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作者：Iordana, Coraline Rinn; Ritvo, Victoria J. H.; Norman, Kenneth A.; Turk-Browne, Nicholas B.; Cohen, Jonathan D.
作者单位：University of Rochester; University of Rochester; Princeton University; Yale University
摘要：Learning requires changing the brain. This typically occurs through experience, study, or instruction. We report an alternate route for humans to acquire visual knowledge, through the direct sculpting of activity patterns in the human brain that mirror those expected to arise through learning. We used neurofeedback from closed- loop real- time functional MRI to create new categories of visual objects in the brain, without the participants' explicit awareness. After neural sculpting, participan...
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作者：Hsieh, Annie L.; Ganesh, Sanika; Kula, Tomasz; Irshad, Madiha; Ferenczi, Emily A.; Wang, Wengang; Chen, Yi - Ching; Hu, Song - Hua; Li, Zongyu; Joshi, Shakchhi; Haigis, Marcia C.; Sabatini, Bernardo L.
作者单位：Howard Hughes Medical Institute; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School
摘要：Gliomas are the most common malignant primary brain tumor and are often associated with severe neurological deficits and mortality. Unlike many cancers, gliomas rarely metastasize outside the brain, indicating a possible dependency on unique features of brain microenvironment. Synapses between neurons and glioma cells exist, suggesting that glioma cells rely on neuronal inputs and synaptic signaling for proliferation. Yet, the locations and properties of neurons that innervate gliomas have rem...
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作者：Morin, Chloe; Baudin-Baillieu, Agnes; Van Long, Flora Nguyen; Isaac, Caroline; Bidou, Laure; Arbes, Hugo; Francois, Pauline; Pommier, Roxane M.; Adrait, Annie; Saku, Akari; Gran, Stephanie; Machkouri, Camelia; Vanbelle, Christophe; Morichon, Romain; Boissan, Mathieu; Catez, Frederic; Ferrari, Anthony; Morel, Anne-Pierre; Coute, Yohann; Chat, Sophie; Giudice, Emmanuel; Gillet, Reynald; Puisieux, Alain; Moyret-balle, Caroline; Diaz, Jean- Jacques; Namy, Olivier; Marcel, Virginie
作者单位：Centre National de la Recherche Scientifique (CNRS); UNICANCER; Centre Leon Berard; Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Claude Bernard Lyon 1; UNICANCER; Centre Leon Berard; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CEA; UNICANCER; Centre Leon Berard; Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Hopital Universitaire Charles-Foix - APHP; UNICANCER; Centre Leon Berard; Universite de Rennes; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); UNICANCER; Universite PSL; Institut Curie; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC)
摘要：Epithelial-mesenchymal transition (EMT) involves profound changes in cell morphology, driven by transcriptional and epigenetic reprogramming. However, evidence suggests that translation and ribosome composition also play key roles in establishing pathophysiological phenotypes. Using genome-wide analyses, we reported significant rearrangement of the translational landscape and machinery during EMT. Specifically, a cell line overexpressing the EMT transcription factor ZEB1 displayed alterations ...
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作者：Peng, Kang; Jiang, Chenxiao; Zhang, Zirui; Zhang, Chao; Wang, Jing; Song, Wanjie; Ma, Yunxin; Tang, Gonggen; Zuo, Peipei; Yang, Zhengjin; Xu, Tongwen
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：Aqueous organic redox flow batteries (AORFBs), which exploit the reversible redox reactions of water- soluble organic electrolytes to store electricity, have emerged as a promising electrochemical energy storage technology. Organic electrolytes possess fast electron- transfer rates that are two or three orders of magnitude faster than those of their inorganic or organometallic counterparts; therefore, their performance at the electrode is limited by mass transport. Direct adoption of conventio...
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作者：Porter, Zach; Shen, Lingjia; Plumley, Rajan; Burdet, Nicolas G.; Petsch, Alexander N.; Wen, Jiajia; Drucker, Nathan C.; Peng, Cheng; Chen, Xiaoqian M.; Fluerasu, Andrei; Blackburn, Elizabeth; Coslovich, Giacomo; Hawthorn, David G.; Turner, Joshua J.
作者单位：Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Carnegie Mellon University; Massachusetts Institute of Technology (MIT); Harvard University; United States Department of Energy (DOE); Brookhaven National Laboratory; Lund University; University of Waterloo
摘要：In unconventional superconductors, coupled charge and lattice degrees of freedom can manifest in ordered phases of matter that are intertwined. In the cuprate family, fluctuating short-range charge correlations can coalesce into a longer-range charge density wave (CDW) order which is thought to intertwine with superconductivity, yet the nature of the interaction is still poorly understood. Here, by measuring subtle of seconds) through X-ray photon correlation spectroscopy, we report sensitivit...
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作者：Kan, Anthony S. H.; Kusay, Ali S.; Mohammadi, Nazanin A.; Lin, Susan X. N.; Liao, Vivian W. Y.; Lesca, Gaetan; Souci, Sabrine; Milh, Mathieu; Christophersen, Palle; Chebib, Mary; Moller, Rikke S.; Absalom, Nathan L.; Jensen, Anders A.; Ahring, Philip K.
作者单位：University of Sydney; Linkoping University; University of Southern Denmark; CHU Lyon; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Claude Bernard Lyon 1; CHU Lyon; Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Western Sydney University; University of Copenhagen
摘要：Recent discoveries have revealed that genetic variants in gamma- aminobutyric acid type A (GABAA) receptor subunits can lead to both gain- of- function (GOF) and loss- of- function (LOF) receptors. GABAA receptors, however, have a pseudosymmetrical pentameric assembly, and curiously diverse functional outcomes have been reported for certain homologous variants in paralogous genes (paralogous variants). To investigate this, we assembled a cohort of 11 individuals harboring paralogous M1 proline...
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作者：Nguyen, Hung N.; Jeong, Yunju; Kim, Yunhye; Kamiya, Mari; Kim, Yaunghyun; Athar, Humra; Castaldi, Peter J.; Hersh, Craig P.; Menon, Jaivardhan A.; Wong, Jessie; Chan, Ian; Oldham, William M.; Padera, Robert F.; Sharma, Nirmal S.; Sholl, Lynette M.; Vivero, Marina; Watts, Gerald F. M.; Knipe, Rachel S.; Black, Katharine E.; Hariri, Lida P.; Yun, Jeong H.; Merriam, Louis T.; Yuan, Ke; Kim, Edy Y.; Brenner, Michael B.
作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Kyung Hee University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：Fibrosis drives end- organ damage in many diseases. However, clinical trials targeting individual upstream activators of fibroblasts, such as TGF(3, have largely failed. Here, we target the leukemia inhibitory factor receptor (LIFR) as an autocrine master amplifier of multiple upstream activators of lung fibroblasts. In idiopathic pulmonary fibrosis (IPF), the most common fibrotic lung disease, we found that lung myofibroblasts had high LIF expression, and the fibroblasts in fibroblastic foci ...
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作者：Di Marco, N.; Loru, Edoardo; Bonetti, Anita; Serra, Alessandra Olga Grazia; Cinelli, Matteo; Quattrociocchi, Walter; Fiske, Susan
作者单位：Sapienza University Rome; Sapienza University Rome; Tuscia University
摘要：Understanding the impact of digital platforms on user behavior presents foundational challenges, including issues related to polarization, misinformation dynamics, and variation in news consumption. Comparative analyses across platforms and over different years can provide critical insights into these phenomena. This study investigates the linguistic characteristics of user comments over 34 y, focusing on their complexity and temporal shifts. Using a dataset of approximately 300 million Englis...
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作者：Zhang, Xueqing; Li, Zhe; Sun, Wei; Zhang, Yuhua; Li, Jinlin; Wang, Li
作者单位：South Central Minzu University
摘要：Fischer-Tropsch synthesis represents a key endeavor aimed at converting nonpetroleum carbon resources into clean fuels and valuable chemicals. However, the current state-of-the-art industrial FTS employing Fe-based catalysts is still challenged by the low carbon efficiency (<50%), mainly attributed to the prominent formation of CO2 and CH4 resulting from the nonregulated side water gas shift reaction. Herein, we describe a shielding strategy involving the encapsulation of the active H & auml;g...
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作者：Chen, Michael A.; Lee, Sang Hyun; Kang, Peter K.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
摘要：Solute transport and biogeochemical reactions in porous and fractured media flows are controlled by mixing, as are subsurface engineering operations such as contaminant remediation, geothermal energy production, and carbon sequestration. Porous media flows are generally regarded as slow, so the effects of fluid inertia on mixing and reaction are typically ignored. Here, we demonstrate through microfluidic experiments and numerical simulations of mixing- induced reaction that inertial recircula...
