yazmine B.; Sainz-Urruela, Raquel; Gomez-H, Laura; Salas-Lloret, Daniel; Felipe-Medina, Natalia; Bradley, Rachel; Wolff, Ian D.; Tanis, Stephanie; Barbero, Jose Luis; Sanchez-Martin, Manuel; de Rooij, Dirk; Hendriks, Ivo A.; Nielsen, Michael L.; Gonzalez-Prieto, Roman; Cohen, Paula E.; Pendas, Alberto M.; Llano, Elena
• Deep learning sharpens vistas on biodiversity mapping AI翻译
  作者：Givnish, Thomas J.
  作者单位：University of Wisconsin System; University of Wisconsin Madison
• A conserved peptide- binding pocket in HyNaC/ASIC ion channels AI翻译
  作者：Ortega-Ramirez, Audrey Magdalena; Albani, Simone; Bachmann, Michele; Schmidt, Axel; Pinoe, Manuela; Assmann, Marc; Augustinowski, Katrin; Rossetti, Giulia; Gruender, Stefan
  作者单位：University of Bonn; University of Bonn; RWTH Aachen University; Helmholtz Association; Research Center Julich; Helmholtz Association; Research Center Julich; RWTH Aachen University
  摘要：The only known peptide- gated ion channels-FaNaCs/WaNaCs and HyNaCs-belong to different clades of the DEG/ENaC family. FaNaCs are activated by the short neuropeptide FMRFamide, and HyNaCs by Hydra RFamides, which are not evolutionarily related to FMRFamide. The FMRFamide- binding site in FaNaCs was recently identified in a cleft atop the large extracellular domain. However, this cleft is not conserved in HyNaCs. Here, we combined molecular modeling and site- directed mutagenesis and identified...