Fluorinated macromolecular amphiphiles as prototypic molecular drones

• 成果类型: Article
• 署名作者: Zheng, Yujie; Zhu, Lijun; Ke, Changsheng; Li, Yu; Zhou, Zhiwen; Jiang, Mou; Wang, Fang; He, Pei; Zhou, Xin; Jiang, Zhong-Xing; Chen, Shizhen
• 署名单位: Chinese Academy of Sciences; Innovation Academy for Precision Measurement Science & Technology, CAS; Wuhan University; Huazhong University of Science & Technology; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-9746
• DOI: 10.1073/pnas.2405877121
• 发表日期: 2024-08-27
• 关键词: porphyrin-based theranostics; CHALLENGES; DESIGN; mri; nanomedicine; probes; cells

摘要

The advent of drones has revolutionized various aspects of our lives, and in the realm of biological systems, molecular drones hold immense promise as magic bullets for major diseases. Herein, we introduce a unique class of fluorinated macromolecular amphiphiles, designed in the shape of jellyfish, serving as exemplary molecular drones for fluorine- 19 and targeted cancer therapy. Functioning akin to their mechanical counterparts, these biocompatible molecular drones autonomously assemble with hydrophobic drugs to form uniform nanoparticles, facilitating efficient drug delivery into cells. The status of drug delivery can be tracked through aggregation- induced emission (AIE) of FLI and 19F MRI. Furthermore, when loaded with a heptamethine cyanine fluorescent dye IR- 780, these molecular drones enable near- infrared (NIR) FL detection of tumors and precise delivery of the photosensitizer. Similarly, when loaded with doxorubicin (DOX), they enable targeted chemotherapy with fluorescence resonance energy transfer (FRET) FL for real- time status updates, resulting in enhanced therapeutic efficacy. Compared to conventional drug delivery systems, molecular drones stand out for their simplicity, precise structure, versatility, and ability to provide instantaneous status updates. This study presents prototype molecular drones capable of executing fundamental drone functions, laying the groundwork for the development of more sophisticated molecular machines with significant biomedical implications.