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作者：Scavia, Donald; Ludsin, Stuart A.; Michalak, Anna M.; Obenour, Daniel R.; Han, Mingyu; Johnson, Laura T.; Wang, Yu-Chen; Zhao, Gang; Zhou, Yuntao
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作者：Gu, Xiao; Bui, Linh P.; Wang, Fenglei; Wang, Dong D.; Springmann, Marco; Willett, Walter C.
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Oxford; University of London; University College London; Harvard University; Harvard T.H. Chan School of Public Health
摘要：The Planetary Health Diet (PHD), also known as the EAT- Lancet reference diet, was developed to optimize global dietary quality while keeping the environmental impacts of food production within sustainable planetary boundaries. We calculated current national and global adherence to the PHD using the Planetary Health Dietary Index (PHDI). In addition, we used data on diet and mortality from three large US cohorts (n = 206,404 men and women, 54,536 deaths) to estimate the total and cause- specif...
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作者：Isaacs, Dominic; Xiang, Liuruimin; Hariharan, Ashwini; Longden, Thomas A.
作者单位：University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore
摘要：The brain has evolved mechanisms to dynamically modify blood flow, enabling the timely delivery of energy substrates in response to local metabolic demands. Several such neurovascular coupling (NYC) mechanisms have been identified, but the vascular signal transduction and transmission mechanisms that enable dilation of penetrating arterioles (PAs) remote from sites of increased neuronal activity are unclear. Given the exponential relationship between vessel diameter and blood flow, tight contr...
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作者：Lee, Sangil; Niu, Runxuan; Zhu, Lusha; Kayser, Andrew S.; Hsu, Ming
作者单位：University of California System; University of California Berkeley; Peking University; Peking University; University of California System; University of California San Francisco; University of California System; University of California Berkeley
摘要：Deception is a universal human behavior. Yet longstanding skepticism about the validity of measures used to characterize the biological mechanisms underlying deceptive behavior has relegated such studies to the scientific periphery. Here, we address these fundamental questions by applying machine learning methods and functional magnetic resonance imaging (fMRI) to signaling games capturing motivated deception in human participants. First, we develop an approach to test for the presence of conf...
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作者：Lobel, Graham P.; Han, Nanumi; Arocho, William A. Molina; Silber, Michal; Shoush, Jason; Noji, Michael C.; To, Tsun Ki Jerrick; Zhai, Li; Lesner, Nicholas P.; Simon, M. Celeste; Haldar, Malay
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Proliferating tumor cells take up glutamine for anabolic processes, engendering glutamine deficiency in the tumor microenvironment. How this might impact immune cells is not well understood. Using multiple mouse models of soft tissue sarcomas, glutamine antagonists, as well as genetic and pharmacological inhibition of glutamine utilization, we found that the number and frequency of conventional dendritic cells (cDCs) is dependent on microenvironmental glutamine levels. cDCs comprise two distin...
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作者：Lu, I-Te; Shin, Dongbin; Svendsen, Mark Kamper; Hubener, Hannes; De Giovannini, Umberto; Latini, Simone; Ruggenthaler, Michael; Rubio, Angel
作者单位：Max Planck Society; Gwangju Institute of Science & Technology (GIST); University of Copenhagen; Niels Bohr Institute; University of Palermo; Technical University of Denmark; Simons Foundation; Flatiron Institute
摘要：Strong laser pulses can control superconductivity, inducing nonequilibrium transient pairing by leveraging strong-light matter interaction. Here, we demonstrate theoretically that equilibrium ground-state phonon-mediated superconductive pairing can be affected through the vacuum fluctuating electromagnetic field in a cavity. Using the recently developed ab initio quantum electrodynamical density-functional theory approximation, we specifically investigate the phonon-mediated superconductive be...
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作者：Iu, David S.; Maya, Jessica; Vu, Luyen T.; Fogarty, Elizabeth A.; Mcnairn, Adrian J.; Ahmed, Faraz; Franconi, Carl J.; Munn, Paul R.; Grenier, Jennifer K.; Hanson, Maureen R.; Grimson, Andrew
作者单位：Cornell University; Cornell University; Cornell University
摘要：Myalgic encephalomyelitis/chronic fatigue syndrome (ME) is a severe, debilitating disease, with substantial evidence pointing to immune dysregulation as a key contributor to pathophysiology. To characterize the gene regulatory state underlying T cell dysregulation in ME, we performed multiomic analysis across T cell subsets by integrating single- cell RNA-seq, RNA-seq, and ATAC-seq and further analyzed CD8+ T cell subpopulations following symptom provocation. Specific subsets of CD8+ T cells, ...
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作者：Jahn, Steffen; Guhl, Daniel; Erhard, Ainslee
作者单位：Martin Luther University Halle Wittenberg; Humboldt University of Berlin; University of Gottingen
摘要：Efforts to promote sustainable resource use through reduced meat consumption face challenges as global meat consumption persists. The resistance may be attributed to the lower sales price of meat compared to most plant- based meat alternatives (PBMAs). Addressing this, our research delves into the pivotal question of which PBMAs resonate most with consumers and how pricing affects demand. In a hypothetical restaurant context, we conducted 2 representative studies among 2,126 individuals in the...
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作者：Lin, Haiyang; Gonzalez, Andres Hernandez; Nielsen, Chris P.; Mcelroy, Michael B.
作者单位：Harvard University; Harvard University; Harvard University
摘要：As the largest oil and gas producer in the United States, Texas confronts significant challenges in its shift toward decarbonization. This study explores the potential for green hydrogen in Texas as a substitute for current development, underscoring numerous advantages such as ample renewables, established demand, and operational infrastructure. We present an hourly- resolution, cross- sector assessment framework to optimize grid- integrated green hydrogen supply paths from managing local appl...
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作者：Zhang, Yi; Hu, Qingjuan; Su, Yingtong; Chu, Pan; Wei, Ting; Li, Xuefei; Liu, Chenli; Fu, Xiongfei
作者单位：Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Motile organisms can expand into new territories and increase their fitness, while non- motile viruses usually depend on host migration to spread across long distances. In general, faster host motility facilitates virus transmission. However, recent ecological studies have also shown that animal host migration can reduce viral prevalence by removing infected individuals from the migratory group. Here, we use a bacteria- bacteriophage copropagation system to investigate how host motility affect...
