Jamaican fruit bats mount a stable and highly neutralizing antibody response after bat influenza virus infection

• 成果类型: Article
• 署名作者: Kessler, Susanne; Stegen, Philipp; Zhan, Shijun; Schwemmle, Martin; Reuther, Peter; Schountz, Tony; Ciminski, Kevin
• 署名单位: University of Freiburg; University of Freiburg; Colorado State University System; Colorado State University Fort Collins
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-14380
• DOI: 10.1073/pnas.2413619121
• 发表日期: 2024-10-15
• 关键词: marburg virus; pteropid bats; transmission

摘要

Antibodies are an essential component of the antiviral response in many species, but to immunity, including neutralizing antibodies. Here, we report that infection of Jamaican fruit bats with the bat influenza A virus H18N11 elicits a rapid and stable humoral immune response with a strong neutralizing capacity, associated with no detectable viral shedding after repeat challenge infection. Thus, the neutralizing antibody response of bats might play an important role in the bat immunity.