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作者：Friedman, David J.; Leone, Dominick A.; Amador, Juan Jose; Kupferman, Joseph; Francey, Lauren J.; Lopez-Pilarte, Damaris; Lau, Jorge; Delgado, Iris; Yih, W. Katherine; Salinas, Alejandro; Wang, Minxian; Genovese, Giulio; Shah, Shrijal; Kelly, Jessica; Tattersfield, Calum F.; Raines, Nathan H.; Amador, Magaly; Dias, Leny; Pitsillides, Achilleas; Rubio, Oriana Ramirez-; Amador, Alda G.; Cortopassi, Marissa; Applebaum, Katie M.; Alper, Seth L.; Banks, Alex S.; Mcclean, Michael D.; Leibler, Jessica H.; Scammell, Madeleine K.; Dupuis, Josee; Brooks, Daniel R.
作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Boston University; Harvard University; Harvard Medical School; Harvard Pilgrim Health Care; Boston University; ISGlobal; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; George Washington University; Boston University; McGill University
摘要：Mesoamerican nephropathy (MeN) is a progressive kidney disease found on the Pacific coast of Central America primarily in young male agricultural workers without typical kidney disease risk factors. While it is generally accepted that environmental exposures contribute to MeN, we hypothesized that there was also an important genetic component. We performed a genome-wide association study comparing individuals with MeN versus individuals with normal kidney function. We found that Native America...
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作者：Kornhuber, Kai; Bartusek, Samuel; Seager, Richard; Schellnhuber, Hans Joachim; Ting, Mingfang
作者单位：International Institute for Applied Systems Analysis (IIASA); Columbia University; Columbia University; Columbia University
摘要：Multiple recent record- shattering weather events raise questions about the adequacy of climate models to effectively predict and prepare for unprecedented climate impacts on human life, infrastructure, and ecosystems. Here, we show that extreme heat in several regions globally is increasing significantly and faster in magnitude than what state- of- the- art climate models have predicted under present warming even after accounting for their regional summer background warming. Across all global...
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作者：Nagy, M. Aurel; Price, Spencer; Wang, Kristina; Gill, Stanley; Ren, Erika; Jayne, Lorna; Pajak, Victoria; Deighan, Sarah; Liu, Bin; Lu, Xiaodong; Diallo, Aissatou; Lo, Shih-Ching; Kleiman, Robin; Henderson, Christopher; Suh, Junghae; Griffith, Eric C.; Greenberg, Michael E.; Hrvatin, Sinisa
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Harvard University; Biogen; University of California System; University of California San Francisco; Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT)
摘要：Spinal motor neuron (MN) dysfunction is the cause of a number of clinically significant movement disorders. Despite the recent approval of gene therapeutics targeting these MN- related disorders, there are no viral delivery mechanisms that achieve MN- restricted transgene expression. In this study, chromatin accessibility profiling of genetically defined mouse MNs was used to identify candidate cis- regulatory elements (CREs) capable of driving MN- selective gene expression. Subsequent testing...
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作者：Dertwinkel-Kalt, Markus; Feldhaus, Christoph; Ockenfels, Axel; Sutter, Matthias
作者单位：University of Munster; Max Planck Society; Ruhr University Bochum; University of Cologne; University of Innsbruck; Universita Ca Foscari Venezia
摘要：In response to the disruption of gas supplies from Russia following the invasion of Ukraine in 2022, European politicians and public utilities appealed to citizens and customers to conserve natural gas. Moreover, they strengthened economic incentives for gas conservation. In fact, a substantial amount of natural gas was saved during the winter of 2022/23. This raises the question to what extent this success is attributable to government and corporate means to foster energy conservation in the ...
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作者：Iturralde, Annette B.; Weller, Cory A.; Giovanetti, Simone M.; Sadhu, Meru J.
作者单位：National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); University of Virginia; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
摘要：Delineating a protein's essential and dispensable domains provides critical insight into how it carries out its function. Here, we developed a high- throughput method to synthesize and test the functionality of all possible in- frame and continuous deletions in a gene of interest, enabling rapid and unbiased determination of protein domain importance. Our approach generates precise deletions using a CRISPR library framework that is free from constraints of gRNA target site availability and eff...
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作者：Liu, Yiming; Park, Wooyoung; Yiu, Chun Ki; Huang, Xingcan; Jia, Shengxin; Chen, Yao; Zhang, Hehua; Chen, Hongting; Wu, Pengcheng; Wu, Mengge; Liu, Zhenyu; Gao, Yuyu; Zhu, Kening; Zhao, Zhao; Li, Yuhang; Yokota, Tomoyuki; Someya, Takao; Yu, Xinge
作者单位：City University of Hong Kong; University of Tokyo; City University of Hong Kong; Beihang University; Tianmushan Lab; Liaoning Academy Materials; Beihang University; University of Tokyo; RIKEN; RIKEN; City University of Hong Kong
摘要：Gustation is one of the five innate sensations for humans, distinguishing from vision, auditory, tactile, and olfaction, as which is a close and chemically induced sense. Despite the fact that a handful of gustation display technologies have been developed, the new technologies still pose significant challenges in miniaturization of the overall size for portability, enriching taste options within a limited working area, supporting natural human-device interaction, and achieving precisely contr...
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作者：Hao, He; Yao, Mingdong; Wang, Ying; Zhang, Chenglong; Liu, Zihe; Nielsen, Jens; Shi, Shuobo; Xiao, Wenhai; Yuan, Yingjin
作者单位：Tianjin University; Tianjin University; Tianjin University; Beijing University of Chemical Technology; Chalmers University of Technology; Tianjin University; Tianjin University
摘要：Cell phase engineering can significantly impact protein synthesis and cell size, potentially enhancing the production of lipophilic products. This study investigated the impact of G1 phase extension on resource allocation, metabolic functions, and the unfolded protein response (UPR) in yeast, along with the potential for enhancing the production of lipophilic compounds. In brief, the regulation of the G1 phase was achieved by deleting CLN3 (G1 cyclin) in various yeast strains. This modificatio...
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作者：Majer, Johann M.; Columbus, Simon; Schweinsberg, Martin
作者单位：University of Hildesheim; Massachusetts Institute of Technology (MIT); European School of Management & Technology
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作者：Ravindranathan, Ramya; Somuncu, Ozge; da Costa, Alexandre Andre B. A.; Mukkavalli, Sirisha; Lamarre, Benjamin P.; Nguyen, Huy; Grochala, Carter; Jiao, Yuqing; Liu, Joyce; Kochupurakkal, Bose; Parmar, Kalindi; Shapiro, Geoffrey I.; D'Andrea, Alan D.
作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Poly (ADP- ribose) glycohydrolase (PARG) is a dePARylating enzyme which promotes DNA repair by removal of poly (ADP- ribose) (PAR) from PARylated proteins. Loss or inhibition of PARG results in replication stress and sensitizes cancer cells to DNA- damaging agents. PARG inhibitors are now undergoing clinical development for patients having tumors with homologous recombination deficiency (HRD), such as cancer patients with germline or somatic BRCA1/2- mutations. PARP inhibitors kill BRCA- defic...
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作者：Mehta, Kritika; Yentsch, Henry; Lee, Jungbin; Yook, Yeeun; Lee, Kwan Young; Gao, Tianyu Terry; Tsai, Nien-Pei; Zhang, Kai
