2024

最新文章

• Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer AI翻译
  作者：Han, Xinlu; Wang, Deyu; Yang, Liao; Wang, Ning; Shen, Jianliang; Wang, Jinghan; Zhang, Lei; Chen, Li; Gao, Shenglan; Zong, Wei-Xing; Wang, Yongbo
  作者单位：Fudan University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Rutgers University System; Rutgers University New Brunswick; Fudan University; Fudan University; Fudan University; Fudan University; Fudan University
  摘要：Polyamines are a class of small polycationic alkylamines that play essential roles in both normal and cancer cell growth. Polyamine metabolism is frequently dysregulated and considered a therapeutic target in cancer. However, targeting polyamine metabolism as monotherapy often exhibits limited efficacy, and the underlying mechanisms are incompletely understood. Here we report that activation of polyamine catabolism promotes glutamine metabolism, leading to a targetable vulnerability in lung ca...
• Integration of photothermal water evaporation with photocatalytic microplastics upcycling via nanofluidic thermal management AI翻译
  作者：Meng, Xiangyu; Wang, Xin; Yin, Kuibo; Jing, Yao; Gu, Liuning; Tao, Zequan; Ren, Xinchuan; Tang, Mingyu; Shao, Xinxing; Sun, Litao; Sun, Yueming; Dai, Yunqian; Xiong, Yujie
  作者单位：Southeast University - China; Anhui Normal University; Southeast University - China; Southeast University - China; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：Photothermal heating and photocatalytic treatment are two solar- driven water processing approaches by harnessing NIR and UV-vis light, respectively, which can fully utilize solar energy if integrated. However, it remains a challenge to achieve high performance in both approaches when integrated in a material due to uncontrollable heat diffusion. Here, we report a demonstration of heat confinement on photothermal sites and fluid cooling on photocatalysis sites at the nanoscale, within a well- ...
• Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7 AI翻译
  作者：Borettoa, Matteo; Geurtsa, Maarten H.; Gandhia, Shashank; Mac, Zilian; Staliarovae, Nadzeya; Celottia, Martina; Lima, Sangho; Hea, Gui-Wei; Millena, Rosemary; Driehuisa, Else; Begthela, Harry; Smabersf, Lidwien; Roodhartf, Jeanine; van Esa, Johan; Wu, Wei; Clevers, Hans
  作者单位：Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center; University of California System; University of California Berkeley; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); National University of Singapore; Utrecht University; Utrecht University; Utrecht University; Utrecht University Medical Center; Roche Holding
  摘要：FBXW7 is an E3 ubiquitin ligase that targets proteins for proteasome- mediated degradation and is mutated in various cancer types. Here, we use CRISPR base editors to introduce different FBXW7hotspot mutations in human colon organoids. Functionally, FBXW7 mutation reduces EGF dependency of organoid growth by similar to 10,000-fold. Combined transcriptomic and proteomic analyses revealed increased EGFR protein stability in FBXW7 mutants. Two distinct phosphodegron motifs reside in the cytoplasm...
• Thermodynamic modulation of gephyrin condensation by inhibitory synapse components AI翻译
  作者：Lee, Gyehyun; Kim, Seungjoon; Hwangd, Da-Eun; Eomd, Yu-Gon; Jang, Gyubin; Park, Hye Yoon; Choi, Jeong-Mo; Ko, Jaewon; Shin, Yongdae
  作者单位：Seoul National University (SNU); Daegu Gyeongbuk Institute of Science & Technology (DGIST); Daegu Gyeongbuk Institute of Science & Technology (DGIST); Pusan National University; Seoul National University (SNU); University of Minnesota System; University of Minnesota Twin Cities; Seoul National University (SNU)
  摘要：Phase separation drives compartmentalization of intracellular contents into various biomolecular condensates. Individual condensate components are thought to differentially contribute to the organization and function of condensates. However, how intermolecular interactions among constituent biomolecules modulate the phase behaviors of multicomponent condensates remains unclear. Here, we used core components of the inhibitory postsynaptic density (iPSD) as a model system to quantitatively probe...
• Harmonizing the cyano- group and Na to enhance selective photocatalytic O2 activation on carbon nitride for refractory pollutant degradation AI翻译
  作者：Xu, Mingkai; Wang, Ruizhao; Fu, Haoyang; Shi, Yanbiao; Ling, Lan
  作者单位：Tongji University; Shanghai Jiao Tong University
  摘要：Manipulating exciton dissociation and charge- carrier transfer processes to selectively generate free radicals of more robust photocatalytic oxidation capacity for mineralizing refractory pollutants remains challenging. Herein, we propose a strategy by simultane-ously introducing the cyano- group and Na into graphitic carbon nitride (CN) to obtain CN- Cy- Na, which makes the charge- carrier transfer pathways the dominant process and consequently achieves the selective generation of free radica...
• Generation of human excitatory forebrain neurons by cooperative binding of proneural NGN2 and homeobox factor EMX1 AI翻译
  作者：Ang, Cheen Euong; Olmos, Victor Hipolito; Vodehnal, Kayla; Zhou, Bo; Lee, Qian Yi; Sinha, Rahul; Narayanaswamy, Aadit; Mall, Moritz; Chesnov, Kirill; Dominicus, Caia S.; Suedhof, Thomas; Wernig, Marius
  作者单位：Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Central Institute of Mental Health; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Wellcome Trust Sanger Institute
  摘要：Generation of defined neuronal subtypes from human pluripotent stem cells remains a challenge. The proneural factor NGN2 has been shown to overcome experimental variability observed by morphogen- guided differentiation and directly converts pluripotent stem cells into neurons, but their cellular heterogeneity has not been investigated yet. Here, we found that NGN2 reproducibly produces three different kinds of excitatory neurons characterized by partial coactivation of other neurotransmitter p...
• Metabolomes evolve faster than metabolic network structures AI翻译
  作者：Chen, Yu; Li, Feiran
  作者单位：Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Tsinghua University; Tsinghua Shenzhen International Graduate School
• Central tolerance shapes the neutralizing B cell repertoire against a persisting virus in its natural host AI翻译
  作者：Florova, Marianna; Mota, Tiago Abreu -; Paesen, Guido C.; Beetschen, Anna Sophia; Cornille, Karen; Marx, Anna-Friederike; Narr, Kerstin; Sahin, Mehmet; Dimitrova, Mirela; Swarnalekha, Nivedya; Wagner, Jane Beil -; Savic, Natasa; Pelczar, Pawel; Buch, Thorsten; King, Carolyn G.; Bowden, Thomas A.; Pinschewer, Daniel D.
  作者单位：University of Basel; University of Oxford; Wellcome Centre for Human Genetics; University of Basel; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Basel; Helmholtz Association; Max Delbruck Center for Molecular Medicine
  摘要：Viral mimicry of host cell structures has been postulated to curtail the B cell receptor (BCR) repertoire against persisting viruses through tolerance mechanisms. This concept awaits, however, experimental testing in a setting of natural virus-host relationship. We engineered mouse models expressing a monoclonal BCR specific for the envelope glycoprotein of lymphocytic choriomeningitis virus (LCMV), a naturally persisting mouse pathogen. When the heavy chain of the LCMV- neutralizing antibody ...
• Human paraneoplastic antigen Ma2 (PNMA2) forms icosahedral capsids that can be engineered for mRNA delivery AI翻译
  作者：Madigan, Victoria; Zhang, Yugang; Raghavan, Rumya; Wilkinson, Max E.; Faure, Guilhem; Puccio, Elena; Segel, Michael; Lash, Blake; Macrae, Rhiannon K.; Zhang, Feng
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute
  摘要：A number of endogenous genes in the human genome encode retroviral gag - like proteins, which were domesticated from ancient retroelements. The paraneoplastic Ma antigen (PNMA) family members encode a gag - like capsid domain, but their ability to assemble as capsids and traffic between cells remains mostly uncharacterized. Here, we systematically investigate human PNMA proteins and find that a number of PNMAs are secreted by human cells. We determine that PNMA2 forms icosahedral capsids effic...
• Unique insights into the design of low- strain single- crystalline Ni- rich cathodes with superior cycling stability AI翻译
  作者：Han, Qiang; Yu, Haifeng; Cai, Lele; Chen, Ling; Li, Chunzhong; Jiang, Hao
  作者单位：East China University of Science & Technology; East China University of Science & Technology
  摘要：Micro- sized single- crystalline Ni- rich cathodes are emerging as prominent candidates owing to their larger compact density and higher safety compared with poly- crystalline counterparts, yet the uneven stress distribution and lattice oxygen loss result in the intragranular crack generation and planar gliding. Herein, taking LiNi0.83Co0.12Mn0.05O2 as an example, an optimal particle size of 3.7 mu m is predicted by simulating the stress distributions at various states of charge and their rela...