Navigated range expansion promotes migratory culling

• 成果类型: Article
• 署名作者: Zhang, Yi; Hu, Qingjuan; Su, Yingtong; Chu, Pan; Wei, Ting; Li, Xuefei; Liu, Chenli; Fu, Xiongfei
• 署名单位: Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-11541
• DOI: 10.1073/pnas.2408303121
• 发表日期: 2024-12-10
• 关键词: escherichia-coli; infection; bacteria; SPREAD; diversity; EVOLUTION; parasites; strategy; LIFE

摘要

Motile organisms can expand into new territories and increase their fitness, while non- motile viruses usually depend on host migration to spread across long distances. In general, faster host motility facilitates virus transmission. However, recent ecological studies have also shown that animal host migration can reduce viral prevalence by removing infected individuals from the migratory group. Here, we use a bacteria- bacteriophage copropagation system to investigate how host motility affects viral spread during range expansion. We find that phage spread during chemotaxis- driven navigated range expansion decreases as bacterial migration speed increases. Theoretical and experimental analyses show that the navigated migration leads to a spatial sorting of infected and uninfected hosts in the copropagating front of bacteria- bacteriophage, with implications for the number of cells left behind. The preferential loss of infected cells in the copropagating front inhibits viral spread. Further increase in host migration speed leads to a phase transition that eliminates the phage completely. These results illustrate that navigated range expansion of the host can promote the migratory culling of infectious diseases in the migration group.