44期

最新文章

• Targeting Unc5b in macrophages drives atherosclerosis regression and pro- resolving immune cell function AI翻译
  作者：Schlegel, Martin; Cyr, Yannick; Newman, Alexandra A. C.; Schreyer, Korbinian; Duran, Jose Gabriel Barcia; Sharma, Monika; Bozal, Fazli K.; Gourvest, Morgane; La Forest, Maxwell; Afonso, Milessa S.; van Solingen, Coen; Fisher, Edward A.; Moore, Kathryn J.
  作者单位：Technical University of Munich; New York University; New York University; Gilead Sciences
  摘要：Atherosclerosis results from lipid- driven inflammation of the arterial wall that fails to resolve. Imbalances in macrophage accumulation and function, including diminished migratory capacity and defective efferocytosis, fuel maladaptive inflammation and plaque progression. The neuroimmune guidance cue netrin-1 has dichotomous roles in inflammation partly due to its multiple receptors; in atherosclerosis, netrin-1 promotes macrophage survival and retention via its receptor Unc5b. To minimize t...
• Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding AI翻译
  作者：Frischauf, Nikolaus; Borg, Ellen G. F.; Labrijn, Aran F.; Beurskens, Frank J.; Preiner, Johannes
  作者单位：Genmab
  摘要：Complement activation through antibody-antigen complexes is crucial in various pathophysiological processes and utilized in immunotherapies to eliminate infectious agents, regulatory immune cells, or cancer cells. The tertiary structures of the four IgG antibody subclasses are largely comparable, with the most prominent difference being the hinge regions connecting the Fab and Fc domains, providing them with unique structural flexibility. Complement recruitment and activation depend strongly o...
• Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARβ and tumor regression (vol 110, pg 9812, 2013) AI翻译
  作者：Galli, Roberta; Paone, Alessio; Fabbri, Muller; Zanesi, Nicola; Calore, Federica; Cascione, Luciano; Acunzo, Mario; Stoppacciaro, Antonella; Tubaro, Andrea; Lovat, Francesca; Gasparini, Pierluigi; Fadda, Paolo; Alder, Hansjuerg; Volinia, Stefano; Filippini, Antonio; Ziparo, Elio; Riccioli, Anna; Croce, Carlo M.
• Structure and function of Mycobacterium tuberculosis EfpA as a lipid transporter and its inhibition by BRD-8000.3 AI翻译
  作者：Li, Delin; Zhang, Xiaokang; Yao, Yuanhang; Sun, Xue; Sun, Junqing; Ma, Xiaomin; Yuan, Kai; Bai, Guijie; Pang, Xuefei; Hua, Rongmao; Guo, Tianling; Mi, Yuqian; Wu, Lingzhi; Zhang, Jie; Wu, Yan; Liu, Yingxia; Wang, Peiyi; Wong, Catherine C. L.; Chen, Xiao-wei; Xiao, Haixia; Gao, George Fu; Gao, Feng
  作者单位：Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Peking University; Peking University; Southern University of Science & Technology; Capital Medical University; Southern University of Science & Technology; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Peking University; Chinese Academy of Sciences; Institute of Microbiology, CAS
  摘要：EfpA, the first major facilitator superfamily (MFS) protein identified in Mycobacterium tuberculosis (Mtb), is an essential efflux pump implicated in resistance to multiple drugs. EfpA- inhibitors have been developed to kill drug- tolerant Mtb. However, the biological function of EfpA has not yet been elucidated. Here, we present the cryo- EM structures of EfpA complexed with lipids or the inhibitor BRD- 8000.3 at resolutions of 2.9 & Aring; and reveal that EfpA is a lipid transporter and BRD-...
• Reply to Masters: Recombinant coronavirus balances biosafety and benefit AI翻译
  作者：Yewdell, Jonathan W.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
• Convolution identities for divisor sums and modular forms AI翻译
  作者：Fedosova, Ksenia; Klinger-Logan, Kim; Radchenko, Danylo
  作者单位：University of Munster; Kansas State University; Universite de Lille
  摘要：We consider certain convolution sums that are the subject of a conjecture by Chester, Green, Pufu, Wang, and Wen in string theory. We prove a generalized form of their conjecture, explicitly evaluating absolutely convergent sums X n1 is an element of ZN{0,n} cP ( n 1 , n - n 1 ) 6 2 m 1 ( n 1 ) 6 2 m 2 ( n - n 1 ), where tp ( n 1 , n 2 ) is a Laurent polynomial with logarithms. Contrary to original expectations, such convolution sums, suitably extended to n 1 is an element of { 0 , n }, do not...
• Caution urged for work with newly constructed human coronavirus AI翻译
  作者：Masters, Paul S.
  作者单位：Wadsworth Center
• Electric fields imbue enzyme reactivity by aligning active site fragment orbitals AI翻译
  作者：Eberhart, M. E.; Wilson, Timothy R.; Jones, T. E.; Alexandrova, Anastassia N.
  作者单位：Colorado School of Mines; United States Department of Energy (DOE); Los Alamos National Laboratory; University of California System; University of California Los Angeles
  摘要：It is broadly recognized that intramolecular electric fields, produced by the protein scaffold and acting on the active site, facilitate enzymatic catalysis. This field effect can be described by several theoretical models, each of which is intuitive to varying degrees. In this contribution, we show that a fundamental effect of electric fields is to generate electrostatic potentials that facilitate the energetic alignment of reactant frontier orbitals. We apply this model to demystify the impa...
• A myeloid differentiation-like protein in partnership with Toll5 from the pest insect Spodoptera litura senses baculovirus infection AI翻译
  作者：Zhang, Ruonan; Zhong, Jielai; Li, Yanjun; Li, Mengge; Zhang, Jie; Hu, Qihao; Wen, Liang; Xu, Xiaoxia; Jin, Fengliang; Yang, Wanying; Lu, Yuzhen; Strand, Michael R.; Yu, Xiao-Qiang
  作者单位：South China Normal University; South China Agricultural University; South China Agricultural University; University System of Georgia; University of Georgia
  摘要：Many types of viruses infect insects and other arthropods. In contrast, little is known about how arthropods sense viruses, although several innate immune pathways including Toll have antiviral functions. Large DNA viruses in the family Baculoviridae are used to control a number of pest insects. Here, we studied Spodoptera litura and Autographa californica multiple nucleopolyhedrovirus (AcMNPV) to test the hypothesis that one or more myeloid differentiation-like (ML) proteins and Toll family m...
• Reconfigurable, zero-energy, and wide-temperature loss-assisted thermal nonreciprocal metamaterials AI翻译
  作者：Lei, Min; Jin, Peng; Zhou, Yuhong; Li, Ying; Xu, Liujun; Huang, Jiping
  作者单位：Fudan University; Fudan University; Zhejiang University; Zhejiang University; Zhejiang University; Chinese Academy of Engineering Physics
  摘要：Thermal nonreciprocity plays a vital role in chip heat dissipation, energy-saving design, and high-temperature hyperthermia, typically realized through the use of advanced metamaterials with nonlinear, advective, spatiotemporal, or gradient properties. However, challenges such as fixed structural designs with limited adjustability, high energy consumption, and a narrow operational temperature range remain prevalent. Here, a systematic framework is introduced to achieve reconfigurable, zero-ene...