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作者：Ravindran, Sandeep
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作者：Shan, Liying; Wang, Wenmeng; Du, Lijuan; Li, Dangdang; Wang, Yunxuan; Xie, Yuyan; Li, Hongyan; Wang, Jiale; Shi, Zhihao; Zhou, Yang; Zhu, Daling; Sui, Guangchao; Liu, Fang
作者单位：Harbin Medical University; Northeast Forestry University - China; Harbin Medical University
摘要：Lung adenocarcinoma (LUAD) is the leading cause of cancer- related death worldwide, but the underlying molecular mechanisms remain largely unclear. The transcription factor (TF) specificity protein 1 (SP1) plays a crucial role in the development of various cancers, including LUAD. Recent studies have indicated that master TFs may form phase- separated macromolecular condensates to promote super- enhancer (SE) assembly and oncogene expression. In this study, we demonstrated that SP1 undergoes p...
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作者：Azbazdar, Yagmur; De Robertis, Edward M.
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：Xenopus embryos provide a favorable material to dissect the sequential steps that lead to dorsal-ventral (D- V) and anterior-posterior (A- P) cell differentiation. Here, we analyze the signaling pathways involved in this process using loss- of- function and gain- of- function approaches. The initial step was provided by Hwa, a transmembrane protein that robustly activates early beta- catenin signaling when microinjected into the ventral side of the embryo leading to complete twinned axes. The ...
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作者：Dou, Xiaoyi; Chen, Kangkang; Brown, Mark R.; Strand, Michael R.
作者单位：University System of Georgia; University of Georgia
摘要：Female mosquitoes produce eggs in gonadotrophic cycles that are divided between a previtellogenic and vitellogenic phase. Previtellogenic females consume water and sugar sources like nectar while also being attracted to hosts for blood feeding. Consumption of a blood meal activates the vitellogenic phase, which produces mature eggs and suppresses host attraction. In this study, we tested the hypothesis that neuropeptide Y- like hormones differentially modulate host attraction behavior in the m...
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作者：Jinushi, Masahisa; Vanneman, Matthew; Munshi, Nikhil C.; Tai, Yu- Tzu; Prabhala, Rao H.; Ritz, Jerome; Neuberg, Donna; Anderson, Kenneth C.; Carrasco, Daniel Ruben; Dranoff, Glenn
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作者：Lara-Saez, Irene; Mencia, Angeles; Recuero, Enrique; Li, Yinghao; Garcia, Marta; Oteo, Marta; Gallego, Marta I.; Enguita, Ana Belen; de Prado-Verdun, Diana; Sigen, A.; Wang, Wenxin; Garcia-Escuderob, Ramon; Murillas, Rodolfo; Santos, Mirentxu
作者单位：University College Dublin; Centro de Investigaciones Energeticas, Medioambientales Tecnologicas; CIBER - Centro de Investigacion Biomedica en Red; CIBERER; Fundacion Jimenez Diaz; Universidad Carlos III de Madrid; Centro de Investigaciones Energeticas, Medioambientales Tecnologicas; Instituto de Salud Carlos III; Hospital Universitario 12 de Octubre; Anhui University of Science & Technology; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC
摘要：Functional analysis in mouse models is necessary to establish the involvement of a set of genetic variations in tumor development. A modeling platform to facilitate and cost- effectively analyze the role of multiple genes in carcinogenesis would be valuable. Here, we present an innovative strategy for lung mutagenesis using CRISPR/Cas9 ribonucleoproteins delivered via cationic polymers. This approach allows the simultaneous inactivation of multiple genes. We validate the effectiveness of this ...
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作者：Liu, Mengmeng; Waduge, Rajitha-Udakara-Sampath Hemba-; Li, Xiao; Huang, Xiahe; Liu, Tzu- Hao; Han, Xianlin; Wang, Yingchun; Ji, Jun- Yuan
作者单位：Tulane University; Princeton University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; University of Texas System; University of Texas at San Antonio
摘要：The Wnt/Wingless signaling pathway plays critical roles in metazoan development and energy metabolism, but its role in regulating lipid homeostasis remains not fully understood. Here, we report that the activation of canonical Wnt/Wg signaling promotes lipolysis while concurrently inhibiting lipogenesis and fatty acid (3- oxidation in both larval and adult adipocytes, as well as cultured S2R+ cells, in Drosophila . Using RNA- sequencing and CUT&RUN (Cleavage Under Targets & Release Using Nucle...
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作者：Lowman, Heili E.; Desiervo, Melissa; Hall Jr, Robert O.; Jahner, Joshua P.; Jimoh, Saheed O.; Laughlin, Daniel C.; Patterson, Amy C.; Weiss-Lehman, Christopher; Barbosa, Carolina C.; Bell, Katherine L.; Blaszczak, Joanna R.; Buerkle, C. Alex; Carter, Alice M.; Collins, Sarah M.; Deleo, Victoria; Dunkle, Matt; Gannon, Dustin; Grames, Eliza M.; Harrison, Joshua G.; McFarlane, S. Eryn; Oleksy, Isabella; Powers, Breanna F.; Ray, Courtenay; Stears, Alice; Summers, Betsy; Torrens, Christa L.; Trentman, Matt; Werner, Chhaya M.; Shoemaker, Lauren G.
作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; University of Wyoming; Union College; University of Montana System; University of Montana; University of Wyoming; Colorado State University System; Colorado State University Fort Collins; Nevada System of Higher Education (NSHE); University of Nevada Reno; Oregon State University; State University of New York (SUNY) System; Binghamton University, SUNY; York University - Canada; University of Colorado System; University of Colorado Boulder; Northern Arizona University; Northern Arizona University; University of Montana System; University of Montana
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作者：Zaidi, Samir; Park, Jooyoung; Chan, Joseph M.; Roudier, Martine P.; Zhao, Jimmy L.; Gopalan, Anuradha; Wadosky, Kristine M.; Patel, Radhika A.; Sayar, Erolcan; Karthaus, Wouter R.; Kates, D. Henry; Chaudhary, Ojasvi; Xu, Tianhao; Masilionis, Ignas; Mazutis, Linas; Chaligne, Ronan; Obradovic, Aleksandar; Linkov, Irina; Barlas, Afsar; Jungbluth, Achim A.; Rekhtman, Natasha; Silber, Joachim; Manova-Todorova, Katia; Watson, Philip A.; True, Lawrence D.; Morrissey, Colm; Scher, Howard I.; Rathkopf, Dana E.; Morris, Michael J.; Goodrich, David W.; Choi, Jungmin; Nelson, Peter S.; Haffner, Michael C.; Sawyers, Charles L.
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Korea University; Korea University Medicine (KU Medicine); Memorial Sloan Kettering Cancer Center; University of Washington; University of Washington Seattle; Memorial Sloan Kettering Cancer Center; Roswell Park Comprehensive Cancer Center; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); Swiss Institute Experimental Cancer Research; NewYork-Presbyterian Hospital; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; University of Washington; University of Washington Seattle; Yale University; Memorial Sloan Kettering Cancer Center; Howard Hughes Medical Institute
摘要：Targeting cell surface molecules using radioligand and antibody- based therapies has yielded considerable success across cancers. However, it remains unclear how the expression of putative lineage markers, particularly cell surface molecules, varies in the process of lineage plasticity, wherein tumor cells alter their identity and acquire new oncogenic properties. A notable example of lineage plasticity is the transformation of prostate adenocarcinoma (PRAD) to neuroendocrine prostate cancer (...
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作者：Bahri, Yasaman; Dyer, Ethan; Kaplan, Jared; Lee, Jaehoon; Sharma, Utkarsh
作者单位：Alphabet Inc.; DeepMind; Johns Hopkins University
摘要：The population loss of trained deep neural networks often follows precise power -law scaling relations with either the size of the training dataset or the number of parameters in the network. We propose a theory that explains the origins of and connects these scaling laws. We identify variance -limited and resolution -limited scaling behavior for both dataset and model size, for a total of four scaling regimes. The variance -limited scaling follows simply from the existence of a well-behaved i...
