Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity

• 成果类型: Article
• 署名作者: Martinez, Matias; Cai, Tianying; Yang, Beiming; Zhou, Zexi; Shankman, Stewart A.; Mittal, Vijay A.; Haase, Claudia M.; Qu, Yang
• 署名单位: Northwestern University; Northwestern University; Northwestern University; University of Minnesota System; University of Minnesota Twin Cities; University of Texas System; University of Texas Austin; Northwestern University; Northwestern University; Northwestern University; Northwestern University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-9743
• DOI: 10.1073/pnas.2321965121
• 发表日期: 2024-09-10
• 关键词: early-life adversity; childhood maltreatment; enriched environment; postmenopausal women; Missing Data; stress; brain; BEHAVIOR; axis; psychopathology

摘要

The transition to adolescence is a critical period for mental health development. Socio- experiential environments play an important role in the emergence of depressive symptoms with some adolescents showing more sensitivity to social contexts than others. Drawing on recent developmental neuroscience advances, we examined whether hippocampal volume amplifies social context effects in the transition to adolescence. We analyzed 2- y longitudinal data from the Adolescent Brain Cognitive Development (ABCD (R)) study in a diverse sample of 11,832 youth (mean age: 9.914 y; range: 8.917 to 11.083 y; 47.8% girls) from 21 sites across the United States. Socio- experiential environments (i.e., family conflict, primary caregiver's depressive symptoms, parental warmth, peer victimization, and prosocial school environment), hippocampal volume, and a wide range of demographic characteristics were measured at baseline. Youth's symptoms of major depressive disorder were assessed at both baseline and 2 y later. Multilevel mixed- effects linear regression analyses showed that negative social environments (i.e., family conflict, primary caregiver's depressive symptoms, and peer victimization) and the absence of positive social environments (i.e., parental warmth and prosocial school environment) predicted greater increases in youth's depressive symptoms over 2 y. Importantly, left hippocampal volume amplified social context effects such that youth with larger left hippocampal volume experienced greater increases in depressive symptoms in more negative and less positive social environments. Consistent with brain-environment interaction models of mental health, these findings underscore the importance of families, peers, and schools in the development of depression during the transition to adolescence and show how neural structure amplifies social context sensitivity.