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作者：White, Robin R.; Hall, Mary Beth
作者单位：Virginia Polytechnic Institute & State University; United States Department of Agriculture (USDA)
摘要：Reduced consumption of animal- sourced food (ASF) has been recommended for environmental and human health objectives; however, ASF can be important for food security and diet affordability. We explored country- level relationships among various metrics of food supply, socioeconomic context, food security, diet affordability, and agricultural greenhouse gas emissions (GHGe) to characterize how optimal inclusion ranges for ASF vary with socioeconomic factors and food system goals. Data from 2015...
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作者：Xu, Xufeng; Rebane, Aleksander A.; Julia, Laura Roset; Rosowski, Kathryn A.; Dufresne, Eric R.; Stellacci, Francesco
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; ETH Zurich; New York University; New York University Abu Dhabi; Cornell University; Cornell University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：Liquid-liquid phase separation (LLPS) is an intracellular process widely used by cells for many key biological functions. It occurs in complex and crowded environments, where amino acids (AAs) are vital components. We have found that AAs render the net interaction between proteins more repulsive. Here, we find that some AAs efficiently suppress LLPS in test tubes (in vitro). We then screen all the proteinogenic AAs and find that three specific AAs, including proline, glutamine, and glycine, si...
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作者：Maldonado, Bryan O. Torres; Tao, Ran; Brosseau, Quentin; Mathijssen, Arnold J. T. M.; Arratia, Paulo E.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Many microorganisms exhibit upstream swimming, which is important to many biological processes and can cause contamination of biomedical devices and the infection of organs. This process, called rheotaxis, has been studied extensively in Newtonian fluids. However, most microorganisms thrive in non-Newtonian fluids that contain suspended polymers such as mucus and biofilms. Here, we investigate the rheotactic behavior of Escherichia coli near walls in non-Newtonian fluids. Our experiments demon...
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作者：Matsuzaki, Takahisa; Fujii, Mai; Noro, Hayata; Togo, Shodai; Watanabe, Mami; Suganuma, Masami; Sharma, Shivani; Kobayashi, Naritaka; Kawamura, Ryuzo; Nakabayashi, Seiichiro; Yoshikawa, Hiroshi Y.
作者单位：University of Osaka; University of Osaka; Saitama University; Saitama University; National Science Foundation (NSF); NSF - Directorate for Engineering (ENG)
摘要：We developed an advanced optical microscope for the simultaneous visualization of membrane fluidity and morphology to define cell adhesion signatures. This microscope combines ratiometric spectral imaging of membrane fluidity and interferometric imaging of membrane morphology. As a preliminary demonstration, we simultaneously visualized the interface between a giant unilamellar vesicle (GUV) and a glass substrate at different temperatures. We identified more fluid regions of the membrane and m...
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作者：Zhai, Guijin; Niu, Ziping; Jiang, Zixin; Zhao, Fei; Wang, Siyu; Chen, Chen; Zheng, Wei; Wang, Aiyuan; Zang, Yong; Han, Yanpu; Zhang, Kai
作者单位：Tianjin Medical University; Shandong Laboratory of Yantai Drug Discovery; Tianjin Medical University; Tianjin Medical University; Tianjin Medical University; Tianjin Medical University
摘要：Lysine lactylation (Kla) is a new type of histone mark implicated in the regulation of various functional processes such as transcription. However, how this histone mark acts in cancers remains unexplored due in part to a lack of knowledge about its reader proteins. Here, we observe that cervical cancer (CC) cells undergo metabolic reprogram by which lactate accumulation and thereby boosts histone lactylation, particularly H3K14la. Utilizing a multivalent photoaffinity probe in combination wit...
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作者：Chen, Jingying; Wang, Ting; Zhang, Dongzhe; Wang, Huiling; Huang, Zhiang; Yang, Zhongxin; Li, Jizhuo; Hu, Tianyi; Wang, Xin; Li, Xia
作者单位：Henan University; Henan University; Henan University
摘要：The p38 MAP kinase (MAPK) signaling pathway plays pivotal roles in various cellular processes. Phosphorylation serves as a canonical way to regulate p38 alpha activation through a phosphorylation cascade. Thus, understanding the mechanism governing p38 alpha phosphorylation is important. The present study demonstrated that p38 alpha undergoes methylation at K165, which promote its phosphorylation in tumor cells. Inhibition of p38 alpha methylation impairs p38 alpha phosphorylation, repressing ...
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作者：Jeon, Hyungju; Kim, Jiwon; Kim, Jayoung; Choi, Yoon Kyoung; Ho, Chun Lum Andy; Pifferi, Fabien; Huber, Daniel; Feng, Linqing; Kim, Jinhyun
作者单位：Korea Institute of Science & Technology (KIST); Korea University; University of Geneva; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Museum National d'Histoire Naturelle (MNHN); Sungkyunkwan University (SKKU); Korea Institute of Science & Technology (KIST)
摘要：The gray mouse lemur ( Microcebus murinus), one of the smallest living primates, emerges as a promising model organism for neuroscience research. This is due to its genetic similarity to humans, its evolutionary position between rodents and humans, and its primate- like features encapsulated within a rodent- sized brain. Despite its potential, the absence of a comprehensive reference brain atlas impedes the progress of research endeavors in this species, particularly at the microscopic level. ...
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作者：Liu, Yizhou; Hu, Jiliang; Gore, Jeff
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：The stability of ecological communities has a profound impact on humans, ranging from individual health influenced by the microbiome to ecosystem services provided by fisheries. A long- standing goal of ecology is the elucidation of the interplay between biodiversity and ecosystem stability, with some ecologists warning of instability due to loss of species diversity while others arguing that greater diversity will instead lead to instability. Here, by considering a minimal two- level ecosyste...
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作者：Wang, Hanlin; Tarsio, Maureen; Kane, Patricia M.; Rubinstein, John L.
作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; State University of New York (SUNY) System; SUNY Upstate Medical University; University of Toronto
摘要：Vacuolar-type ATPases (V- ATPases) are membrane- embedded proton pumps that acidify intracellular compartments in almost all eukaryotic cells. Homologous with ATP synthases, these multisubunit enzymes consist of a soluble catalytic V1 subcomplex and a membrane- embedded proton- translocating VO subcomplex. The V1 and VO subcomplexes can undergo reversible dissociation to regulate proton pumping, with reassociation of V1 and VO requiring the protein complex known as RAVE (regulator of the ATPas...
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作者：Glaubitz, Alina; Fu, Feng
作者单位：Dartmouth College; Dartmouth College
摘要：In fighting infectious diseases posing a global health threat, ranging from influenza to Zika, nonpharmaceutical interventions (NPI), such as social distancing and face covering, remain mitigation measures public health can resort to. However, the success of NPI lies in sufficiently high levels of collective compliance, otherwise giving rise to recurrent infections that are not only driven by pathogen evolution but also changing vigilance in the population. Here, we show that compliance with e...
