2024

最新文章

• Structural basis for adhesin secretion by the outer- membrane usher in type 1 pili AI翻译
  作者：Bitter, Ryan M.; Zimmerman, Maxwell I.; Summers, Brock T.; Pinkner, Jerome S.; Dodson, Karen W.; Hultgren, Scott J.; Yuan, Peng
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
  摘要：Gram- negative bacteria produce chaperone-usher pathway pili, which are extracellular protein fibers tipped with an adhesive protein that binds to a receptor with stereochemical specificity to determine host and tissue tropism. The outer- membrane usher protein, together with a periplasmic chaperone, assembles thousands of pilin subunits into a highly ordered pilus fiber. The tip adhesin in complex with its cognate chaperone activates the usher to allow extrusion across the outer membrane. The...
• Dynamic in situ detection in iRhizo-Chip reveals diurnal fluctuations of Bacillus subtilis in the rhizosphere AI翻译
  作者：Dai, Hengyi; Wu, Binbin; Zhuang, Yajuan; Ren, Hao; Chen, Yanbo; Zhang, Fangzhou; Chu, Chiheng; Lv, Xiaofei; Xu, Jianming; Ma, Bin
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; China Jiliang University
  摘要：Effective colonization by microbe in the rhizosphere is critical for establishing a beneficial symbiotic relationship with the host plant. Bacillus subtilis, a soil- dwelling bacterium that is commonly found in association with plants and their rhizosphere, has garnered interest for its potential to enhance plant growth, suppress pathogens, and contribute to sustainable agricultural practices. However, research on the dynamic distribution of B. subtilis within the rhizosphere and its interacti...
• Unveiling the DHX15-G-patch interplay in retroviral RNA packaging AI翻译
  作者：Dostalkova, Alzbeta; Krizova, Ivana; Junkova, Petra; Rackova, Jana; Kapisheva, Marina; Novotny, Radim; Danda, Matej; Zvonarova, Karolina; Sinkovec, Larisa; Vecerkova, Katerina; Bednarova, Lucie; Ruml, Tomas; Rumlova, Michaela
  作者单位：University of Chemistry & Technology, Prague; Czech Academy of Sciences; Czech Academy of Sciences; Institute of Molecular Genetics of the Czech Academy of Sciences
  摘要：We explored how a simple retrovirus, Mason- Pfizer monkey virus (M-PMV) to facilitate its replication process, utilizes DHX15, a cellular RNA helicase, typically engaged in RNA processing. Through advanced genetic engineering techniques, we showed that M-PMV recruits DHX15 by mimicking cellular mechanisms, relocating it from the nucleus to the cytoplasm to aid in viral assembly. This interaction is essential for the correct packaging of the viral genome and critical for its infectivity. Our fi...
• Sensory integration of food and population density during the diapause exit decision involves insulin- like signaling in Caenorhabditis AI翻译
  作者：Zhang, Mark G.; Seyedolmohadesin, Maedeh; Mercado, Soraya Hawk; Tauffenberger, Arnaud; Park, Heenam; Finnen, Nerissa; Schroeder, Frank C.; Venkatachalam, Vivek; Sternberg, Paul W.
  作者单位：California Institute of Technology; Northeastern University; Cornell University; Boyce Thompson Institute for Plant Research; Cornell University
  摘要：Decisions made over long time scales, such as life cycle decisions, require coordinated interplay between sensory perception and sustained gene expression. The Caenorhabditis elegans dauer (or diapause) exit developmental decision requires sensory integration of population density and food availability to induce an all- or- nothing organismal- wide response, but the mechanism by which this occurs remains unknown. Here, we to be critical for dauer exit, perform sensory integration at both the l...
• Evolution of pH- sensitive transcription termination in Escherichia coli during adaptation to repeated long- term starvation AI翻译
  作者：Worthan, Sarah B.; McCarthy, Robert D. P.; Delaleau, Mildred; Stikeleather, Ryan; Bratton, Benjamin P.; Boudvillain, Marc; Behringer, Megan G.
  作者单位：Vanderbilt University; Vanderbilt University; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite de Orleans; Arizona State University; Arizona State University-Tempe; Vanderbilt University; Vanderbilt University
  摘要：Fluctuating environments that consist of regular cycles of co- occurring stress are a common challenge faced by cellular populations. For a population to thrive in constantly changing conditions, an ability to coordinate a rapid cellular response is essential. Here, we identify a mutation conferring an arginine-to- histidine (Arg to His) substitution in the transcription terminator Rho. The rho R109H mutation frequently arose in Escherichia coli populations experimentally evolved under repeate...
• Revisiting the four Hexapoda classes: Protura as the sister group to all other hexapods AI翻译
  作者：Du, Shiyu; Tihelka, Erik; Yu, Daoyuan; Chen, Wan-Jun; Bu, Yun; Cai, Chenyang; Engel, Michael S.; Luan, Yun-Xia; Zhang, Feng
  作者单位：Nanjing Agricultural University; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Cambridge; Nanjing Agricultural University; American Museum of Natural History (AMNH); Universidad Nacional Mayor de San Marcos; Universidad Nacional Mayor de San Marcos; South China Normal University
  摘要：Insects represent the most diverse animal group, yet previous phylogenetic analyses based on morphological and molecular data have failed to agree on the evolutionary relationships of early insects and their six-legged relatives (together constituting the clade Hexapoda). In particular, the phylogenetic positions of the three early-diverging hexapod lineages-the coneheads (Protura), springtails (Collembola), and two-pronged bristletails (Diplura)-have been debated for over a century, with alte...
• Stepwise assembly of the AP2 endocytic clathrin adaptor complex AI翻译
  作者：Hollopeter, Gunther
  作者单位：Cornell University
• Early characterization of excitation-contraction coupling and SLO-2 channel properties in Caenorhabditis elegans muscle cells AI翻译
  作者：Allard, Bruno
  作者单位：Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS)
• Unsupervised pattern identification in spatial gene expression atlas reveals mouse brain regions beyond established ontology AI翻译
  作者：Cahill, Robert; Wang, Yu; Xian, R. Patrick; Lee, Alex J.; Zeng, Hongkui; Yu, Bin; Tasic, Bosiljka; Abbasi, Reza
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California Berkeley; Allen Institute for Brain Science; University of California System; University of California Berkeley; University of California System; University of California San Francisco
  摘要：The rapid growth of large- scale spatial gene expression data demands efficient and reliable computational tools to extract major trends of gene expression in their native spatial context. Here, we used stability- driven unsupervised learning (i.e., staNMF) to identify principal patterns (PPs) of 3D gene expression profiles and understand spatial gene distribution and anatomical localization at the whole mouse brain level. Our subsequent spatial correlation analysis systematically compared the...
• Reply to Jautzy et al.: Considerations on methane equilibrium-do not forget to add the pepper AI翻译
  作者：Chowdhury, Anirban; Ventura, Gregory T.; Owino, Yaisa; Lalk, Ellen J.; MacAdam, Natasha; Dooma, John M.; Ono, Shuhei; Fowler, Martin; MacDonald, Adam; MacRae, R. Andrew; Hubert, Casey R. J.; Bentley, Jeremy N.; Kerr, Mitchell J.
  作者单位：Saint Marys University - Canada; Massachusetts Institute of Technology (MIT); University of Calgary