41期

最新文章

• HIV, inflammation, and initiation of methamphetamine use in sexual and gender minorities assigned male at birth AI翻译
  作者：Carrico, Adam W.; Ryan, Daniel T.; Berona, Johnny; Dominguez, Benjamin S.; Schrock, Joshua M.; McDade, Thomas W.; Newcomb, Michael; D'Aquila, Richard T.; Mustanski, Brian
  作者单位：State University System of Florida; Florida International University; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine
  摘要：Methamphetamine use and HIV disproportionately affect sexual and gender minority (SGM) people assigned male at birth. Identifying risk factors for methamphetamine use is crucial to inform preventive interventions. In this cohort study with 1,296 SGM people assigned male at birth, ages 16 to 29, and who resided in Chicago, Poisson regression analyses indicated the prevalence of methamphetamine use increased from 2015 to 2023 [Incidence Rate Ratio (IRR) = 1.07; 95% CI = 1.01 to 1.13; P = 0.02]. ...
• Fast, variable stiffness- induced braided coiled artificial muscles AI翻译
  作者：Hu, Xinghao; Wang, Xiangyu; Wang, Jian; Zhang, Guorong; Fang, Shaoli; Zhang, Fengrui; Xiao, Ye; Cheng, Guanggui; Baughman, Ray H.; Ding, Jianning
  作者单位：Jiangsu University; University of Texas System; University of Texas Dallas; Northwestern Polytechnical University; Yangzhou University
  摘要：Biomimetic actuation technologies with high muscle strokes, cycle rates, and work capacities are necessary for robotic systems. We present a muscle type that operates based on changes in muscle stiffness caused by volume expansion. This muscle is created by coiling a mechanically strong braid, in which an elastomer hollow tube is adhesively attached inside. We show that the muscle reversibly contracts by 47.3% when driven by an oscillating input air pressure of 120 kilopascals at 10 Hz. It gen...
• Local adaptation, plasticity, and evolved resistance to hypoxic cold stress in high-altitude deer mice AI翻译
  作者：Bautista, Naim M.; Herrera, Nathanael D.; Shadowitz, Ellen; Wearing, Oliver H.; Cheviron, Zachary A.; Scott, Graham R.; Storz, Jay F.
  作者单位：University of Nebraska System; University of Nebraska Lincoln; University of Montana System; University of Montana; McMaster University; University of British Columbia; University of British Columbia; University of British Columbia Okanagan
  摘要：A fundamental question in evolutionary biology concerns the relative contributions of phenotypic plasticity vs. local adaptation (genotypic specialization) in enabling wide-ranging species to inhabit diverse environmental conditions. Here, we conduct a long-term hypoxia acclimation experiment to assess the relative roles of local adaptation and plasticity in enabling highland and lowland deer mice (Peromyscus maniculatus) to sustain aerobic thermogenesis at progressively increasing elevations....
• Complexity of confined water vitrification and its glass transition temperature AI翻译
  作者：Melillo, Jorge H.; Cangialosi, Daniele; Di Lisio, Valerio; Steinruecken, Elisa; Vogel, Michael; Cerveny, Silvina
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); University of Basque Country; CSIC - UPV EHU - Centro de Fisica de Materiales (CFM); Technical University of Darmstadt
  摘要：The ability of vitrification when crossing the glass transition temperature (T-g) of confined and bulk water is crucial for myriad phenomena in diverse fields, ranging from the cryopreservation of organs and food to the development of cryoenzymatic reactions, frost damage to buildings, and atmospheric water. However, determining water's Tg remains a major challenge. Here, we elucidate the glass transition of water by analyzing the calorimetric behavior of nano-confined water across various por...
• Migratory birds modulate niche tradeoffs in rhythm with seasons and life history AI翻译
  作者：Yanco, Scott W.; Oliver, Ruth Y.; Iannarilli, Fabiola; Carlson, Ben S.; Heine, Georg; Mueller, Uschi; Richter, Nina; Vorneweg, Bernd; Andryushchenko, Yuriy; Batbayar, Nyambayar; Dagys, Mindaugas; Desholm, Mark; Galtbalt, Batbayar; Gavrilov, Andrey E.; Goroshko, Oleg A.; Ilyashenko, Elena I.; Ilyashenko, Valentin Yu; Mansson, Johan; Mudrik, Elena A.; Natsagdorj, Tseveenmyadag; Nilsson, Lovisa; Sherub, Sherub; Skov, Henrik; Sukhbaatar, Tuvshintugs; Zydelis, Ramunas; Wikelski, Martin; Jetz, Walter; Pokrovsky, Ivan
  作者单位：Yale University; Yale University; University of California System; University of California Santa Barbara; Max Planck Society; National Academy of Sciences Ukraine; Schmalhausen Institute of Zoology of NASU; Nature Research Center - Lithuania; Russian Academy of Sciences; Russian Academy of Sciences; Saratov Scientific Center of the Russian Academy of Sciences; Severtsov Institute of Ecology & Evolution; Swedish University of Agricultural Sciences; Russian Academy of Sciences; Vavilov Institute of General Genetics; Danish Hydraulic Institute (DHI); University of Konstanz
  摘要：Movement is a key means by which animals cope with variable environments. As they move, animals construct individual niches composed of the environmental conditions they experience. Niche axes may vary over time and covary with one another as animals make tradeoffs between competing needs. Seasonal migration is expected to produce substantial niche variation as animals move to keep pace with major life history phases and fluctuations in environmental conditions. Here, we apply a time- ordered ...
• Snowmelt duration controls red algal blooms in the snow of the European Alps AI翻译
  作者：Roussel, Leon; Dumont, Marie; Gascoin, Simon; Monteiro, Diego; Bavay, Mathias; Nabat, Pierre; Ezzedine, Jade Abdellatif; Fructus, Mathieu; Lafaysse, Matthieu; Morin, Samuel; Marechal, Eric
  作者单位：Universite de Toulouse; Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Toulouse; Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); INRAE
  摘要：Algae populate multiple habitats, including snow and ice, where they can form red blooms. These decrease snow albedo, accelerating snowmelt and potentially feeding back on snow and glacier decline caused by climate change. Quantifying this feedback requires the understanding of bloom evolution with climate change. Little, however, is known about the drivers of red snow blooms. Here, we develop an algorithm to analyze 5 y of satellite data from the European Alps and separate bloom occurrences f...
• Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects (vol 109, pg 16642, 2012) AI翻译
  作者：van de Water, Jeroen A. J. M.; Bagci-Onder, Tugba; Agarwal, Aayush S.; Wakimoto, Hiroaki; Roovers, Rob C.; Zhu, Yanni; Kasmieh, Randa; Bhere, Deepak; Henegouwen, Paul M. P. Van Bergen En; Shah, Khalid
• Insulin- inspired hippocampal neuron-targeting technology for protein drug delivery AI翻译
  作者：Kamei, Noriyasu; Ikeda, Kento; Ohmoto, Yuka; Fujisaki, Seita; Shirata, Ryusei; Maki, Maya; Miyata, Mika; Miyauchi, Yuki; Nishiyama, Nanaka; Yamada, Mana; Ohigashi, Yuna; Takeda-Morishita, Mariko
  作者单位：Kobe Gakuin University
  摘要：Hippocampal neurons can be the first to be impaired with neurodegenerative disorders, including Alzheimer's disease (AD). Most drug candidates for causal therapy of AD cannot either enter the brain or accumulate around hippocampal neurons. Here, we genetically engineered insulin- fusion proteins, called hippocampal neuron-targeting (Ht) proteins, for targeting protein drugs to hippocampal neurons because insulin tends to accumulate in the neuronal cell layers of the hippocampus. In vitro exami...
• Aligned colloidal clusters in an alternating rotating magnetic field elucidated by magnetic relaxation AI翻译
  作者：Spatafora-Salazar, Aldo; Lobmeyer, Dana M.; Cunha, Lucas H. P.; Joshi, Kedar; Biswal, Sibanilisa
  作者单位：Rice University; Georgetown University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) Goa
  摘要：Precise control at the colloidal scale is one of the most promising bottom-up approaches to fabricating new materials and devices with tunable and precisely engineered properties. Magnetically driven colloidal assembly offers great versatility because of the ability to externally tune particle-particle interactions and to construct a host of particle arrangements. However, despite previous efforts to probe the parameter space, global orientational control in conjunction with two-dimensional mi...
• Heart-on-a-Chip at the final frontier AI翻译
  作者：McCain, Megan L.
  作者单位：University of Southern California; University of Southern California