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作者：Gillespie, Lauren E.; Ruffley, Megan; Alonso, Moises Exposito -
作者单位：Carnegie Institution for Science; Stanford University; University of California System; University of California Berkeley; Stanford University; Carnegie Institution for Science; Howard Hughes Medical Institute; University of California System; University of California Berkeley
摘要：Anthropogenic habitat destruction and climate change are reshaping the geographic distribution of plants worldwide. However, we are still unable to map species shifts at high spatial, temporal, and taxonomic resolution. Here, we develop a deep learning model trained using remote sensing images from California paired with half a million citizen science observations that can map the distribution of over 2,000 plant species. Our model-Deepbiosphere-not only outperforms many common species distrib...
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作者：Hattori, Shin-ichiro; Bulut, Haydar; Hayashi, Hironori; Kishimoto, Naoki; Takamune, Nobutoki; Hasegawa, Kazuya; Furusawa, Yuri; Yamayoshi, Seiya; Murayama, Kazutaka; Tamamura, Hirokazu; Li, Mi; Wlodawer, Alexander; Kawaoka, Yoshihiro; Misumi, Shogo; Mitsuya, Hiroaki
作者单位：Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Tohoku University; Kumamoto University; Japan Synchrotron Radiation Research Institute; University of Tokyo; Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan; University of Tokyo; Tohoku University; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of Wisconsin System; University of Wisconsin Madison; Kumamoto University
摘要：We generated SARS-CoV-2 variants resistant to three SARS-CoV-2 main protease (Mpro) inhibitors (nirmatrelvir, TKB245, and 5h), by propagating the ancestral SARS- CoV- 2 WK521 WT in VeroE6 TMPRSS2 cells with increasing concentrations of each inhibitor and examined their structural and virologic profiles. A predominant E166V-carrying variant (SARS- CoV- 2 WK521E166V ), which emerged when passaged with nirmatrelvir and TKB245, proved to be resistant to the two inhibitors. A recombinant SARS- CoV-...
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作者：Loy, Conor J.; Servellita, Venice; Sotomayor-Gonzalez, Alicia; Bliss, Andrew; Lenz, Joan S.; Belcher, Emma; Suslovic, Will; Nguyen, Jenny; Williams, Meagan E.; Oseguera, Miriam; Gardiner, Michael A.; Choi, Jong-Ha; Hsiao, Hui-Mien; Wang, Hao; Kim, Jihoon; Shimizu, Chisato; Tremoulet, Adriana H.; Delaney, Meghan; DeBiasi, Roberta L.; Rostad, Christina A.; Burns, Jane C.; Chiu, Charles Y.; De Vlaminck, Iwijn
作者单位：Cornell University; University of California System; University of California San Francisco; Children's National Health System; Rady Childrens Hospital San Diego; University of California System; University of California San Diego; Emory University; Children's Healthcare of Atlanta (CHOA); Yale University; George Washington University; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI)
摘要：Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utility of circulating cell- free RNA (cfRNA) in plasma as an analyte for the differential diagnosis and characterization of pediatric inflammatory syndromes. We profiled cfRNA in 370 plasma samples from pediatric patients with a range of inflammatory conditions, i...
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作者：Martinez, Matias; Cai, Tianying; Yang, Beiming; Zhou, Zexi; Shankman, Stewart A.; Mittal, Vijay A.; Haase, Claudia M.; Qu, Yang
作者单位：Northwestern University; Northwestern University; Northwestern University; University of Minnesota System; University of Minnesota Twin Cities; University of Texas System; University of Texas Austin; Northwestern University; Northwestern University; Northwestern University; Northwestern University
摘要：The transition to adolescence is a critical period for mental health development. Socio- experiential environments play an important role in the emergence of depressive symptoms with some adolescents showing more sensitivity to social contexts than others. Drawing on recent developmental neuroscience advances, we examined whether hippocampal volume amplifies social context effects in the transition to adolescence. We analyzed 2- y longitudinal data from the Adolescent Brain Cognitive Developme...
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作者：Nagae, Takayuki; Takeda, Mitsuhiro; Noji, Tomoyasu; Saito, Keisuke; Aoyama, Hiroshi; Miyanoiri, Yohei; Ito, Yutaka; Kainosho, Masatsune; Hirose, Yuu; Ishikita, Hiroshi; Mishima, Masaki
作者单位：Tokyo University of Pharmacy & Life Sciences; University of Tokyo; University of Tokyo; University of Osaka; Tokyo Metropolitan University; Toyohashi University of Technology
摘要：Deprotonation or suppression of the pKa of the amino group of a lysine sidechain is a widely recognized phenomenon whereby the sidechain amino group transiently can act as a nucleophile at the active site of enzymatic reactions. However, a deprotonated lysine and its molecular interactions have not been directly experimentally detected. Here, we demonstrate a deprotonated lysine stably serving as an acceptor in a H- bond between the photosensor protein RcaE and its chromophore. Signal splittin...
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作者：Wang, Xiaolei; Dou, Ying; Hu, Jingchu; Chan, Celia Hoi- Ching; Li, Renhao; Rong, Li; Gong, Huarui; Deng, Jian; Yuen, Terrence Tsz- Tai; Lin, Xuansheng; He, Yige; Su, Canhui; Zhang, Bao - Zhong; Chan, Jasper Fuk- Woo; Yuen, Kwok - Yung; Chu, Hin; Huang, Jian - Dong
作者单位：University of Hong Kong; University of Hong Kong; University of Hong Kong; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Shandong University; University of Hong Kong; University of Hong Kong; University of Hong Kong; Sun Yat Sen University; University of Hong Kong
摘要：Developing an effective Staphylococcus aureus (S. aureus) vaccine has been a challenging endeavor, as demonstrated by numerous failed clinical trials over the years. In this study, we formulated a vaccine containing a highly conserved moonlighting protein, the pyruvate dehydrogenase complex E2 subunit (PDHC), and showed that it induced strong protective immunity against epidemiologically relevant staphylococcal strains in various murine disease models. While antibody responses contributed to b...
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作者：Zheng, Yujie; Zhu, Lijun; Ke, Changsheng; Li, Yu; Zhou, Zhiwen; Jiang, Mou; Wang, Fang; He, Pei; Zhou, Xin; Jiang, Zhong-Xing; Chen, Shizhen
作者单位：Chinese Academy of Sciences; Innovation Academy for Precision Measurement Science & Technology, CAS; Wuhan University; Huazhong University of Science & Technology; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS
摘要：The advent of drones has revolutionized various aspects of our lives, and in the realm of biological systems, molecular drones hold immense promise as magic bullets for major diseases. Herein, we introduce a unique class of fluorinated macromolecular amphiphiles, designed in the shape of jellyfish, serving as exemplary molecular drones for fluorine- 19 and targeted cancer therapy. Functioning akin to their mechanical counterparts, these biocompatible molecular drones autonomously assemble with...
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作者：Nunez, Jimmy Gonzalez; Paulose, Jayson; Mobius, Wolfram; Beller, Daniel A.
作者单位：Johns Hopkins University; University of Oregon; University of Exeter; University of Exeter
摘要：When biological populations expand into new territory, the evolutionary outcomes can be strongly influenced by genetic drift, the random fluctuations in allele frequencies. Meanwhile, spatial variability in the environment can also significantly influence the competition between subpopulations vying for space. Little is known about the interplay of these intrinsic and extrinsic sources of noise in population dynamics: When does environmental heterogeneity dominate over genetic drift or vice ve...
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作者：Guzikevits, Mika; Gordon-Hecker, Tom; Rekhtman, David; Salameh, Shaden; Israel, Salomon; Shayo, Moses; Gozal, David; Perry, Anat; Gileles-Hillel, Alex; Choshen-Hillel, Shoham
作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem; Ben-Gurion University of the Negev; Hebrew University of Jerusalem; Hadassah University Hospital; Hebrew University of Jerusalem; Hebrew University of Jerusalem; University of London; King's College London; University of Missouri System; University of Missouri Columbia; Marshall University; Hebrew University of Jerusalem; Hadassah University Hospital; Hebrew University of Jerusalem
摘要：In the pursuit of mental and physical health, effective pain management stands as a cornerstone. Here, we examine a potential sex bias in pain management. Leveraging insights from psychological research showing that females' pain is stereotypically judged as less intense than males' pain, we hypothesize that there may be tangible differences in pain management decisions based on patients' sex. Our investigation spans emergency department (ED) datasets from two countries, including discharge no...
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作者：von Hohenberg, Bernhard Clemm; Hager, Anselm
