2024

最新文章

• Internal catalysis significantly promotes the bond exchange of covalent adaptable polyurethane networks AI翻译
  作者：Huang, Hongfei; Sun, Wei; Sun, Lijie; Zhang, Luzhi; Wang, Yang; Zhang, Youwei; Gu, Shijia; You, Zhengwei; Zhu, Meifang; Aizenberg, Joanna
  作者单位：Donghua University
  摘要：Self- healing covalent adaptable networks (CANs) are not only of fundamental interest but also of practical importance for achieving carbon neutrality and sustainable development. However, there is a trade- off between the mobility and cross- linking structure of CANs, making it challenging to develop CANs with excellent mechanical properties and high self- healing efficiency. Here, we report the utilization of a highly dynamic four- arm cross- linking unit with an internally catalyzed oxime- ...
• Insights into the interaction between UGGT, the gatekeeper of folding in the ER, and its partner, the selenoprotein SEP15 AI翻译
  作者：V. Williams, Robert; Guay, Kevin P.; Lesk, Owen A. Hurlbut; Clerico, Eugenia M.; Hebert, Daniel N.; Gierasch, Lila M.
  作者单位：University of Massachusetts System; University of Massachusetts Amherst; University of Massachusetts System; University of Massachusetts Amherst
  摘要：The enzyme UDP- glucose: glycoprotein glucosyltransferase (UGGT) is the gatekeeper of protein folding within the endoplasmic reticulum (ER). One- third of the human proteome traverses the ER where folding and maturation are facilitated by a complex protein homeostasis network. Both glycan modifications and disulfide bonds are of key importance in the maturation of these ER proteins. The actions of UGGT are intimately linked to the glycan code for folding and maturation of secretory proteins in...
• Improvement of a mouse infection model to capture Pseudomonas aeruginosa chronic physiology in cystic fibrosis AI翻译
  作者：Duncan, Rebecca P.; Moustafa, Dina A.; Lewin, Gina R.; Diggle, Frances L.; Bomberger, Jennifer M.; Whiteley, Marvin; Goldberg, Joanna B.
  作者单位：Emory University; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Centers for Disease Control & Prevention - USA; University System of Ohio; Case Western Reserve University; Dartmouth College
  摘要：Laboratory models are central to microbiology research, advancing the understanding of bacterial physiology by mimicking natural environments, from soil to the human micro- biome. When studying host-bacteria interactions, animal models enable investigators to examine bacterial dynamics associated with a host, and in the case of human infections, animal models are necessary to translate basic research into clinical treatments. Efforts toward improving animal infection models are typically based...
• Multimodal neuro- nanotechnology: Challenging in glioblastoma therapy (vol 121, e2306973121, 2024) AI翻译
  作者：Kudruk, Sergej; Forsyth, Connor M.; Dion, Michelle Z.; Orbeck, Jenny K. Hedlund; Luo, Jingqin; Klein, Robyn S.; Kim, Albert H.; Heimberger, Amy B.; Mirkin, Chad A.; Stegh, Alexander H.; Artzi, Natalie
• Matrix stiffness- dependent regulation of immunomodulatory genes in human MSCs is associated with the lncRNA CYTOR AI翻译
  作者：Lim, Justin J.; Vining, Kyle H.; Mooney, David J.; Blencowe, Benjamin J.
  作者单位：University of Toronto; University of Toronto; University of Pennsylvania; University of Pennsylvania; Harvard University; Harvard University
  摘要：Cell-matrix interactions in 3D environments significantly differ from those in 2D cultures. As such, mechanisms of mechanotransduction in 2D cultures are not necessarily applicable to cell- encapsulating hydrogels that resemble features of tissue architecture. Accordingly, the characterization of molecular pathways in 3D matrices is expected to uncover insights into how cells respond to their mechanical environment in physiological contexts, and potentially also inform hydrogel-based strategie...
• Central role of brain regulatory T cells in the inflammatory cascade in Alzheimer's disease AI翻译
  作者：Plascencia-Villa, German; Castellani, Rudolph J.; Perry, George
  作者单位：University of Texas System; University of Texas at San Antonio; Northwestern University; Feinberg School of Medicine
• The physical soldier caste of an invasive, human-infecting flatworm is morphologically extreme and obligately sterile AI翻译
  作者：Metz, Daniel C. G.; Hechinger, Ryan F.
  作者单位：University of California System; University of California San Diego; University of Nebraska System; University of Nebraska Lincoln
  摘要：We show that the globally invasive, human- infectious flatworm, Haplorchis pumilio, possesses the most physically specialized soldier caste yet documented in trematodes. Soldiers occur in colonies infecting the first intermediate host, the freshwater snail Melanoides tuberculata, and are readily distinguishable from immature and mature reproductive worms. Soldiers possess a pharynx five times absolutely larger than those of immature and mature reproductives, lack a germinal mass, and have a di...
• Transcriptional drift in aging cells: A global decontroller AI翻译
  作者：Matsuzaki, Tyler; Weistuch, Corey; de Graff, Adam; Dill, Ken A.; Balazsi, Gabor
  作者单位：State University of New York (SUNY) System; Stony Brook University; Memorial Sloan Kettering Cancer Center; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University
  摘要：As cells age, they undergo a remarkable global change: In transcriptional drift, hundreds of genes become overexpressed while hundreds of others become underexpressed. Using archetype modeling and Gene Ontology analysis on data from aging Caenorhabditis elegans worms, we find that the up-regulated genes code for sensory proteins upstream of stress responses and down-regulated genes are growth- and metabolism-related. We observe similar trends within human fibroblasts, suggesting that this proc...
• Drosophila neuronal Glucose-6-Phosphatase is a modulator of neuropeptide release that regulates muscle glycogen stores via FMRFamide signaling AI翻译
  作者：Miyamoto, Tetsuya; Hedjazi, Sheida; Miyamoto, Chika; Amrein, Hubert
  作者单位：Texas A&M University System; Texas A&M University College Station
  摘要：Neuropeptides (NPs) and their cognate receptors are critical effectors of diverse physiological processes and behaviors. We recently reported of a noncanonical function of the Drosophila Glucose- 6- Phosphatase (G6P) gene in a subset of neurosecretory cells in the central nervous system that governs systemic glucose homeostasis in food- deprived flies. Here, we show that G6P- expressing neurons define six groups of NP- secreting cells, four in the brain and two in the thoracic ganglion. Using ...
• An atlas of the tomato epigenome reveals that KRYPTONITE shapes TAD- like boundaries through the control of H3K9ac distribution AI翻译
  作者：An, Jing; Chaouche, Rim Brik; Bistrain, Leonardo I. Pereyra-; Zalzale, Hugo; Wang, Qingyi; Huang, Ying; He, Xiaoning; Lopes, Chloe Dias; Sanchez, Javier Antunez-; Bergounioux, Catherine; Boulogne, Claire; Dupas, Cynthia; Gillet, Cynthia; Perez-Perez, Jose Manuel; Mathieu, Olivier; Bouche, Nicolas; Fragkostefanakis, Sotirios; Zhang, Yijing; Zheng, Shaojian; Crespi, Martin; Mahfouz, Magdy M.; Ariel, Federico; Marcos, Jose Gutierrez-; Raynaud, Cecile; Latrasse, David; Benhamed, Moussa
  作者单位：Universite Paris Cite; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); INRAE; Universite Paris Saclay; Universite Paris Cite; University of Warwick; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universidad Miguel Hernandez de Elche; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Clermont Auvergne (UCA); AgroParisTech; INRAE; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Goethe University Frankfurt; Fudan University; Zhejiang University; King Abdullah University of Science & Technology; National University of the Littoral; Institut Universitaire de France
  摘要：In recent years, the exploration of genome three- dimensional (3D) conformation has yielded profound insights into the regulation of gene expression and cellular functions in both animals and plants. While animals exhibit a characteristic genome topology defined by topologically associating domains (TADs), plants display similar features with a more diverse conformation across species. Employing advanced high- throughput sequencing and microscopy techniques, we investigated the landscape of 26...