2024

最新文章

• Nutrient colimitation is a quantitative, dynamic property of microbial populations AI翻译
  作者：Held, Noelle A.; Krishna, Aswin; Crippa, Donat; Battaje, Rachana Rao; Devaux, Alexander J.; Dragan, Anastasia; Manhart, Michael
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Southern California; Swiss Federal Institutes of Technology Domain; ETH Zurich; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences
  摘要：Resource availability dictates how fast and how much microbial populations grow. Quantifying the relationship between microbial growth and resource concentrations makes it possible to promote, inhibit, and predict microbial activity. Microbes require many resources, including macronutrients (e.g., carbon and nitrogen), micronutrients (e.g., metals), and complex nutrients like vitamins and amino acids. When multiple resources are scarce, as frequently occurs in nature, microbes may experience r...
• Synthesis of evidence yields high social cost of carbon due to structural model variation and uncertainties AI翻译
  作者：Moore, Frances C.; Drupp, Moritz A.; Rising, James; Dietz, Simon; Rudik, Ivan; Wagner, Gernot
  作者单位：University of California System; University of California Davis; University of Hamburg; University of Hamburg; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Gothenburg; University of Delaware; University of London; London School Economics & Political Science; Cornell University; Columbia University
  摘要：Estimating the cost to society from a ton of CO2-termed the social cost of carbon (SCC)-requires connecting a model of the climate system with a representation of the economic and social effects of changes in climate, and the aggregation of diverse, uncertain impacts across both time and space. A growing literature has examined the effect of fundamental structural elements of the models supporting SCC calculations. This work has accumulated in a piecemeal fashion, leaving their relative import...
• Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1 AI翻译
  作者：Perry, Carmen; Gerhards, Nora Merete; Francica, Paola; Rottenberg, Sven; Nussenzweig, Andre
  作者单位：University of Bern; University of Bern
  摘要：Taxanes are frequently used anticancer drugs known to kill tumor cells by inducing mitotic aberrations and segregation defects. A defining feature of specific cancers, notably triple- negative breast cancer (TNBC) and particularly those deficient in BRCA1, is chromosomal instability (CIN). Here, we focused on understanding the mechanisms of docetaxel- induced cytotoxicity, especially in the context of BRCA1- deficient TNBC. Using functional genetic screens in CIN+ cells, we identified genes th...
• Ventilation does not affect close- range transmission of influenza virus in a ferret playpen setup (vol 121, e2322660121, 2024) AI翻译
  作者：Rockey, Nicole C.; Le Sage, Valerie; Shephard, Meredith; Vargas-Maldonado, Nahara; Vu, Michelle N.; Brown, Cambria A.; Patel, Krishna; French, Andrea J.; Merrbach, Grace A.; Walter, Sydney; Ferreri, Lucas M.; Holmes, Katie E.; VanInsberghe, David; Clack, Herek L.; Prussin, Aaron J.; Lowen, Anice C.; Marr, Linsey C.; Lakdawala, Seema S.
• Origin of fast charging in solid- state batteries revealed by Cryo-transmission X- ray microscopy AI翻译
  作者：Liu, Jiaxuan; Song, Yajie; Liu, Qingsong; Zhao, Wei; An, Hanwen; Zhou, Zinan; Xu, Zihan; Li, Menglu; Deng, Biao; Wang, Jiajun
  作者单位：Harbin Institute of Technology; Harbin Institute of Technology; Harbin Institute of Technology; Harbin Institute of Technology; Chinese Academy of Sciences; Shanghai Institute of Applied Physics, CAS
  摘要：The interface issue poses a limitation on the fast charging of solid- state batteries (SSBs), with the high- impedance non- Faraday electric field serving as a pivotal factor. However, the mechanism of fast- charging capability degradation triggered by the dynamic evolution of non- Faraday electric fields remains unclear due to the lack of particle- scale nondestructive detection techniques. Here, we dissect the generation and elimination processes of non- Faradaic electric field in segments u...
• Ion permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants AI翻译
  作者：Mkrtchyan, Liana; Sahakyan, Harutyun; Eldstrom, Jodene; Karapetyan, Tatev; Abrahamyan, Astghik; Nazaryan, Karen; Schwarz, Juergen R.; Kneussel, Matthias; Fedida, David; Vardanyan, Vitya
  作者单位：University of British Columbia; University of Hamburg; University Medical Center Hamburg-Eppendorf; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM)
  摘要：KCNQ1 potassium channels play a pivotal role in the physiology and pathophysiology of several human excitable and epithelial tissues. The latest cryo- electron microscopy (cryo- EM) structures provide unique insights into channel function and pharmacology, opening avenues for different therapeutic strategies against human diseases associated with KCNQ1 mutations. However, these structures also raise fundamental questions about the mechanisms of ion permeation. Cryo- EM structures thought to re...
• Long-range Atoh1 enhancers maintain competency for hair cell regeneration in the inner ear AI翻译
  作者：Shi, Tuo; Kim, Yeeun; Llamas, Juan; Wang, Xizi; Fabian, Peter; Lozito, Thomas P.; Segil, Neil; Gnedeva, Ksenia; Crump, J. Gage
  作者单位：University of Southern California; University of Southern California
  摘要：During tissue regeneration, lineage- related cells can switch their fate to replace missing cells. This cell plasticity is particularly prominent in more regenerative vertebrates such as zebrafish, yet the molecular basis by which cells transdifferentiate into another cell type upon injury remains unclear. Here, we investigate the epigenetic basis of regenerative transdifferentiation in the inner ear, where supporting cells (SCs) generate mechanosensory hair cells (HCs) upon damage. By compari...
• Patterns of linguistic simplification on social media platforms over time AI翻译
  作者：Di Marco, N.; Loru, Edoardo; Bonetti, Anita; Serra, Alessandra Olga Grazia; Cinelli, Matteo; Quattrociocchi, Walter; Fiske, Susan
  作者单位：Sapienza University Rome; Sapienza University Rome; Tuscia University
  摘要：Understanding the impact of digital platforms on user behavior presents foundational challenges, including issues related to polarization, misinformation dynamics, and variation in news consumption. Comparative analyses across platforms and over different years can provide critical insights into these phenomena. This study investigates the linguistic characteristics of user comments over 34 y, focusing on their complexity and temporal shifts. Using a dataset of approximately 300 million Englis...
• Shielding the Hägg carbide by a graphene layer for ultrahigh carbon efficiency during syngas conversion AI翻译
  作者：Zhang, Xueqing; Li, Zhe; Sun, Wei; Zhang, Yuhua; Li, Jinlin; Wang, Li
  作者单位：South Central Minzu University
  摘要：Fischer-Tropsch synthesis represents a key endeavor aimed at converting nonpetroleum carbon resources into clean fuels and valuable chemicals. However, the current state-of-the-art industrial FTS employing Fe-based catalysts is still challenged by the low carbon efficiency (<50%), mainly attributed to the prominent formation of CO2 and CH4 resulting from the nonregulated side water gas shift reaction. Herein, we describe a shielding strategy involving the encapsulation of the active H & auml;g...
• Constitutive opening of the Kv7.2 pore activation gate causes KCNQ2- developmental encephalopathy AI翻译
  作者：Nappi, Mario; Alberini, Giulio; Berselli, Alessandro; Roscioni, Agnese; Soldovieri, Maria Virginia; Servettini, Ilenio; Barrese, Vincenzo; Weckhuysen, Sarah; Chiu, Ting-Gee Annie; Scheffer, Ingrid E.; Benfenati, Fabio; Maragliano, Luca; Miceli, Francesco; Taglialatela, Maurizio
  作者单位：University of Naples Federico II; Istituto Italiano di Tecnologia - IIT; Marche Polytechnic University; University of Molise; Flanders Institute for Biotechnology (VIB); University of Antwerp; University of Antwerp; University of Antwerp; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; University of Melbourne; University of Melbourne; Florey Institute of Neuroscience & Mental Health; University of Melbourne; Murdoch Children's Research Institute; Royal Children's Hospital Melbourne
  摘要：Pathogenic variants in KCNQ2 encoding Kv7.2 voltage- gated potassium channel subunits cause developmental encephalopathies ( KCNQ2- encephalopathies), both with and without epilepsy. We herein describe the clinical, in vitro, and in silico features of two encephalopathy- causing variants (A317T, L318V) in Kv7.2 affecting two consecutive residues in the S6 activation gate that undergoes large structural rearrangements during pore opening; the disease- causing A356T variant in KCNQ3, paralogous ...