2024

最新文章

• RAD21 promotes oncogenesis and lethal progression of prostate cancer AI翻译
  作者：Su, Xiaofeng A.; Stopsack, Konrad H.; Schmidt, Daniel R.; Ma, Duanduan; Li, Zhe; Scheet, Paul A.; Penney, Kathryn L.; Lotan, Tamara L.; Abida, Wassim; DeArment, Elise G.; Lu, Kate; Janas, Thomas; Hu, Sofia; Vander Heiden, Matthew G.; Loda, Massimo; Boselli, Monica; Amon, Angelika; Mucci, Lorelei A.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Uniformed Services University of the Health Sciences - USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; University of Texas System; UTMD Anderson Cancer Center; Johns Hopkins University; Memorial Sloan Kettering Cancer Center; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Howard Hughes Medical Institute; American Cancer Society
  摘要：Higher levels of aneuploidy, characterized by imbalanced chromosome numbers, are associated with lethal progression in prostate cancer. However, how aneuploidy contributes to prostate cancer aggressiveness remains poorly understood. In this study, we assessed in patients which genes on chromosome 8q, one of the most frequently gained chromosome arms in prostate tumors, were most strongly associated with long- term risk of cancer progression to metastases and death from prostate cancer (lethal ...
• On the role of small estuaries in retaining buoyant particles AI翻译
  作者：Bo, Tong; Ralston, David K.; Geyer, W. Rockwell; McWilliams, James C.
  作者单位：Woods Hole Oceanographic Institution; University of California System; University of California Los Angeles
  摘要：Estuaries, as connectors between land and ocean, have complex interactions of river and tidal flows that affect the transport of buoyant materials like floating plastics, oil spills, organic matter, and larvae. This study investigates surface-trapped buoyant particle transport in estuaries by using idealized and realistic numerical simulations along with a theoretical model. While river discharge and estuarine exchange flow are usually expected to export buoyant particles to the ocean over sub...
• Reducing the uncertainty in estimating soil microbial- derived carbon storage AI翻译
  作者：Hua, Han; Qian, Chao; Xue, Ke; Jorgensen, Raine Georg; Keiluweit, Marco; Liang, Chao; Zhu, Xuefeng; Chen, Ji; Sun, Yishen; Ni, Haowei; Ding, Jixian; Huang, Weigen; Mao, Jingdong; Tan, Rong- Xi; Zhou, Jizhong; Crowther, Thomas W.; Zhou, Zhi-Hua; Zhang, Jiabao; Liang, Yuting
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Nanjing University; Nanjing University; Universitat Kassel; University of Lausanne; Chinese Academy of Sciences; Shenyang Institute of Applied Ecology, CAS; Aarhus University; Aarhus University; Aarhus University; Old Dominion University; University of Oklahoma System; University of Oklahoma - Norman; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Soil organic carbon (SOC) is the largest carbon pool in terrestrial ecosystems and plays a crucial role in mitigating climate change and enhancing soil productivity. Microbial- derived carbon (MDC) is the main component of the persistent SOC pool. However, current formulas used to estimate the proportional contribution of MDC are plagued by uncertainties due to limited sample sizes and the neglect of bacterial group composition effects. Here, we compiled the comprehensive global dataset and em...
• 撤稿声明: Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model AI翻译
  作者：Volmar, Claude-Henry; Sartor, Gregory C.; Rao, Sunil J.; Ricciardi, Natalie R.; Lambert, Guerline; Brothers, Shaun P.; Wahlestedt, Claes
• Decline in carbon emission intensity of global agriculture has stagnated recently AI翻译
  作者：Bai, Zhaohai; Zhang, Nannan; Winiwarter, Wilfried; Luo, Jiafa; Chang, Jinfeng; Smith, Pete; Ledgard, Stewart; Wu, Yan; Hong, Chaopeng; Conchedda, Giulia; Ma, Lin
  作者单位：Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Center for Agricultural Resources Research, Institute of Genetic & Developmental Biology, CAS; International Institute for Applied Systems Analysis (IIASA); University of Zielona Gora; AgResearch - New Zealand; Zhejiang University; University of Aberdeen; Hangzhou City University; Tsinghua Shenzhen International Graduate School; Tsinghua University; Food & Agriculture Organization of the United Nations (FAO); Nanjing University
  摘要：Using global data for around 180 countries and territories and 170 food/feed types primarily derived from FAOSTAT, we have systematically analyzed the changes in greenthe past six decades. We found that, with large spatial heterogeneity, emission intensity decreased by nearly two- thirds from 1961 to 2019, predominantly in the earlier years due to agronomic improvement in productivity. However, in the most recent decade, emission intensity has become stagnant, and in a few countries even showe...
• Elucidating the sustainability of 700 y of Inuvialuit beluga whale hunting in the Mackenzie River Delta, Northwest Territories, Canada AI翻译
  作者：Skovrind, Mikkel; Louis, Marie; Ferguson, Steven H.; Glazov, Dmitry M.; Litovka, Dennis I.; Loseto, Lisa; Meschersky, Ilya G.; Miller, Mariah M.; Petr, Martin; Postma, Lianne; V. Rozhnov, Viatcheslav; Scott, Michael; V. Westbury, Michael; Szpak, Paul; Friesen, T. Max; Lorenzen, Eline D.
  作者单位：University of Copenhagen; Fisheries & Oceans Canada; Russian Academy of Sciences; Saratov Scientific Center of the Russian Academy of Sciences; Severtsov Institute of Ecology & Evolution; University of Manitoba; Trent University; University of Toronto
  摘要：Beluga whales play a critical role in the subsistence economies and cultural heritage of Indigenous communities across the Arctic, yet the effects of Indigenous hunting on beluga whales remain unknown. Here, we integrate paleogenomics, genetic simulations, and stable delta 13C and delta 15N isotope analysis to investigate 700 y of beluga subsistence hunting in the Mackenzie Delta area of northwestern Canada. Genetic identification of the zooarchaeological remains, which is based on radiocarbon...
• R- loop functions in Brca1-associated mammary tumorigenesis AI翻译
  作者：Chiang, Huai - Chin; Qi, Leilei; Mitra, Payal; Huang, Yimeng; Hu, Yanfen; Li, Rong
  作者单位：George Washington University; George Washington University
  摘要：Deleterious accumulation of R- loops, a DNA-RNA hybrid structure, contributes to genome instability. They are associated with BRCA1 mutation- related breast cancer, an estrogen receptor alpha negative (ER alpha-) tumor type originating from luminal progenitor cells. However, a presumed causality of R- loops in tumorigenesis has not been established in vivo. Here, we overexpress mouse Rnaseh1 (Rh1-OE) in vivo to remove accumulated R- loops in Brca1- deficient mouse mammary epithelium (BKO). R- ...
• Propagation of distinct CWD prion strains during peripheral and intracerebral challenges of gene- targeted mice AI翻译
  作者：Defranco, Joseph P.; Bian, Jifeng; Kim, Sehun; Crowell, Jenna; Webster, Bailey K.; Atkinson, Zoe N.; Telling, Glenn C.
  作者单位：United States Department of Agriculture (USDA); USDA Agricultural Research Service; INRAE
  摘要：Since prion diseases result from infection and neurodegeneration of the central nervous system (CNS), experimental characterizations of prion strain properties customarily rely on the outcomes of intracerebral challenges. However, natural transmission of certain prions, including those causing chronic wasting disease (CWD) in elk and deer, depends on propagation in peripheral host compartments prior to CNS infection. Using gene- targeted GtE and GtQ mice, which accurately control cellular elk ...
• Precision- guided tools for malaria control AI翻译
  作者：Rasgon, Jason L.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
• Plasticity of the selectivity filter is essential for permeation in lysosomal TPC2 channels AI翻译
  作者：Zaki, Afroditi-Mario; Cinaroglu, Sueleyman Selim; Rahman, Taufiq; Patel, Sandip; Biggin, Philip C.
  作者单位：University of Oxford; University of Cambridge; University of London; University College London; Ege University
  摘要：Two- pore channels are pathophysiologically important Na+- and Ca2+- permeable channels expressed in lysosomes and other acidic organelles. Unlike most other ion channels, their permeability is malleable and ligand- tuned such that when gated by the signaling lipid PI(3,5)P2, they are more Na+- selective than when gated by the Ca2+ mobilizing messenger nicotinic acid adenine dinucleotide phosphate. However, the structural basis that underlies such plasticity and single- channel behavior more g...