2024

最新文章

• Spike- timing- dependent plasticity induction reveals dissociable supplementary- and premotor-motor pathways to automatic imitation AI翻译
  作者：Turrini, Sonia; Fiori, Francesca; Bevacqua, Naomi; Saracini, Chiara; Lucero, Boris; Candidi, Matteo; Avenanti, Alessio
  作者单位：University of Bologna; University Campus Bio-Medico - Rome Italy; Sapienza University Rome; Universidad Catolica del Maule
  摘要：Humans tend to spontaneously imitate others' behavior, even when detrimental to the task at hand. The action observation network (AON) is consistently recruited during imitative tasks. However, whether automatic imitation is mediated by cortico - cortical projections from AON regions to the primary motor cortex (M1) remains speculative. Similarly, the potentially dissociable role of AON - to - M1 pathways involving the ventral premotor cortex (PMv) or supplementary motor area (SMA) in automati...
• Identification of two archaeal GDGT lipid-modifying proteins reveals diverse microbes capable of GMGT biosynthesis and modification AI翻译
  作者：Garcia, Andy A.; Chadwick, Grayson L.; Liu, Xiao- Lei; V. Welander, Paula
  作者单位：Stanford University; University of California System; University of California Berkeley; University of Oklahoma System; University of Oklahoma - Norman
  摘要：Archaea produce unique membrane - spanning lipids (MSLs), termed glycerol dialkyl glycerol tetraethers (GDGTs), which aid in adaptive responses to various environmental challenges. GDGTs can be modified through cyclization, cross - linking, methylation, hydroxylation, and desaturation, resulting in structurally distinct GDGT lipids. Here, we report the identification of radical SAM proteins responsible for two of these modifications-a glycerol monoalkyl glycerol tetraether (GMGT) synthase (Gms...
• Dynamics of multicellular swirling on micropatterned substrates AI翻译
  作者：Li, Xi; Chen, Bin
  作者单位：Zhejiang University; Zhejiang University
  摘要：Chirality plays a crucial role in biology, as it is highly conserved and fundamentally important in the developmental process. To better understand the relationship between the chirality of individual cells and that of tissues and organisms, we develop a generalized mechanics model of chiral polarized particles to investigate the swirling dynamics of cell populations on substrates. Our analysis reveals that cells with the same chirality can form distinct chiral patterns on ring - shaped or rec...
• The role of shear forces in primary and secondary nucleation of amyloid fibrils AI翻译
  作者：Axell, Emil; Hu, Jing; Lindberg, Max; Dear, Alexander J.; Ortigosa-Pascual, Lei; Andrzejewska, Ewa A.; Sneideriene, Greta; Thacker, Dev; Knowles, Tuomas P. J.; Sparr, Emma; Linse, Sara
  作者单位：Lund University; Lund University; University of Cambridge
  摘要：Shear forces affect self -assembly processes ranging from crystallization to fiber formation. Here, the effect of mild agitation on amyloid fibril formation was explored for four peptides and investigated in detail for A f3 42, which is associated with Alzheimer's disease. To gain mechanistic insights into the effect of mild agitation, nonseeded and seeded aggregation reactions were set up at various peptide concentrations with and without an inhibitor. First, an effect on fibril fragmentation...
• Unconventional mechanism of action and resistance to rapalogs in renal cancer AI翻译
  作者：Yang, Juan; Butti, Ramesh; Cohn, Shannon; Toffessi-Tcheuyap, Vanina; Mal, Arijit; Nguyen, Mylinh; Stevens, Christina; Christie, Alana; Mishra, Akhilesh; Ma, Yuanqing; Kim, Jiwoong; Abraham, Robert; Kapur, Payal; Hammer, Robert E.; Brugarolas, James
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Pfizer; Pfizer USA; University of Texas System; University of Texas Southwestern Medical Center
  摘要：mTORC1 is aberrantly activated in renal cell carcinoma (RCC) and is targeted by rapalogs. As for other targeted therapies, rapalogs clinical utility is limited by the development of resistance. Resistance often results from target mutation, but mTOR mutations are rarely found in RCC. As in humans, prolonged rapalog treatment of RCC tumorgrafts (TGs) led to resistance. Unexpectedly, explants from resistant tumors became sensitive both in culture and in subsequent transplants in mice. Notably, r...
• The physical and cellular mechanism of structural color change in zebrafish AI翻译
  作者：Gur, Dvir; Moore, Andrew S.; Deis, Rachael; Song, Pang; Wu, Xufeng; Pinkas, Iddo; Deo, Claire; Iyer, Nirmala; Hess, Harald F.; Hammer, John A.; Lippincott-Schwartz, Jennifer
  作者单位：Weizmann Institute of Science; Howard Hughes Medical Institute; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); Weizmann Institute of Science
  摘要：Many animals exhibit remarkable colors that are produced by the constructive interference of light reflected from arrays of intracellular guanine crystals. These animals can fine - tune their crystal - based structural colors to communicate with each other, regulate body temperature, and create camouflage. While it is known that these changes in color are caused by changes in the angle of the crystal arrays relative to incident light, the cellular machinery that drives color change is not unde...
• A useful formula for periodic Jacobi matrices on trees AI翻译
  作者：Banks, Jess; Breuer, Jonathan; Garza-Vargas, Jorge; Seelig, Eyal; Simon, Barry
  作者单位：University of California System; University of California Berkeley; Hebrew University of Jerusalem; California Institute of Technology; California Institute of Technology; California Institute of Technology
  摘要：We introduce a function of the density of states for periodic Jacobi matrices on trees and prove a useful formula for it in terms of entries of the resolvent of the matrix and its half -tree restrictions. This formula is closely related to the one-dimensional Thouless formula and associates a natural phase with points in the bands. This allows streamlined proofs of the gap labeling and Aomoto index theorems. We give a complete proof of gap labeling and sketch the proof of the Aomoto index theo...
• Deep sequencing of Phox2a nuclei reveals five classes of anterolateral system neurons AI翻译
  作者：Bell, Andrew M.; Utting, Charlotte; Dickie, Allen C.; Kucharczyk, Mateusz W.; Quillet, Raphaelle; Gutierrez-Mecinas, Maria; Razlan, Aimi N. B.; Cooper, Andrew H.; Lan, Yuxuan; Hachisuka, Junichi; Weir, Greg A.; Bannister, Kirsty; Watanabe, Masahiko; Kania, Artur; Hoon, Mark A.; Macaulay, Iain C.; Denk, Franziska; Todd, Andrew J.
  作者单位：University of Glasgow; University of Glasgow; University of London; King's College London; Hokkaido University; Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR)
  摘要：The anterolateral system (ALS) is a major ascending pathway from the spinal cord that projects to multiple brain areas and underlies the perception of pain, itch, and skin temperature. Despite its importance, our understanding of this system has been hampered by the considerable functional and molecular diversity of its constituent cells. Here, we use fluorescence - activated cell sorting to isolate ALS neurons belonging to the Phox2a - lineage for single - nucleus RNA sequencing. We reveal fi...
• Preictal dysfunctions of inhibitory interneurons paradoxically lead to their rebound hyperactivity and to low- voltage- fast onset seizures in Dravet syndrome AI翻译
  作者：Capitano, Fabrizio; Kuchenbuch, Mathieu; Lavigne, Jennifer; Chaptoukaev, Hava; Zuluaga, Maria A.; Lorenzi, Marco; Nabbout, Rima; Mantegazza, Massimo
  作者单位：Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); IMT - Institut Mines-Telecom; EURECOM; Universite Cote d'Azur
  摘要：Epilepsies have numerous specific mechanisms. The understanding of neural dynamics leading to seizures is important for disclosing pathological mechanisms and developing therapeutic approaches. We investigated electrographic activities and neural dynamics leading to convulsive seizures in patients and mouse models of Dravet syndrome (DS), a developmental and epileptic encephalopathy in which hypoexcitability of GABAergic neurons is considered to be the main dysfunction. We analyzed EEGs from D...
• Zoom out: An intervention on the virtual learning environment improves minority students' grades in two field experiments in Israel AI翻译
  作者：Endevelt, Kinneret; Halperin, Eran; Porat, Roni
  作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem; Hebrew University of Jerusalem
  摘要：Closing the achievement gap for minority students in higher education requires addressing the lack of belonging these students experience. This paper introduces a psychological intervention that strategically targets key elements within the learning environment to foster the success of minority students. The intervention sought to enhance Palestinian minority student's sense of belonging by increasing the presence of their native language. We tested the effectiveness of the intervention in two...