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作者：Li, Chengbei; Kaur, Amanpreet; Pavlidaki, Alexia; Spenle, Caroline; Rajnpreht, Irena; Donnadieu, Emmanuel; Salome, Nathalie; Molitor, Anne; Carapito, Raphael; Wack, Fanny; Erne, William; Lefebvre, Olivier; Averous, Gerlinde; Mitrentsi, Ioanna; Loustau, Thomas; Orend, Gertraud
作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; CHU Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); CHU Strasbourg; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg
摘要：Tumor- targeted therapies have often been inefficient due to the lack of concomitant control over the tumor microenvironment. Using an immunocompetent autologous breast cancer model, we investigated a MAtrix REgulating MOtif (MAREMO)- mimicking peptide, which inhibits the protumorigenic extracellular matrix (ECM) molecule tenascin-C that activates several cancer hallmarks. In cultured cells, targeting the MAREMO blocks tenascin-C signaling involved in cell adhesion and immune- suppression by i...
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作者：Williams, Darian; Glasstetter, Logan M.; Jong, Tiffany T.; Chen, Tiffany; Kapoor, Abhijeet; Zhu, Sha; Zhu, Yanping; Calvo, Raul; Gehrlein, Alexandra; Wong, Kimberly; Hogan, Andrew N.; Vocadlo, David J.; Jagasia, Ravi; Marugan, Juan J.; Sidransky, Ellen; Henderson, Mark J.; Chen, Yu
作者单位：National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS); National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); Simon Fraser University; Simon Fraser University; Roche Holding
摘要：Glucocerebrosidase (GCase) is implicated in both a rare, monogenic disorder (Gaucher disease, GD) and a common, multifactorial condition (Parkinson's disease, PD); hence, it is an urgent therapeutic target. To identify correctors of severe protein misfolding and trafficking obstruction manifested by the pathogenic L444P- variant of GCase, we developed a suite of quantitative, high- throughput, cell- based assays. First, we labeled GCase with a small proluminescent HiBiT peptide reporter tag, e...
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作者：van de Water, Jeroen A. J. M.; Bagci-Onder, Tugba; Agarwal, Aayush S.; Wakimoto, Hiroaki; Roovers, Rob C.; Zhu, Yanni; Kasmieh, Randa; Bhere, Deepak; Henegouwen, Paul M. P. Van Bergen En; Shah, Khalid
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作者：Kobylkov, Dmitry; Salva, Orsola Rosa -; Zanon, Mirko; Vallortigara, Giorgio
作者单位：University of Trento
摘要：Shortly after birth, both na & iuml;ve animals and newborn babies exhibit a spontaneous attraction to faces and face- like stimuli. While neurons selectively responding to faces have been found in the inferotemporal cortex of adult primates, face- selective domains in the brains of young monkeys seem to develop only later in life after exposure to faces. This has fueled a debate on the role of experience in the development of face- detector mechanisms, since face preferences are well documente...
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作者：Kamei, Noriyasu; Ikeda, Kento; Ohmoto, Yuka; Fujisaki, Seita; Shirata, Ryusei; Maki, Maya; Miyata, Mika; Miyauchi, Yuki; Nishiyama, Nanaka; Yamada, Mana; Ohigashi, Yuna; Takeda-Morishita, Mariko
作者单位：Kobe Gakuin University
摘要：Hippocampal neurons can be the first to be impaired with neurodegenerative disorders, including Alzheimer's disease (AD). Most drug candidates for causal therapy of AD cannot either enter the brain or accumulate around hippocampal neurons. Here, we genetically engineered insulin- fusion proteins, called hippocampal neuron-targeting (Ht) proteins, for targeting protein drugs to hippocampal neurons because insulin tends to accumulate in the neuronal cell layers of the hippocampus. In vitro exami...
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作者：Spatafora-Salazar, Aldo; Lobmeyer, Dana M.; Cunha, Lucas H. P.; Joshi, Kedar; Biswal, Sibanilisa
作者单位：Rice University; Georgetown University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) Goa
摘要：Precise control at the colloidal scale is one of the most promising bottom-up approaches to fabricating new materials and devices with tunable and precisely engineered properties. Magnetically driven colloidal assembly offers great versatility because of the ability to externally tune particle-particle interactions and to construct a host of particle arrangements. However, despite previous efforts to probe the parameter space, global orientational control in conjunction with two-dimensional mi...
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作者：Bai, Yun- Hao; Tang, Zhiyao
作者单位：Peking University; Peking University
摘要：The increasing duration of drought induced by global climate change has reduced forest productivity. Biodiversity is believed to mitigate the effects of drought, thereby enhancing the stability of tree growth. However, the effects of species richness on tree growth stability under droughts with different durations remain uncertain. Here, we used tree ring data from 4,072 sites globally, combined with climate and plant richness data, to evaluate the effects of species richness on the resistance...
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作者：Zhao, Qingkun; Zhu, Qi; Zhang, Zhenghao; Yin, Binglun; Gao, Huajian; Zhou, Haofei
作者单位：Zhejiang University; Nanyang Technological University; Tsinghua University
摘要：Hydrogen, the lightest and most abundant element in the universe, plays essential roles in a variety of clean energy technologies and industrial processes. For over a century, it has been known that hydrogen can significantly degrade the mechanical properties of materials, leading to issues like hydrogen embrittlement. A major challenge that has significantly limited scientific advances in this field is that light atoms like hydrogen are difficult to image, even with state- of- the- art micros...
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作者：Chimileski, Scott; Borisy, Gary G.; Dewhirst, Floyd E.; Welch, Jessica L. Mark
作者单位：Marine Biological Laboratory - Woods Hole; Harvard University; Harvard School of Dental Medicine
摘要：Organisms display an immense variety of shapes, sizes, and reproductive strategies. At microscopic scales, bacterial cell morphology and growth dynamics are adaptive traits that influence the spatial organization of microbial communities. In one such commumatruchotii cells forms the core of bacterial consortia known as hedgehogs, but the processes that generate these structures are unclear. Here, using live- cell time- lapse microscopy and fluorescent D- amino acids to track peptidoglycan bios...
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作者：Dasgupta, Sanjoy; Meirovitch, Yaron; Zheng, Xingyu; Bush, Inle; Lichtman, Jeff W.; Navlakha, Saket
作者单位：University of California System; University of California San Diego; Harvard University; Harvard University; Cold Spring Harbor Laboratory
摘要：Finding optimal bipartite matchings-e.g., matching medical students to hospitals for residency, items to buyers in an auction, or papers to reviewers for peer review-is a fundamental combinatorial optimization problem. We found a distributed algorithm for computing matchings by studying the development of the neuromuscular circuit. The neuromuscular circuit can be viewed as a bipartite graph formed between motor neurons and muscle fibers. In newborn animals, neurons and fibers are densely conn...
