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作者:Muralidhar, Krishnamurty; Ruggles, Steven; Ferrer, Josep Domingo -; Sanchez, David
作者单位:University of Oklahoma System; University of Oklahoma - Norman; University of Minnesota System; University of Minnesota Twin Cities; Universitat Rovira i Virgili
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作者:Freeman, Jacob; Robinson, Erick; Bird, Darcy; Hardh, Robert J.; Mauldin, Raymond P.; Anderies, John M.
作者单位:Utah System of Higher Education; Utah State University; Utah System of Higher Education; Utah State University; Nevada System of Higher Education (NSHE); Desert Research Institute NSHE; Arizona State University; Arizona State University-Tempe; Washington State University; State University System of Florida; University of Florida; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio; Arizona State University; Arizona State University-Tempe
摘要:Over the last 12,000 y, human populations have expanded and transformed critical earth systems. Yet, a key unresolved question in the environmental and social sciences remains: Why did human populations grow and, sometimes, decline in the first place? Our research builds on 20 y of archaeological research studying the deep time dynamics of human populations to propose an explanation for the long-term growth and stability of human populations. Innovations in the productive capacity of populatio...
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作者:Trosta, Wiebke; Trevora, Caitlyn; Fernandeza, Natalia; Steinera, Florence; Fruehholza, Sascha
作者单位:University of Zurich; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Oslo
摘要:Music is powerful in conveying emotions and triggering affective brain mechanisms. Affective brain responses in previous studies were however rather inconsistent, potentially because of the non- adaptive nature of recorded music used so far. Live music instead can be dynamic and adaptive and is often modulated in response to audience feedback to maximize emotional responses in listeners. Here, we introduce a setup for studying emotional responses to live music in a closed - loop neurofeedback ...
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作者:Twomey, Colin R.; Brainard, David H.; Plotkin, Joshua B.
作者单位:University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要:Color naming in natural languages is not arbitrary: It reflects efficient partitions of 104, 1436-1441 (2007)] modulated by the relative needs to communicate about Sci. U.S.A. 118, e2109237118 (2021)]. These psychophysical and communicative constraints help explain why languages around the world have remarkably similar, but not identical, mappings of colors to color terms. Languages converge on a small set of efficient representations.But languages also evolve, and the number of terms in a col...
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作者:Azam, Sikandar; Armijo, Kaitlyn S.; Weindel, Chi G.; Chapman, Morgan J.; Devigne, Alice; Nakagawa, Shinichi; Hirose, Tetsuro; Carpenter, Susan; Watson, Robert O.; Patrick, Kristin L.
作者单位:Texas A&M University System; Texas A&M University College Station; University of California System; University of California Santa Cruz; Hokkaido University; University of Osaka
摘要:To ensure a robust immune response to pathogens without risking immunopathology, the kinetics and amplitude of inflammatory gene expression in macrophages need to be exquisitely well controlled. There is a growing appreciation for stress- responsive membraneless organelles (MLOs) regulating various steps of eukaryotic gene expression in response to extrinsic cues. Here, we implicate the nuclear paraspeckle, a highly ordered biomolecular condensate that nucleates on the Neat1 lncRNA, in tuning ...
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作者:Jeon, Sanghyun; Kamble, Yash Laxman; Kang, Haisu; Shi, Jiachun; Wade, Matthew A.; Patel, Bijal B.; Pan, Tianyuan; Rogers, Simon A.; Sing, Charles E.; Guironnet, Damien; Diao, Ying
作者单位:University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要:Additive manufacturing capable of controlling and dynamically modulating structures down to the nanoscopic scale remains challenging. By marrying additive manufacturing with self- assembly, we develop a UV (ultra- violet)- assisted direct ink write approach for on- the- fly modulation of structural color by programming the assembly kinetics through photo- cross- linking. We design a photo- cross- linkable bottlebrush block copolymer solution as a printing ink that exhibits vibrant structural c...
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作者:Ayres, Ian; Katz, Tamar Kricheli; Regev, Tali
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作者:Chen, Yali; Chen, Kun; Zhu, Ha; Qin, Hua; Liu, Juan; Cao, Xuetao
作者单位:Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Naval Medical University; Tongji University; Nankai University
摘要:Coordinated metabolic reprogramming and epigenetic remodeling are critical for mod-ulating T cell function and differentiation. However, how the epigenetic modification controls Th17/Treg cell balance via metabolic reprogramming remains obscure. Here, we find that Setd2, a histone H3K36 trimethyltransferase, suppresses Th17 develop-ment but promotes iTreg cell polarization via phospholipid remodeling. Mechanistically, Setd2 up- regulates transcriptional expression of lysophosphatidylcholine ac...
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作者:Harrison, Neil; Chappell, Greta L.; Tobash, Paul H.
作者单位:United States Department of Energy (DOE); Los Alamos National Laboratory; United States Department of Energy (DOE); Los Alamos National Laboratory
摘要:On cooling from the melt, plutonium (Pu) undergoes a series of structural transformations accompanied by a approximate to 28% reduction in volume from its delta phase to its a phase at low temperatures. While Pu's partially filled 5f -electron shells are known to be involved, their precise role in the transformations has remained unclear. By using calorimetry measurements on a-Pu and gallium -stabilized delta-Pu combined with resonant ultrasound and X-ray scattering data to account for the ano...
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作者:Hong, Hye- Rim; Prince, Cassidy R.; Tetreault, Daniel D.; Wu, Letian; Feaga, Heather A.
作者单位:Cornell University
摘要:Protein synthesis is performed by the ribosome and a host of highly conserved elongation factors. Elongation factor P (EF-P) prevents ribosome stalling at difficult - to- translate sequences, such as polyproline tracts. In bacteria, phenotypes associated with efp deletion range from modest to lethal, suggesting that some species encode an additional translation factor that has similar function to EF-P. Here we identify YfmR as a translation factor that is essential in the absence of EF-P in Ba...