44期

最新文章

• Dual ON/OFF- switch chimeric antigen receptor controlled by two clinically approved drugs AI翻译
  作者：Attianese, Greta Maria Paola Giordano; Shui, Sailan; Cribioli, Elisabetta; Triboulet, Melanie; Scheller, Leo; Hafezi, Morteza; Reichenbach, Patrick; Gainza, Pablo; Georgeon, Sandrine; Correia, Bruno E.; Irving, Melita
  作者单位：University of Lausanne; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Institute of Bioinformatics
  摘要：The ability to remotely control the activity of chimeric antigen receptors (CARs) with small molecules can improve the safety and efficacy of gene- modified T cells. Split ON- or OFF- switch CARs involve the dissociation of tumor-antigen binding from that either associate or are disrupted in the presence of a small molecule. Here, we have developed an inducible (i)ON- CAR comprising the anti- apoptotic B cell lymphoma protein 2 protein in the ectodomain of both chains which associate in the pr...
• Invasive plants and their root traits are linked to the homogenization of soil microbial communities across the United States AI翻译
  作者：Nunez-Mir, Gabriela C.; McCary, Matthew A.
  作者单位：University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Rice University
  摘要：Although the impacts of invasive plants on soil ecosystems are widespread, the role and impacts of invader root traits in structuring microbial communities remain poorly understood. Here, we present a macroecological study investigating how plant invaders and their root traits affect soil microbial communities, spanning data from 377 unique plots across the United States sampled multiple times, totaling 632 sampling events and 94 invasive plant species. We found that native and invasive plants...
• Meta- learning of human motor adaptation via the dorsal premotor cortex AI翻译
  作者：Sugiyama, Taisei; Uehara, Shintaro; Izawa, Jun
  作者单位：University of Tsukuba; Fujita Health University
  摘要：Meta- learning enables us to learn how to learn the same or similar tasks more efficiently. Decision- making literature theorizes that a prefrontal network, including the orbitofrontal and anterior cingulate cortices, underlies meta- learning of decision making by reinforcement learning. Recently, computationally similar meta- learning has been theorized and empirically demonstrated in motor adaptation. However, it remains unclear whether meta- learning of motor adaptation also relies on a pre...
• Quantitative omnigenic model discovers interpretable genome-wide associations AI翻译
  作者：Ruzickova, Natalia; Hledik, Michal; Tkacik, Gasper
  作者单位：Institute of Science & Technology - Austria
  摘要：As their statistical power grows, genome-wide association studies (GWAS) have identified an increasing number of loci underlying quantitative traits of interest. These loci are scattered throughout the genome and are individually responsible only for small fractions of the total heritable trait variance. The recently proposed omnigenic model provides a conceptual framework to explain these observations by postulating that numerous distant loci contribute to each complex trait via effect propag...
• QSOX1 facilitates dormant esophageal cancer stem cells to evade immune elimination via PD-L1 upregulation and CD8 T cell exclusion AI翻译
  作者：Wei, Jia-Ru; Zhang, Baifeng; Zhang, Yu; Chen, Wo-Ming; Zhang, Xiao-Ping; Zeng, Ting-Ting; Li, Yan; Zhu, Ying-Hui; Guan, Xin-Yuan; Li, Lei
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; University of Hong Kong; Sun Yat Sen University; State Key Lab Oncology South China; Sun Yat Sen University; Sun Yat Sen University; University of Hong Kong
  摘要：Dormant cancer stem cells (DCSCs) exhibit characteristics of chemotherapy resistance and immune escape, and they are a crucial source of tumor recurrence and metastasis. However, the underlying mechanisms remain unrevealed. We demonstrate that enriched Gzmk+ CD8+ T cells within the niche of esophageal DCSCs restrict the outgrowth of tumor mass. Nonetheless, DCSCs can escape immune elimination by enhancing PD- L1 signaling, thereby maintaining immune equilibrium. Quiescent fibroblast- derived q...
• Cryo- EM structure of the zinc- activated channel (ZAC) in the Cys- loop receptor superfamily AI翻译
  作者：Jin, Fei; Lin, Yi-Yu; Wang, Ru-Chun; Xie, Tang-Xuan; Zhao, Yimeng; Shen, Cheng; Sheng, Danqi; Ichikawa, Muneyoshi; Yu, Ye; Wang, Jin; Hattori, Motoyuki
  作者单位：Fudan University; China Pharmaceutical University; Fudan University; Fudan University; China Pharmaceutical University
  摘要：Cys-loop receptors are a large superfamily of pentameric ligand-gated ion channels with various physiological roles, especially in neurotransmission in the central nervous system. Among them, zinc- activated channel (ZAC) is a Zn2+- activated ion channel that is widely expressed in the human body and is conserved amongeukaryotes. Due to its gating by extracellular Zn2+, ZAC has been considered a Zn2+ sensor, but it has undergone minimal structural and functional characterization since its mole...
• Type VI secretion systems promote intraspecific competition and host interactions in a bee gut symbiont AI翻译
  作者：Motta, Erick V. S.; Lariviere, Patrick J.; Jones, Korin R.; Song, Yulin; Moran, Nancy A.
  作者单位：University of Texas System; University of Texas Austin; Texas A&M University System; Texas A&M University College Station; University of Texas System; University of Texas Austin
  摘要：The Type VI Secretion System (T6SS) is a sophisticated mechanism utilized by gram- negative bacteria to deliver toxic effector proteins into target cells, influencing microbial community dynamics and host interactions. In this study, we investigated the role of T6SSs in Snodgrassella alvi wkB2, a core bacterial symbiont of the honey bee gut microbiota. We generated single- and double- knockout mutants targeting essential genes ( tssD and tssE) in both T6SS-1 and T6SS-2 and assessed their colon...