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作者：Schelinski, Stefanie; Kauffmann, Louise; Tabas, Alejandro; Mueller-Axt, Christa; von Kriegstein, Katharina
作者单位：Technische Universitat Dresden; Max Planck Society; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Universite Savoie Mont Blanc; Basque Foundation for Science
摘要：The long- standing hypothesis that autism is linked to changes in the visual magnocellular system of the human brain has never been directly examined due to technological to investigate this hypothesis within the visual sensory thalamus (lateral geniculate nucleus, LGN). The LGN is a crucial component of the primary visual pathway. It is particularly suited to investigate the magnocellular visual system, because within the LGN, the magnocellular (mLGN) uniquely segregates from the parvocellula...
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作者：Contreras, Lydia M.; Belfort, Marlene
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; State University of New York (SUNY) System; University at Albany, SUNY; State University of New York (SUNY) System; University at Albany, SUNY
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作者：Kim, Yeon Soo; Kimball, Scot R.; Piskounova, Elena; Begley, Thomas J.; Hempel, Nadine
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Cornell University; Weill Cornell Medicine; State University of New York (SUNY) System; University at Albany, SUNY; State University of New York (SUNY) System; University at Albany, SUNY; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：From tumorigenesis to advanced metastatic stages, tumor cells encounter stress, ranging from limited nutrient and oxygen supply within the tumor microenvironment to extrinsic and intrinsic oxidative stress. Thus, tumor cells seize regulatory pathways to rapidly adapt to distinct physiologic conditions to promote cellular survival, including manipulation of mRNA translation. While it is now well established that metastatic tumor cells must up- regulate their antioxidant capacity to effectively ...
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作者：Robson, Harry K.; Hausmann, Niklas; Laurie, Eva M.; Astrup, Peter Moe; Povlsen, Karen; Sorensen, Soren A.; Andersen, Soren H.; Milner, Nicky
作者单位：University of York - UK
摘要：Oysters (Ostreidae) play a pivotal role in the health and productivity of marine ecosystems. Their unique ability to filter water, provide habitat, and contribute to nutrient cycling has remained underused in many parts of Europe following the destruction of vast oyster beds in the 19th and 20th centuries. The burgeoning field of oyster restoration for aquaculture has recognized the potential of these bivalves in promoting ecosystem resilience and enhancing biodiversity. Restoring oysters to p...
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作者：Wu, Min; Ma, Tieju; Zhu, Yan; Ren, Hongtao; Fu, Lu
作者单位：East China University of Science & Technology; Shanghai Jiao Tong University; International Institute for Applied Systems Analysis (IIASA); Institute of Information on Traditional Chinese Medicine, CACMS; China Academy of Chinese Medical Sciences; China Academy of Chinese Medical Sciences
摘要：It has been widely recognized that technologies evolve with recombinant inventions. However, it remains unknown whether technologies developed using different approaches would exhibit different features during evolution. In particular, would technologies developed mainly based on accumulated experience in practices-formulas of traditional Chinese medicine (TCM) are typical examples of such technologies-have similar evolution features found in modern technologies? This study applied network sci...
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作者：Georgiev, Dimitar; Fernandez-Galiana, Alvaro; Pedersen, Simon Vilms; Papadopoulos, Georgios; Xie, Ruoxiao; Stevens, Molly M.; Barahona, Mauricio
作者单位：Imperial College London; Imperial College London; Imperial College London; Imperial College London; Imperial College London; University of Oxford; University of Oxford; University of Oxford; Imperial College London
摘要：Raman spectroscopy is widely used across scientific domains to characterize the chemical composition of samples in a nondestructive, label-free manner. Many applications entail the unmixing of signals from mixtures of molecular species to identify the individual components present and their proportions, yet conventional methods for chemometrics often struggle with complex mixture scenarios encountered in practice. Here, we develop hyperspectral unmixing algorithms based on autoencoder neural n...
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作者：Kogan, Valeria; Molodtsov, Ivan; Fleyshman, Daria I.; V. Leontieva, Olga; Koman, Igor E.; V. Gudkov, Andrei
作者单位：Ariel University; Roswell Park Comprehensive Cancer Center
摘要：Approximately half of mammalian genomes are occupied by retrotransposons, highly repetitive interspersed genetic elements expanded through the mechanism of reverse transcription. The evolution of this retrobiome involved a series of explosive amplifications, presumably associated with high mutation rates, interspersed with periods of silencing. A by- product of retrotransposon activity is the formation of processed pseuWe examined the proportion of PPGs with varying degrees of deviation from t...
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作者：Zhou, Xiaoxue; Weng, Shannon Y.; Bell, Stephen P.; Amon, Angelika
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; New York University
摘要：In the budding yeast Saccharomyces cerevisiae, exit from mitosis is coupled to spindle position to ensure successful genome partitioning between mother and daughter cells. This coupling occurs through a GTPase signaling cascade known as the mitotic exit network (MEN). The MEN senses spindle position via a Ras- like GTPase Tem1 which localizes to the spindle pole bodies (SPBs, yeast equivalent of centrosomes) during anaphase and signals to its effector protein kinase Cdc15. How Tem1 couples the...
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作者：Bassi, Marlon I. E.; Staude, Ingmar R.
作者单位：Leipzig University; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv)
摘要：The loss ofwild plant populations is often assumed to lead to coextinctions, particularly among specialized insects. Despite global declines in both terrestrial insects and plants, the relationship between these trends remains elusive. Here, we address this gap by analyzing the relationship between population trends of insects and their host plants in Germany, encompassing over 150,000 interactions among 3,429 plant and 2,239 insect species, including both pollinators (bees and hoverflies) and...
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作者：Jiang, Li; Qi, Xuxin; Lai, Minshan; Zhou, Jiahao; Yuan, Meng; You, Jieqiong; Liu, Qiang; Pan, Jinchang; Zhao, Luyao; Ying, Meidan; Ji, Junfang; Li, Ke; Zhang, Yan; Pan, Weiwei; He, Qiaojun; Yang, Bo; Cao, Ji
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Westlake University; Zhejiang University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Liangzhu Laboratory; Zhejiang University; Zhejiang University; Jiaxing University; Hangzhou City University
摘要：The dysfunction of the ubiquitin-proteasome system (UPS) facilitates the malignant progression of hepatocellular carcinoma (HCC). While targeting the UPS for HCC therapy has been proposed, identifying effective targets has been challenging. In this study, we conducted a focused screen of siRNA libraries targeting UPS- related WD40 repeat (WDR) proteins and found that silencing WDR20, a deubiquitinating enzyme activating factor, selectively inhibited the proliferation of HCC cells without affec...
