44期

最新文章

• Developing forebrain synapses are uniquely vulnerable to sleep loss AI翻译
  作者：Gay, Sean M.; Chartampila, Elissavet; Lord, Julia S.; Grizzard, Sawyer; Maisashvili, Tekla; Ye, Michael; Barker, Natalie K.; Mordant, Angie L.; Mills, C. Allie; Herring, Laura E.; Diering, Graham H.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：Sleep is an essential behavior that supports lifelong brain health and cognition. Neuronal synapses are a major target for restorative sleep function and a locus of dysfunction in response to sleep deprivation (SD). Synapse density is highly dynamic during development, becoming stabilized with maturation to adulthood, suggesting sleep exerts distinct synaptic functions between development and adulthood. Importantly, problems with sleep are common in neurodevelopmental disorders including autis...
• Bacterial defense and phage counterdefense lead to coexistence in a modeled ecosystem AI翻译
  作者：Kimchi, Ofer; Meir, Yigal; Wingreen, Ned S.
  作者单位：Princeton University; Ben-Gurion University of the Negev; Princeton University; Princeton University
  摘要：Bacteria have evolved many defenses against invading viruses (phage). Despite the many bacterial defenses and phage counterdefenses, in most environments, bacteria and phage coexist, with neither driving the other to extinction. How is coexistence realized in the context of the bacteria/phage arms race, and how are immune repertoire sizes determined in conditions of coexistence? Here we develop a simple mathematical model to consider the evolutionary and ecological dynamics of competing bacter...
• Landscape and environmental heterogeneity support coexistence in competitive metacommunities AI翻译
  作者：Padmanabha, Prajwal; Nicoletti, Giorgio; Bernardi, Davide; Suweis, Samir; Azaele, Sandro; Rinaldo, Andrea; Maritan, Amos
  作者单位：University of Padua; University of Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; National Biodiversity Future Center; Istituto Nazionale di Fisica Nucleare (INFN); University of Padua
  摘要：Metapopulation models have been instrumental in quantifying the ecological impact of landscape structure on the survival of a focal species. However, extensions to multiple species with arbitrary dispersal networks often rely on phenomenological assumptions that inevitably limit their scope. Here, we propose a multilayer network model of competitive dispersing metacommunities to investigate how spatially structured environments impact species coexistence and ecosystem stability. We introduce t...
• Methane fueled lake pelagic food webs in a Cretaceous greenhouse world AI翻译
  作者：Sun, Funing; Luo, Genming; Pancost, Richard D.; Dong, Zhengkun; Li, Zhiguo; Wang, Hongmei; Chen, Zhong-Qiang; Xie, Shucheng
  作者单位：China University of Geosciences; China University of Geosciences; University of Bristol; China University of Geosciences
  摘要：Methane (CH4) is a potent greenhouse gas but also an important carbon and energy substrate for some lake food webs. Understanding how CH4 incorporates into food webs is, therefore, crucial for unraveling CH4 cycling and its impacts on climate and ecosystems. However, CH4-fueled lake food webs from pre-Holocene intervals, particularly during greenhouse climates in Earth history, have received relatively little attention. Here, we present a long-term record of CH4-fueled pelagic food webs across...
• Insects decline with host plants but coextinctions may be limited AI翻译
  作者：Bassi, Marlon I. E.; Staude, Ingmar R.
  作者单位：Leipzig University; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv)
  摘要：The loss ofwild plant populations is often assumed to lead to coextinctions, particularly among specialized insects. Despite global declines in both terrestrial insects and plants, the relationship between these trends remains elusive. Here, we address this gap by analyzing the relationship between population trends of insects and their host plants in Germany, encompassing over 150,000 interactions among 3,429 plant and 2,239 insect species, including both pollinators (bees and hoverflies) and...
• WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc AI翻译
  作者：Jiang, Li; Qi, Xuxin; Lai, Minshan; Zhou, Jiahao; Yuan, Meng; You, Jieqiong; Liu, Qiang; Pan, Jinchang; Zhao, Luyao; Ying, Meidan; Ji, Junfang; Li, Ke; Zhang, Yan; Pan, Weiwei; He, Qiaojun; Yang, Bo; Cao, Ji
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Westlake University; Zhejiang University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Liangzhu Laboratory; Zhejiang University; Zhejiang University; Jiaxing University; Hangzhou City University
  摘要：The dysfunction of the ubiquitin-proteasome system (UPS) facilitates the malignant progression of hepatocellular carcinoma (HCC). While targeting the UPS for HCC therapy has been proposed, identifying effective targets has been challenging. In this study, we conducted a focused screen of siRNA libraries targeting UPS- related WD40 repeat (WDR) proteins and found that silencing WDR20, a deubiquitinating enzyme activating factor, selectively inhibited the proliferation of HCC cells without affec...
• Reply to Chong et al.: Investigating TGFβ1 biological activities using genetically engineered mouse strains AI翻译
  作者：Riehl, Dennis R.; Sharma, Arjun; Roewe, Julian; Reinhardt, Christoph; Schaefer, Katrin; Bosmann, Markus
  作者单位：Johannes Gutenberg University of Mainz; Boston University; Johannes Gutenberg University of Mainz; German Centre for Cardiovascular Research; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz
• Political organization and gender predict violence in the Andean archaeological record AI翻译
  作者：Snyder, Thomas J.; Arkush, Elizabeth
  作者单位：University of California System; University of California Davis; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：The relationship between sociopolitical organization and violence remains an enduring question in anthropological research. Less studied is the articulation of gender with lence in societies of different sociopolitical organization. We investigate the frequency and type of violence experienced by adult males and females in pre- Hispanic Andean archaeological contexts, comparing exposure to antemortem (nonlethal) and perimortem (potentially lethal) violence across three categories of sociopolit...
• Artificial light at night reveals hotspots and rapid development of industrial activity in the Arctic AI翻译
  作者：Akandil, Cengiz; Plekhanova, Elena; Rietze, Nils; Oehri, Jacqueline; Roman, Miguel O.; Wang, Zhuosen; Radeloff, Volker C.; Strub, Gabriela Schaepman -
  作者单位：University of Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University System of Maryland; University of Maryland College Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University of Wisconsin System; University of Wisconsin Madison
  摘要：Climate warming enables easier access and operation in the Arctic, fostering industrial and urban development. However, there is no comprehensive pan- Arctic overview of industrial and urban development, which is crucial for the planning of sustainable development of the region. In this study, we utilize satellite- derived artificial light at night (ALAN) data to quantify the hotspots and the development of light- emitting human activity across the Arctic from 1992 to 2013. We find that out of...
• Biomechanics of phagocytosis of red blood cells by macrophages in the human spleen AI翻译
  作者：Li, He; Qiang, Yuhao; Li, Xuejin; Brugnara, Carlo; Buffet, Pierre A.; Dao, Ming; Karniadakis, George E.; Suresh, Subra
  作者单位：University System of Georgia; University of Georgia; Massachusetts Institute of Technology (MIT); Zhejiang University; Zhejiang University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Brown University; Brown University
  摘要：The clearance of senescent and altered red blood cells (RBCs) in the red pulp of the human spleen involves sequential processes of prefiltration, filtration, and postfiltration. While prior work has elucidated the mechanisms underlying the first two processes, biomechanical processes driving the postfiltration phagocytosis of RBCs retained at interendothelial slits (IES) are still poorly understood. We present here a unique computational model of macrophages to study the role of cell biomechan...