2024

最新文章

• Monkeypox virus infection of human astrocytes causes gasdermin B cleavage and pyroptosis AI翻译
  作者：Mahabadi, Hajar Miranzadeh; Lin, Y. C. James; Ogando, Natacha S.; Moussa, Eman W.; Mohammadzadeh, Nazanin; Julien, Oliver; Alto, Neal M.; Noyce, Ryan S.; Evans, David H.; Power, Christopher
  作者单位：University of Alberta; University of Alberta; University of Alberta; University of Texas System; University of Texas Southwestern Medical Center; University of Alberta
  摘要：Monkeypox virus (MPXV) infections in humans cause neurological disorders while studies of MPXV- infected animals indicate that the virus penetrates the brain. Pyroptosis is an inflammatory type of regulated cell death, resulting from plasma membrane rupture (PMR) due to oligomerization of cleaved gasdermins to cause membrane pore formation. Herein, we investigated the human neural cell tropism of MPXV compared to another orthopoxvirus, vaccinia virus (VACV), as well as its effects on immune re...
• Enhancing ion selectivity by tuning solvation abilities of covalent- organic- framework membranes AI翻译
  作者：Meng, Qing-Wei; Zhu, Xincheng; Xian, Weipeng; Wang, Sai; Zhang, Zhengqing; Zheng, Liping; Dai, Zhifeng; Yin, Hong; Ma, Shengqian; Sun, Qi
  作者单位：Zhejiang University; Tiangong University; Zhejiang Sci-Tech University; University of North Texas System; University of North Texas Denton
  摘要：Understanding the molecular - level mechanisms involved in transmembrane ion selectivity is essential for optimizing membrane separation performance. In this study, we reveal our observations regarding the transmembrane behavior of Li + and Mg 2+ ions as a response to the changing pore solvation abilities of the covalent - organic - framework (COF) membranes. These abilities were manipulated by adjusting the lengths of the oligoether segments attached to the pore channels. Through comparative ...
• KAT8-catalyzed lactylation promotes eEF1A2-mediated protein synthesis and colorectal carcinogenesis AI翻译
  作者：Xie, Bingteng; Zhang, Mengdi; Li, Jie; Cui, Jianxin; Zhang, Pengju; Liu, Fangming; Wu, Yuxi; Deng, Weiwei; Ma, Jihong; Li, Xinyu; Pan, Bingchen; Zhang, Baohui; Zhang, Hongbing; Luo, Aiqin; Xu, Yinzhe; Li, Mo; Pu, Yang
  作者单位：Beijing Institute of Technology; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese People's Liberation Army General Hospital; Chinese People's Liberation Army General Hospital; University of Virginia; China Medical University; Chinese People's Liberation Army General Hospital
  摘要：Aberrant lysine lactylation (Kla) is associated with various diseases which are caused by excessive glycolysis metabolism. However, the regulatory molecules and downstream protein targets of Kla remain largely unclear. Here, we observed a global Kla abundance profile in colorectal cancer (CRC) that negatively correlates with prognosis. Among lactylated proteins detected in CRC, lactylation of eEF1A2K408 resulted in boosted translation elongation and enhanced protein synthesis which contributed...
• In vivo functional phenotypes from a computational epistatic model of evolution AI翻译
  作者：Alvarez, Sophia; Nartey, Charisse M.; Mercado, Nicholas; de la Paz, Jose Alberto; Huseinbegovic, Tea; Morcos, Faruck
  作者单位：University of Texas System; University of Texas Dallas; University of Texas System; University of Texas Dallas; University of Texas System; University of Texas Dallas
  摘要：Computational models of evolution are valuable for understanding the dynamics of sequence variation, to infer phylogenetic relationships or potential evolutionary pathways and for biomedical and industrial applications. Despite these benefits, few have validated their propensities to generate outputs with in vivo functionality, which would enhance their value as accurate and interpretable evolutionary algorithms. We demonstrate the power of epistasis inferred from natural protein families to e...
• Coordination of rhythmic RNA synthesis and degradation orchestrates 24-and 12-h RNA expression patterns in mouse fibroblasts AI翻译
  作者：Unruh, Benjamin A.; Weidemann, Douglas E.; Miao, Lin; Kojima, Shihoko
  作者单位：Virginia Polytechnic Institute & State University
  摘要：Circadian RNA expression is essential to ultimately regulate a plethora of downstream rhythmic biochemical, physiological, and behavioral processes. Both transcriptional and posttranscriptional mechanisms are considered important to drive rhythmic RNA expression; however, the extent to which each regulatory process contributes to the rhythmic RNA expression remains controversial. To systematically address this, we monitored RNA dynamics using metabolic RNA labeling technology during a circadia...
• A mouse model to distinguish NLRP6-mediated inflammasome- dependent and- independent functions AI翻译
  作者：Li, Runzhi; Zan, Yang; Wang, Decai; Chen, Xuequn; Wang, Anmin; Tan, Haoyuan; Zhang, Guorong; Ding, Siyuan; Shen, Chen; Wu, Hao; Zhu, Shu
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Washington University (WUSTL); Washington University (WUSTL); Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM)
  摘要：The NOD - like receptor (NLR) family pyrin domain containing 6 (NLRP6) serves as a sensor for microbial dsRNA or lipoteichoic acid (LTA) in intestinal epithelial cells (IECs), and initiating multiple pathways including inflammasome pathway and type I interferon (IFN) pathway, or regulating nuclear factor-kappa B (NF-kappa B) and mitogen- activated protein kinase (MAPK) pathways. NLRP6 can exert its function in both inflammasome- dependent and inflammasome- independent manners. However, there i...
• A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer AI翻译
  作者：Cencic, Regina; Im, Young K.; Naineni, Sai Kiran; Moustafa-Kamal, Mohamed; Jovanovic, Predrag; Sabourin, Valerie; Annis, Matthew G.; Robert, Francis; Schmeing, T. Martin; Koromilas, Antonis; Paquet, Marilene; Teodoro, Jose G.; Huang, Sidong; Siegel, Peter M.; Topisirovic, Ivan; Ursini-Siegel, Josie; Pelletier, Jerry
  作者单位：McGill University; McGill University; Lady Davis Institute; McGill University; McGill University; Universite de Montreal; McGill University
  摘要：In this study, we aimed to address the current limitations of therapies for macro-metastatic triple-negative breast cancer (TNBC) and provide a therapeutic lead that overcomes the high degree of heterogeneity associated with this disease. Specifically, we focused on well-documented but clinically underexploited cancer-fueling perturbations in mRNA translation as a potential therapeutic vulnerability. We therefore developed an orally bioavailable rocaglate-based molecule, MG-002, which hinders ...
• High UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma AI翻译
  作者：Duan, Mingrui; Song, Shenghan; Wasserman, Hana; Lee, Po-Hsuen; Liu, Ke Jian; Gordan, Raluca; He, Yi; Mao, Peng
  作者单位：University of New Mexico; University of New Mexico; University of New Mexico; Duke University; State University of New York (SUNY) System; Stony Brook University; Duke University; Duke University; Duke University
  摘要：Noncoding mutation hotspots have been identified in melanoma and many of them occur at the binding sites of E26 transformation-specific (ETS) proteins; however, their formation mechanism and functional impacts are not fully understood. Here, we used UV (Ultraviolet) damage sequencing data and analyzed cyclobutane pyrimidine dimer (CPD) formation, DNA repair, and CPD deamination in human cells at single-nucleotide resolution. Our data show prominent CPD hotspots immediately after UV irradiation...
• Interfacial solvation-structure regulation for stable Li metal anode by a desolvation coating technique AI翻译
  作者：Li, Guo-Xing; Lennartz, Peter; Koverga, Volodymyr; Kou, Rong; Au Nguyen; Jiang, Heng; Liao, Meng; Wang, Daiwei; Dandu, Naveen; Zepeda, Michael; Wang, Haiying; Wang, Ke; Ngo, Anh T.; Brunklaus, Gunther; Wang, Donghai
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Helmholtz Association; Research Center Julich; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; United States Department of Energy (DOE); Argonne National Laboratory; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：Rechargeable lithium (Li) metal batteries face challenges in achieving stable cycling due to the instability of the solid electrolyte interphase (SEI). The Li-ion solvation structure and its desolvation process are crucial for the formation of a stable SEI on Li metal anodes and improving Li plating/stripping kinetics. This research introduces an interfacial desolvation coating technique to actively modulate the Li-ion solvation structure at the Li metal interface and regulate the participatio...
• Tumor resistance to anti-mesothelin CAR-T cells caused by binding to shed mesothelin is overcome by targeting a juxtamembrane epitope AI翻译
  作者：Liu, X. F.; Onda, M.; Schlomer, J.; Bassel, L.; Kozlov, S.; Tai, C. -H.; Zhou, Q.; Liu, W.; Tsao, H. -E.; Hassan, R.; Ho, M.; Pastan, I.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
  摘要：Despite many clinical trials, CAR-T cells are not yet approved for human solid tumor therapy. One popular target is mesothelin (MSLN) which is highly expressed on the surface of about 30% of cancers including mesothelioma and cancers of the ovary, pancreas, and lung. MSLN is shed by proteases that cleave near the C terminus, leaving a short peptide attached to the cell. Most anti-MSLN antibodies bind to shed MSLN, which can prevent their binding to target cells. To overcome this limitation, we...