50期

最新文章

• Very broad distribution of β sheet registries of the HIV gp41 fusion peptide supports mutational robustness for fusion and infection AI翻译
  作者：Zhang, Yijin; Schmick, Scott D.; Xie, Li; Ghosh, Ujjayini; Weliky, David P.
  作者单位：Wuhan University of Science & Technology; 3M; St Jude Children's Research Hospital; Michigan State University
  摘要：HIV, like other membrane-enveloped viruses, has protein spikes that include a fusion peptide (Fp) segment that binds the host cell membrane and plays a critical role in fusion (joining) viral and cell membranes. The HIV Fp is the similar to 23 N-terminal residues of the gp41 spike protein. Fp adopts intermolecular antiparallel beta sheet structure when lipid fraction cholesterol approximate to 0.3, which is comparable to host cells. Rotational-echo double-resonance NMR was applied to probe the...
• One Health needs ecology AI翻译
  作者：Gittleman, John L.
  作者单位：University System of Georgia; University of Georgia; Duke University
• TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in the mammalian brain AI翻译
  作者：Matsushita, Yumi; Yoshida, Kaede; Yoshiya, Miyuki; Shimizu, Takahiro; Tsukamoto, Satoshi; Kudo, Nobuki; Takeuchi, Yuichi; Higuchi, Makoto; Shimojo, Masafumi
  作者单位：National Institutes for Quantum Science & Technology; Hokkaido University; National Institutes for Quantum Science & Technology; Hokkaido University; Kindai University (Kinki University)
  摘要：Ultrasound neuromodulation has become an innovative technology that enables noninvasive intervention in mammalian brain circuits with high spatiotemporal precision. Despite the expanding utility of ultrasound neuromodulation in the neuroscience research field and clinical applications, the molecular and cellular mechanisms by which ultrasound impacts neural activity in the brain are still largely unknown. Here, we report that transient receptor potential canonical 6 (TRPC6), a mechanosensitive...
• An integrated picture of the structural pathways controlling the heart performance AI翻译
  作者：Morotti, Ilaria; Caremani, Marco; Marcello, Matteo; Pertici, Irene; Squarci, Caterina; Bianco, Pasquale; Narayanan, Theyencheri; Piazzesi, Gabriella; Reconditi, Massimo; Lombardi, Vincenzo; Linari, Marco
  作者单位：University of Florence; University of Florence; European Synchrotron Radiation Facility (ESRF); University of Florence
  摘要：The regulation of heart function is attributed to a dual filament mechanism: i) the Ca2+-dependent structural changes in the regulatory proteins of the thin, actin-containing filament making actin available for myosin motor attachment, and ii) the release of motors from their folded (OFF) state on the surface of the thick filament allowing them to attach and pull the actin filament. Thick filament mechanosensing is thought to control the number of motors switching ON in relation to the systoli...
• Prenatal social disadvantage is associated with alterations in functional networks at birth AI翻译
  作者：Nielsen, Ashley N.; Triplett, Regina L.; Bernardez, Lourdes M.; Tooley, Ursula A.; Herzberg, Max P.; Lean, Rachel E.; Kaplan, Sydney; Meyer, Dominique; Kenley, Jeanette K.; Alexopoulos, Dimitrios; Losielle, David; Latham, Aidan; Smyser, Tara A.; Agrawal, Arpana; Shimony, Josh S.; Jackson, Joshua J.; Miller, J. Philip; Raichle, Marcus E.; Warner, Barbara B.; Rogers, Cynthia E.; Sylvester, Chad M.; Barch, Deanna M.; Luby, Joan L.; Smyser, Christopher D.
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
  摘要：Childhood exposure to social disadvantage is a major risk factor for psychiatric disorders and poor developmental, educational, and occupational outcomes, presumably because adverse exposures alter the neurodevelopmental processes that contribute to risk trajectories. Yet, given the limited social mobility in the United States and other countries, childhood social disadvantage is frequently preceded by maternal social disadvantage during pregnancy, potentially altering fetal brain development ...
• Proteomic characterization of a foraminiferal test's organic matrix AI翻译
  作者：Prada, Fiorella; Haramaty, Liti; Livnah, Oded; Shaul, Racheli; Abramovich, Sigal; Mass, Tali; Rosenthal, Yair; Falkowski, Paul G.
  作者单位：Rutgers University System; Rutgers University New Brunswick; Hebrew University of Jerusalem; Ben-Gurion University of the Negev; University of Haifa; Rutgers University System; Rutgers University New Brunswick
  摘要：Foraminifera are unicellular protists capable of precipitating calcite tests, which fossilize and preserve geochemical signatures of past environmental conditions dating back to the Cambrian period. The biomineralization mechanisms responsible for the mineral structures, which are key to interpreting palaeoceanographic signals, are poorly understood. Here, we present an extensive analysis of the test- bound proteins. Using liquid chromatography-tandem mass spectrometry, we identify 373 test- b...
• On the control of cell proliferation AI翻译
  作者：Thirumalai, D.; Das, Rajsekhar; Li, Xin
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
• OmpA controls order in the outer membrane and shares the mechanical load AI翻译
  作者：Benn, Georgina; Borrelli, Carolina; Prakaash, Dheeraj; Johnson, Alex N. T.; Fideli, Vincent A.; Starr, Tahj; Fitzmaurice, Dylan; Combs, Ashton N.; Wuehr, Martin; Rojas, Enrique R.; Khalid, Syma; Hoogenboom, Bart W.; Silhavy, Thomas J.
  作者单位：Princeton University; University of London; University College London; University of London; University College London; Imperial College London; University of Oxford; Princeton University; Princeton University; University of London; University College London; New York University
  摘要：OmpA, a predominant outer membrane (OM) protein in Escherichia coli, affects virulence, adhesion, and bacterial OM integrity. However, despite more than 50 y of research, the molecular basis for the role of OmpA has remained elusive. In this study, we demonstrate that OmpA organizes the OM protein lattice and mechanically connects it to the cell wall (CW). Using gene fusions, atomic force microscopy, simulations, and microfluidics, we show that the beta- barrel domain of OmpA is critical for m...
• Density amplifiers of cooperation for spatial games AI翻译
  作者：Svoboda, Jakub; Chatterjee, Krishnendu
  作者单位：Institute of Science & Technology - Austria
  摘要：Spatial games provide a simple and elegant mathematical model to study the evolution of cooperation in networks. In spatial games, individuals reside in vertices, adopt simple strategies, and interact with neighbors to receive a payoff. Depending on their own and neighbors' payoffs, individuals can change their strategy. The payoff is determined by the Prisoners' Dilemma, a classical matrix game, where players cooperate or defect. While cooperation is the desired behavior, defection provides a...
• Caspase-8-dependent autophagy regulates neutrophil infiltration in oral squamous cell carcinoma AI翻译
  作者：Bernabe, Miguel; Watt, Fiona M.
  作者单位：University of London; King's College London; European Molecular Biology Laboratory (EMBL)
  摘要：Oral squamous cell carcinoma (OSCC) is a subtype of head and neck cancer that arises in the multilayered epithelia of the mouth and lips. Although inactivating mutations in CASP8 are frequently found in human OSCC their role in the disease is unknown. To investigate this, we deleted Casp8 in the oral epithelium of adult mice. Loss of Caspase- 8 resulted in defects in the tongue epithelial barrier and triggered a neutrophil- rich immune infiltrate distinct from that observed on epidermal Casp8 ...