Distinguishing deception from its confounds by improving the validity of fMRI- based neural prediction

• 成果类型: Article
• 署名作者: Lee, Sangil; Niu, Runxuan; Zhu, Lusha; Kayser, Andrew S.; Hsu, Ming
• 署名单位: University of California System; University of California Berkeley; Peking University; Peking University; University of California System; University of California San Francisco; University of California System; University of California Berkeley
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-11306
• DOI: 10.1073/pnas.2412881121
• 发表日期: 2024-12-10
• 关键词: detecting deception; prefrontal cortex; lie detection; pattern-information; brain activity; REPRESENTATIONS; metaanalysis; honesty; STATES

摘要

Deception is a universal human behavior. Yet longstanding skepticism about the validity of measures used to characterize the biological mechanisms underlying deceptive behavior has relegated such studies to the scientific periphery. Here, we address these fundamental questions by applying machine learning methods and functional magnetic resonance imaging (fMRI) to signaling games capturing motivated deception in human participants. First, we develop an approach to test for the presence of confounding processes and validate past skepticism by showing that much of the predictive power of neural predictors trained on deception data comes from processes other than deception. Specifically, we demonstrate that discriminant validity is compromised by the predictor's ability to predict behavior in a control task that does not involve deception. Second, we show that the presence of confounding signals need not be fatal and that the validity of the neural predictor can be improved by removing confounding signals while retaining those associated with the task of interest. To this end, we develop a dual- goal tuning approach in which, beyond the typical goal of predicting the behavior of interest, the predictor also incorporates a second compulsory goal that enforces chance performance in the control task. Together, these findings provide a firmer scientific foundation for understanding the neural basis of a neglected class of behavior, and they suggest an approach for improving validity of neural predictors.