44期

最新文章

• Longitudinal hippocampal axis in large- scale cortical systems underlying development and episodic memory AI翻译
  作者：Xie, Hua; Illapani, Venkata Sita Priyanka; Reppert, Lauren T.; You, Xiaozhen; Krishnamurthy, Manu; Bai, Yutong; Berl, Madison M.; Gaillard, William D.; Hong, Seok - Jun; Sepeta, Leigh N.
  作者单位：Children's National Health System; George Washington University; Sungkyunkwan University (SKKU); Institute for Basic Science - Korea (IBS); George Washington University
  摘要：The hippocampus is functionally specialized along its longitudinal axis with intricate interactions with cortical systems, which is crucial for understanding development and cognition. Using a well- established connectopic mapping technique on two large resting- state functional MRI datasets, we systematically quantified topographic organization of the hippocampal functional connectivity (hippocampal gradient) and its cortical interaction in developing brains. We revealed hippocampal functiona...
• The Greenland spatial fingerprint of Dansgaard-Oeschger events in observations and models AI翻译
  作者：Buizert, Christo; Sowers, Todd A.; Niezgoda, Kyle; Blunier, Thomas; Gkinis, Vasileios; Harlan, Margaret; He, Chengfei; Jones, Tyler R.; Kjaer, Helle A.; Liisberg, Jesper B.; Menking, James A.; Morris, Valerie; Noone, David; Rasmussen, Sune Olander; Sime, Louise C.; Steffensen, Jurgen P.; Svensson, Anders; Vaughng, Bruce H.; Vinther, Bo M.; White, James W. C.
  作者单位：Oregon State University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Rice University; University of Copenhagen; Niels Bohr Institute; University of Tasmania; University of Miami; University of Colorado System; University of Colorado Boulder; Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Environment; University of Tasmania; University of Auckland; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; University of North Carolina; University of North Carolina Chapel Hill
  摘要：Pleistocene Ice Ages display abrupt Dansgaard-Oeschger (DO) climate oscillations that provide prime examples of Earth System tipping points-abrupt transition that may result in irreversible change. Greenland ice cores provide key records of DO climate variability, but gas- calibrated estimates of the temperature change magnitudes have been limited to central and northwest Greenland. Here, we present ice- core delta 15 N-N records from south (Dye 3) and coastal east Greenland (Renland) to calib...
• Theropod trackways as indirect evidence of pre- avian aerial behavior AI翻译
  作者：Dececchi, T. Alexander; Kim, Kyung Soo; Lockley, Martin G.; Larsson, Hans C. E.; Holtz, Thomas R.; Farlow, James O.; Pittman, Michael
  作者单位：Dakota State University; University of Colorado System; University of Colorado Denver; McGill University; University System of Maryland; University of Maryland College Park; Smithsonian Institution; Smithsonian National Museum of Natural History; Purdue University System; Indiana University Purdue University Fort Wayne; Chinese University of Hong Kong
  摘要：Body fossils set limits on feasible reconstructions of functional capacity and behavior in theropod dinosaurs, but do not document in- life behaviors. In contrast, trace fossils such as footprints preserve in- life behaviors that can potentially test and enhance existing reconstructions. Here, we demonstrate how theropod trackways can be used as indirect evidence of pre- avian aerial behavior, expanding the approaches available to study vertebrate flight origins. This involved exploring the be...
• AlphaFold-Multimer accurately captures interactions and dynamics of intrinsically disordered protein regions AI翻译
  作者：Omidi, Alireza; Moller, Mads Harder; Malhis, Nawar; Bui, Jennifer M.; Gsponer, Jorg
  作者单位：University of British Columbia; University of British Columbia
  摘要：Interactions mediated by intrinsically disordered protein regions (IDRs) pose formidable challenges in structural characterization. IDRs are highly versatile, capable of adopting diverse structures and engagement modes. Motivated by recent strides in protein structure prediction, we embarked on exploring the extent to which AlphaFoldMultimer can faithfully reproduce the intricacies of interactions involving IDRs. To this end, we gathered multiple datasets covering the versatile spectrum of IDR...
• Interferon lambda 4 is a gut antimicrobial protein AI翻译
  作者：Xiao, Xun; Wang, Jinting; Ma, Jun; Peng, Xuan; Wu, Shengqiang; Chen, Xiaolei; Lu, Hao; Tan, Chen; Fang, Liurong; Xiao, Shaobo
  作者单位：Huazhong Agricultural University
  摘要：To withstand complex microbial challenges, the mammalian gut largely depends on the secretion of diverse antimicrobial proteins. Type III interferons (IFN lambda s) are ordinarily considered inducible antiviral cytokines involved in intestinal immunity. Unlike other IFN lambda s, we found that newly identified IFN lambda 4 is an intestinal antibacterial protein. Large amounts of natural IFN lambda 4 are present in the secretory layer of the intestinal tracts of healthy piglets, which suggests ...
• eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations AI翻译
  作者：Valcikova, Barbora; Vadovicova, Natalia; Smolkova, Karolina; Zacpalova, Magdalena; Krejci, Pavel; Lee, Shannon; Rauch, Jens; Kolch, Walter; von Kriegsheim, Alexander; Dorotikova, Anna; Andrysik, Zdenek; Vichova, Rachel; Vacek, Ondrej; Soucek, Karel; Uldrijan, Stjepan
  作者单位：Masaryk University; St. Anne's University Hospital Brno (FNUSA); St. Anne's University Hospital Brno (FNUSA-ICRC); Czech Academy of Sciences; Institute of Animal Physiology & Genetics of the Czech Academy of Sciences; University College Dublin; University College Dublin; University College Dublin; University of Edinburgh; University of Colorado System; University of Colorado Anschutz Medical Campus; Czech Academy of Sciences; Institute of Biophysics of the Czech Academy of Sciences; Masaryk University
  摘要：The eIF4F translation initiation complex plays a critical role in melanoma resistance to clinical BRAF and MEK inhibitors. In this study, we uncover a function of eIF4F in the negative regulation of the rat sarcoma (RAS)/rapidly accelerated fibrosarcoma (RAF)/mitogen- activated protein kinase kinase (MEK)/extracellular signal- regulated kinase (ERK) mitogen- activated protein kinase (MAPK) signaling pathway. We demonstrate that eIF4F is essential for controlling ERK signaling intensity in trea...
• E- cigs put the squeeze on macrophages AI翻译
  作者：Arnett, Eusondia; Schlesinger, Larry S.
  作者单位：Texas Biomedical Research Institute
• Collective phase transitions in confined fish schools AI翻译
  作者：Huang, Chenchen; Ling, Feng; Kanso, Eva
  作者单位：University of Southern California; University of Southern California
  摘要：The collective patterns that emerge in schooling fish are often analyzed using models of self-propelled particles in unbounded domains. However, while schooling fish in both field and laboratory settings interact with domain boundaries, these effects are typically ignored. Here, we propose a model that incorporates geometric confinement, by accounting for both flow and wall interactions, into existing data driven behavioral rules. We show that new collective phases emerge where the school of f...
• Dominant and genome- wide formation of DNA:RNA hybrid G- quadruplexes in living yeast cells AI翻译
  作者：Ren, Chen-xia; Duan, Rui-fang; Wang, Jia; Hao, Yu-hua; Tan, Zheng
  作者单位：Changzhi Medical College; Chinese Academy of Sciences; Institute of Zoology, CAS
  摘要：Guanine- rich DNA forms G- quadruplexes (G4s) that play a critical role in essential cellular processes. Previous studies have mostly focused on intramolecular G4s composed of four consecutive guanine tracts (G- tracts) from a single strand. However, this structural form has not been strictly confirmed in the genome of living eukaryotic cells. Here, we report the formation of hybrid G4s (hG4s), consisting of G- tracts from both DNA and RNA, in the genome of living yeast cells. Analysis of Okaz...
• High-yield atmospheric water capture via bioinspired material segregation AI翻译
  作者：Gao, Yiwei; Eason, Areianna; Ricoy, Santiago; Cobb, Addison; Phung, Ryan; Kashani, Amir; Mata, Mario R.; Sahm, Aaron; Ortiz, Nathan; Rao, Sameer; Cho, H. Jeremy
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; University of Michigan System; University of Michigan; Utah System of Higher Education; University of Utah
  摘要：Transforming atmospheric water vapor into liquid form can be a way to supply water to arid regions for uses such as drinking water, thermal management, and hydrogen generation. Many current methods rely on solid sorbents that cycle between capture and release at slow rates. We envision a radically different approach where water is transformed and directly captured into a liquid salt solution that is suitable for subsequent distillation or other processing using existing methods. In contrast to...