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作者：Szathmary, Eoers
作者单位：HUN-REN; HUN-REN Centre for Ecological Research
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作者：Hideshima, Teru; Qi, Jun; Paranal, Ronald M.; Tang, Weiping; Greenberg, Edward; West, Nathan; Colling, Meaghan E.; Estiu, Guillermina; Mazitschek, Ralph; Perry, Jennifer A.; Ohguchi, Hiroto; Cottini, Francesca; Mimura, Naoya; Gorgun, Gullu; Tai, Yu-Tzu; Richardson, Paul G.; Carrasco, Ruben D.; Wiest, Olaf; Schreiber, Stuart L.; Anderson, Kenneth C.; Bradner, James E.
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作者：Waite, Kenrick A.; Vontz, Gabrielle; Lee, Stella Y.; Roelofs, Jeroen
作者单位：Louisiana State University System; Louisiana State University Health Sciences Center New Orleans; University of Kansas; University of Kansas Medical Center
摘要：Stress conditions can cause the relocalization of proteasomes to condensates in yeast and mammalian cells. The interactions that facilitate the formation of proteasome condensates, however, are unclear. Here, we show that the formation of proteasome condensates in yeast depends on ubiquitin chains together with the proteasome shuttle factors Rad23 and Dsk2. These shuttle factors colocalize to these condensates. Strains deleted for the third shuttle factor gene, DDI1, show proteasome condensate...
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作者：Dutta, Debdeep; Kanca, Oguz; Shridharan, Rishi V.; Marcogliese, Paul C.; Steger, Benjamin; Morimoto, Marie; Frost, F. Graeme; Macnamara, Ellen; Wangler, Michael F.; Yamamoto, Shinya; Jenny, Andreas; Adams, David; Malicdan, May C.; Bellen, Hugo J.
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva University; University of Manitoba
摘要：Nascent proteins destined for the cell membrane and the secretory pathway are targeted to the endoplasmic reticulum (ER) either posttranslationally or cotranslationally. The signal- independent pathway, containing the protein TMEM208, is one of three pathways that facilitates the translocation of nascent proteins into the ER. The in vivo function of this protein is ill characterized in multicellular organisms. Here, we generated a CRISPR- induced null allele of the fruit fly ortholog CG8320/Tm...
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作者：Mu, Zheng; Lai, Qing; Xie, Yu
作者单位：National University of Singapore; State University System of Florida; Florida International University; Princeton University; Peking University
摘要：While modern family- related ideas and behaviors have become more widely accepted in contemporary China, Chinese Muslim minorities continue to hold on to traditional religious practices. Surprisingly, data from our survey conducted in Gansu province in China's northwestern borderlands reveal that Muslims of the Hui and Dongxiang ethnicities reported much higher rates of cohabitation experience than the secular majority Han. Based on follow-up qualitative interviews, we found the answer to lie ...
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作者：Zheng, Hui; Choi, Yoonyoung
作者单位：University System of Ohio; Ohio State University; University of Hong Kong
摘要：Despite the significant scientific advancement in deciphering the deaths of despair narrative, most relevant studies have focused on drug- , alcohol- , and suicide- related (DAS) deaths. This study directly investigated despair as a determinant of death and the temporal variation and racial heterogeneity among individuals. We used psychological distress (PD) as a proxy for despair and drew data from the US National Health Interview Survey- Linked Mortality Files 1997 to 2014, CDC (Centers for ...
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作者：Kelly, Abigail G.; Wang, Weicang; Rothenberger, Eva; Yang, Jun; Gilligan, Molly M.; Kipper, Franciele C.; Attaya, Ahmed; Gartung, Allison; Hwang, Sung Hee; Gillespie, Michael J.; Bayer, Rachel L.; Quinlivan, Katherine M.; Torres, Kimberly L.; Huang, Sui; Mitsiades, Nicholas; Yang, Haixia; Hammock, Bruce D.; Panigrahy, Dipak
作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; University of California System; University of California Davis; University of California System; University of California Davis; Purdue University System; Purdue University; Institute for Systems Biology (ISB); University of California System; University of California Davis; China Agricultural University
摘要：Cancer therapy, including immunotherapy, is inherently limited by chronic inflammationinduced tumorigenesis and toxicity within the tumor microenvironment. Thus, stimulating the resolution of inflammation may enhance immunotherapy and improve the toxicity of immune checkpoint inhibition (ICI). As epoxy - fatty acids (EpFAs) are degraded by the enzyme soluble epoxide hydrolase (sEH), the inhibition of sEH increases endogenous EpFA levels to promote the resolution of cancer- associated inflammat...
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作者：Kline, Sabrina N.; Orlando, Nicholas A.; Lee, Alex J.; Wu, Meng - Jen; Zhang, Jing; Youn, Christine; Feller, Laine E.; Pontaza, Cristina; Dikeman, Dustin; Limjunyawong, Nathachit; Williams, Kaitlin L.; Wang, Yu; Cihakova, Daniela; Jacobsen, Elizabeth A.; Durum, Scott K.; Garza, Luis A.; Dong, Xinzhong; Archer, Nathan K.
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Mahidol University; Johns Hopkins University; Johns Hopkins Medicine; Mayo Clinic; Mayo Clinic Phoenix; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Howard Hughes Medical Institute; Johns Hopkins University; Johns Hopkins University
摘要：Staphylococcus aureus skin colonization and eosinophil infiltration are associated with many inflammatory skin disorders, including atopic dermatitis, bullous pemphigoid, Netherton's syndrome, and prurigo nodularis. However, whether there is a relationship between S. aureus and eosinophils and how this interaction influences skin inflammation is largely undefined. We show in a preclinical mouse model that S. aureus epicutaneous exposure induced eosinophil- recruiting chemokines and eosinophil ...
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作者：Zhang, Yue; Bharathi, Vanthana; Dokoshi, Tatsuya; de Anda, Jaime; Ursery, Lauryn Tumey; Kulkarni, Nikhil N.; Nakamura, Yoshiyuki; Chen, Jonathan; Luo, Elizabeth W. C.; Wang, Lamei; Xu, Hua; Coady, Alison; Zurich, Raymond; Lee, Michelle W.; Matsui, Tsutomu; Lee, Hongkyu; Chan, Liana C.; Schepmoes, Athena A.; Lipton, Mary S.; Zhao, Rui; Adkins, Joshua N.; Clair, Geremy C.; Thurlow, Lance R.; Schisler, Jonathan C.; Wolfgang, Matthew C.; Hagan, Robert S.; Yeaman, Michael R.; Weiss, Thomas M.; Chen, Xinhua; Li, Melody M. H.; Nizet, Victor; Antoniak, Silvio; Mackman, Nigel; Gallo, Richard L.; Wong, Gerard C. L.
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Westlake University; University of North Carolina; University of North Carolina Chapel Hill; University of California System; University of California San Diego; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; University of California System; University of California San Diego; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; United States Department of Energy (DOE); Pacific Northwest National Laboratory; United States Department of Energy (DOE); Pacific Northwest National Laboratory; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
摘要：It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS- CoV- 2) infection leads to the strong but ineffective inflammatory response that characterizes severe Coronavirus disease 2019 (COVID- 19), with amplified immune activation in diverse cell types, including cells without angiotensin- converting enzyme 2 receptors necessary for infection. Proteolytic degradation of SARS- CoV- 2 virions is a milestone in host viral clearance, but the impact of remnant viral peptide fragments...
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作者：McMonigal, Kay
作者单位：University of Alaska System; University of Alaska Fairbanks
