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作者：Szalinski, Christina
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作者：Pandey, Abhishek; Ye, Yang; Wells, Chad R.; Singer, Burton H.; Galvani, Alison P.
作者单位：Yale University; State University System of Florida; University of Florida
摘要：population, exacerbating a spectrum of other diseases and contributing significantly to morbidity and mortality overall. Recent advances in pharmaceutical interventions, tirzepatide), have shown remarkable efficacy in weight- loss. However, limited access to these medications due to high costs and insurance coverage issues restricts their utility in mitigating the obesity epidemic. We quantify the annual mortality burden directly attributable to limited access to these medications in the US. B...
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作者：McGuire, Caroline K.; Meehan, Ambryn S.; Couser, Evan; Bull, Lois; Minor, Allegra C.; Hogan, Alexandra Kuhlmann -; Kaech, Susan M.; Shaw, Reuben J.; Eichner, Lillian J.
作者单位：Northwestern University; Salk Institute; Salk Institute
摘要：Histone Deacetylase 3 (HDAC3) function in vivo is nuanced and directed in a tissue- specific fashion. The importance of HDAC3 in Kras mutant lung tumors has recently been identified, but HDAC3 function in this context remains to be fully elucidated. Here, we identified HDAC3 as a lung tumor cell-intrinsic transcriptional regulator of the tumor immune microenvironment. In Kras mutant lung cancer cells, we found that HDAC3 is a direct transcriptional repressor of a cassette of secreted chemokine...
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作者：McKinnon, Karen A.; Simpson, Isla R.; Williams, A. Park
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：Summer temperature extremes can have large impacts on humans and the biosphere, and an increase in heat extremes is one of the most visible symptoms of climate change. Multiple mechanisms have been proposed that would predict faster warming of heat extremes than typical summer days, but it is unclear whether this is occurring. Here, we show that, in both observations and historical climate model simulations, the hottest summer days have warmed at the same pace as the median globally, in each h...
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作者：Sahu, Ratimanasee; Sharma, Mohit; Schall, Peter; Bhattacharyya, Sarika Maitra; Chikkadi, Vijayakumar
作者单位：Indian Institute of Science Education & Research (IISER) Pune; Council of Scientific & Industrial Research (CSIR) - India; CSIR - National Chemical Laboratory (NCL); Academy of Scientific & Innovative Research (AcSIR); University of Amsterdam
摘要：Amorphous solids relax via slow molecular rearrangement induced by thermal fluctuations or applied stress. Microscopic structural signatures predicting these structural relaxations have been long searched for but have so far only been found in dynamic quantities such as vibrational quasi-localized soft modes or with structurally trained neural networks. A physically meaningful structural quantity remains elusive. Here, we introduce a structural order parameter derived from the mean-field cagin...
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作者：Carrico, Adam W.; Ryan, Daniel T.; Berona, Johnny; Dominguez, Benjamin S.; Schrock, Joshua M.; McDade, Thomas W.; Newcomb, Michael; D'Aquila, Richard T.; Mustanski, Brian
作者单位：State University System of Florida; Florida International University; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine
摘要：Methamphetamine use and HIV disproportionately affect sexual and gender minority (SGM) people assigned male at birth. Identifying risk factors for methamphetamine use is crucial to inform preventive interventions. In this cohort study with 1,296 SGM people assigned male at birth, ages 16 to 29, and who resided in Chicago, Poisson regression analyses indicated the prevalence of methamphetamine use increased from 2015 to 2023 [Incidence Rate Ratio (IRR) = 1.07; 95% CI = 1.01 to 1.13; P = 0.02]. ...
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作者：Feng, Li; Gong, Huiying; Zhang, Shen; Liu, Xiang; Wang, Yu; Che, Jincan; Dong, Ang; Griffin, Christopher H.; Gragnoli, Claudia; Wu, Jie; Yau, Shing-Tung; Wu, Rongling
作者单位：Chinese Academy of Fishery Sciences; Fishery Engineering Research Institute, CAFS; Beijing Forestry University; Tsinghua University; Nankai University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Creighton University; Tsinghua University
摘要：Interactions among the underlying agents of a complex system are not only limited to dyads but can also occur in larger groups. Currently, no generic model has been developed to capture high- order interactions (HOI), which, along with pairwise interactions, portray a detailed landscape of complex systems. Here, we integrate evolutionary game theory and behavioral ecology into a unified statistical mechanics framework, allowing all agents (modeled as nodes) and their bidirectional, signed, and...
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作者：Levin, Ido; Sadaba, Naroa; Nelson, Alshakim; Keller, Sarah L.
作者单位：University of Washington; University of Washington Seattle
摘要：Unlike human intestines, which are long, hollow tubes, the intestines of sharks and rays contain interior helical structures surrounding a cylindrical hole. One function of these structures may be to create asymmetric flow, favoring passage of fluid down the digestive tract, from anterior to posterior. Here, we design and 3D print biomimetic models of shark intestines, in both rigid and deformable materials. We use the rigid models to test which physical parameters of the interior helices (the...
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作者：Regnard, Sarah; Otani, Masahiko; Keruzore, Marc; Teinturier, Alizee; Blondel, Marc; Kawakami, Naoto; Krapp, Anne; Colcombet, Jean
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universite Paris Cite; INRAE; Meiji University; CHU Brest; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Bretagne Occidentale; INRAE; Universite Paris Saclay; AgroParisTech
摘要：Seed dormancy corresponds to a reversible blockage of germination. Primary dormancy is established during seed maturation, while secondary dormancy is set up on the dispersed seed, following an exposure to unfavorable factors. Both dormancies are relieved in response to environmental factors, such as light, nitrate, and coldness. Quantitive Trait Locus (QTL) analyses for preharvest sprouting identified MKK3 kinase in cereals as a player in dormancy control. Here, we showed that MKK3 also plays...
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作者：Shaheen, Basamat S.; Huynh, Kenny; Quan, Yujie; Choudhry, Usama; Gnabasik, Ryan; Xiang, Zeyu; Goorsky, Mark; Liao, Bolin
作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Los Angeles
摘要：Semiconductor heterojunctions have gained significant attention for efficient optoelectronic devices owing to their unique interfaces and synergistic effects. Interaction between charge carriers with the heterojunction plays a crucial role in determining device performance, while its spatial-temporal mapping remains lacking. In this study, we employ scanning ultrafast electron microscopy (SUEM), an emerging technique that combines high spatial-temporal resolution and surface sensitivity, to in...
