2024

最新文章

• Caution urged for work with newly constructed human coronavirus AI翻译
  作者：Masters, Paul S.
  作者单位：Wadsworth Center
• Electric fields imbue enzyme reactivity by aligning active site fragment orbitals AI翻译
  作者：Eberhart, M. E.; Wilson, Timothy R.; Jones, T. E.; Alexandrova, Anastassia N.
  作者单位：Colorado School of Mines; United States Department of Energy (DOE); Los Alamos National Laboratory; University of California System; University of California Los Angeles
  摘要：It is broadly recognized that intramolecular electric fields, produced by the protein scaffold and acting on the active site, facilitate enzymatic catalysis. This field effect can be described by several theoretical models, each of which is intuitive to varying degrees. In this contribution, we show that a fundamental effect of electric fields is to generate electrostatic potentials that facilitate the energetic alignment of reactant frontier orbitals. We apply this model to demystify the impa...
• KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP signaling AI翻译
  作者：Liao, Yini; Muntean, Brian S.
  作者单位：University System of Georgia; Augusta University
  摘要：Dopamine transfers information to striatal neurons, and disrupted neurotransmission leads to motor deficits observed in movement disorders. Striatal dopamine converges the essential role of signal transduction in motor physiology. However, the relationship between dopamine decoding and AC5 regulation is unknown. Here, we utilized an unbiased global protein stability screen to identify Potassium Channel Tetramerization Domain 1 (KCTD1) as a key regulator of AC5 level that is mechanistically tie...
• Programmable heterogeneous lamellar lattice architecture for dual mechanical protection AI翻译
  作者：Tian, Yuanyuan; Zhang, Xin; Hou, Boyuan; Jarlov, Asker; Du, Chunyang; Zhou, Kun
  作者单位：Nanyang Technological University; Singapore Centre for 3D Printing; Nanyang Technological University; Northwestern Polytechnical University; National University of Defense Technology - China
  摘要：Shear bands frequently appear in lattice architectures subjected to compression, leading to an unstable stress-strain curve and global deformation. This deformation mechanism reduces their energy absorption and loading- bearing capacity and causes the architectures to prioritize mechanical protection of external components at the expense of the entire structure. Here, we leverage the design freedom offered by additive manufacturing and the geometrical relation of dual- phase nanolamellar cryst...
• The peptide hormone PjCLE1 stimulates haustorium formation in the parasitic plant Phtheirospermum japonicum AI翻译
  作者：Greifenhagen, Anne; Ruwe, Hannes; Zimmer, Victoria; Messerschmidt, Jana; Bhukya, Durga Prasad Naik; Kenea, Hawi Deressa; Schaller, Andreas; Spallek, Thomas
  作者单位：University Hohenheim; University of Gottingen
  摘要：Phtheirospermum japonicum is a hemiparasitic plant of the Orobanchaceae, the largest family of parasitic plants. It extracts water and nutrients from other plants through haustoria along its roots. Haustoriogenesis, the formation of haustoria, is initiated by host- derived haustorium- inducing factors (HIFs). The first step in haustoriogenesis is the development of parasitically inactive protohaustoria. Here, we report that an sufficient to induce protohaustorium formation. PjCLE1 hyperactivat...
• Health benefits of US light- duty vehicle electrification: Roles of fleet dynamics, clean electricity, and policy timing AI翻译
  作者：Schmitt, Jean; Hatzopoulou, Marianne; Abdul-Manan, Amir F. N.; MacLean, Heather L.; Posen, I. Daniel
  作者单位：University of Toronto
  摘要：We present a dynamic perspective to quantify the air quality-related health impacts of the electrification of light- duty vehicles in the United States between 2022 and 2050. Using a fleet turnover model and future electricity generation mix scenarios, we compare ambitious vehicle electrification to fleet renewal relying on newer internal combustion engine vehicles, without electric vehicles. The model includes vehicle- level pollutant emission factors and a reduced complexity air quality and ...
• A receptor for dual ligands governs plant immunity and hormone response and is targeted by a nematode effector AI翻译
  作者：Huang, Li; Yuan, Yulin; Ramirez, Chloe; Zhao, Zhe; Chen, Letian; Griebel, Thomas; Kud, Joanna; Kuhl, Joseph C.; Caplan, Allan; Dandurand, Louise-Marie; Xiao, Fangming
  作者单位：University of Idaho; South China Agricultural University; Guangdong Laboratory for Lingnan Modern Agriculture; Free University of Berlin; University of Arkansas System; University of Arkansas Fayetteville; University of Idaho
  摘要：In this study, we show that the potato ( Solanum tuberosum) pattern recognition receptor (PRR) NEMATODE- INDUCED LEUCINE-RICH REPEAT (LRR)-RLK1 (StNILR1) functions as a dual receptor, recognizing both nematode- associated molecular pattern ascaroside #18 (Ascr18) and plant hormone brassinosteroid (BR) to activate two different physiological outputs: pattern- triggered immunity (PTI) and BR response. Ascr18/BR- StNILR1 signaling requires the coreceptor potato BRASSINOSTEROID INSENSITIVE 1- ASSO...
• HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence (vol 121, e2306454120, 2024) AI翻译
  作者：Cui, Mengying; Yamano, Koji; Yamamoto, Kenichi; Yamamoto-Imoto, Hitomi; Minami, Satoshi; Yamamoto, Takeshi; Matsui, Sho; Kaminishi, Tatsuya; Shima, Takayuki; Ogura, Monami; Tsuchiya, Megumi; Nishino, Kohei; Layden, Brian T.; Kato, Hisakazu; Matsuda, Noriyuki; Yoshimor, Tamotsu; Nakamura, Shuhei
• The Drosophila tracheal terminal cell as a model for branching morphogenesis AI翻译
  作者：Gavrilchenko, Tatyana; Simpkins, Alison G.; Simpson, Tanner; Barrett, Lena A.; Hansen, Pauline; Shvartsman, Stanislav Y.; Schottenfeld-Roames, Jodi
  作者单位：Simons Foundation; Flatiron Institute; Princeton University; Princeton University; McKinsey & Company
  摘要：The terminal cells of the Drosophila larval tracheal system are perhaps the simplest delivery networks, providing an analogue for mammalian vascular growth and function in a system with many fewer components. These cells are a prime example of single-cell morphogenesis, branching significantly over time to adapt to the needs of the growing tissue they supply. While the genetic mechanisms governing local branching decisions have been studied extensively, an understanding of the emergence of a g...
• Signatures of criticality in efficient coding networks AI翻译
  作者：Safavi, Shervin; Chalk, Matthew; Logothetis, Nikos K.; Levina, Anna
  作者单位：Technische Universitat Dresden; Max Planck Society; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Eberhard Karls University of Tubingen
  摘要：The critical brain hypothesis states that the brain can benefit from operating close to a second-order phase transition. While it has been shown that several computational aspects of sensory processing (e.g., sensitivity to input) can be optimal in this regime, it is still unclear whether these computational benefits of criticality can be leveraged by neural systems performing behaviorally relevant computations. To address this question, we investigate signatures of criticality in networks opt...