2024

最新文章

• Design principles of heterointerfacial redox chemistry for highly reversible lithium metal anode AI翻译
  作者：Lin, Liang; Li, Jiantao; Zhang, Yinggan; Zheng, Hongfei; Huang, Youzhang; Zhang, Chengkun; Sa, Baisheng; Wang, Laisen; Lin, Jie; Peng, Dong-Liang; Lu, Jun; Amine, Khalil; Xie, Qingshui
  作者单位：Xiamen University; United States Department of Energy (DOE); Argonne National Laboratory; Zhejiang University; Fuzhou University; Xiamen University
  摘要：High electrochemical reversibility is required for the application of high- energy- density lithium (Li) metal batteries; however, inactive Li formation and SEI (solid electrolyte interface)- instability- induced electrolyte consumption cause low Coulombic efficiency (CE). The prior interfacial chemical designs in terms of alloying kinetics have been used to enhance the CE of Li metal anode; however, the role of its redox chemistry at heterointerfaces remains a mystery. Herein, the relationshi...
• Diamond spins making waves again AI翻译
  作者：Burkard, Guido
  作者单位：University of Konstanz
• Precise coordination of high-loading Fe single atoms with sulfur boosts selective generation of nonradicals AI翻译
  作者：Jiang, Xunheng; Zhou, Binghui; Yang, Weijie; Chen, Jiayi; Miao, Chen; Guo, Zhongyuan; Li, Hao; Hou, Yang; Xu, Xinhua; Zhu, Lizhong; Lin, Daohui; Xu, Jiang
  作者单位：Zhejiang University; North China Electric Power University; Zhejiang University; Tohoku University; Zhejiang University
  摘要：Nonradicals are effective in selectively degrading electron-rich organic contaminants, which unfortunately suffer from unsatisfactory yield and uncontrollable composition due to the competitive generation of radicals. Herein, we precisely construct a local microenvironment of the carbon nitride-supported high-loading (similar to 9 wt.%) Fe single-atom catalyst (Fe SAC) with sulfur via a facile supermolecular self-assembly strategy. Short-distance S coordination boosts the peroxymonosulfate (PM...
• Prevention efficacy of the broadly neutralizing antibody VRC01 depends on HIV-1 envelope sequence features AI翻译
  作者：Juraska, Michal; Bai, Hongjun; deCamp, Allan C.; Magaret, Craig A.; Li, Li; Gillespie, Kevin; Carpp, Lindsay N.; Giorgi, Elena E.; Ludwig, James; Molitor, Cindy; Hudson, Aaron; Williamson, Brian D.; Espy, Nicole; Simpkins, Brian; Rudnicki, Erika; Shao, Danica; Rossenkhan, Raabya; Edlefsen, Paul T.; Westfall, Dylan H.; Deng, Wenjie; Chen, Lennie; Zhao, Hong; Bhattacharya, Tanmoy; Pankow, Alec; Murrell, Ben; Yssel, Anna; Matten, David; York, Talita; Beaume, Nicolas; Gwashu-Nyangiwe, Asanda; Ndabambi, Nonkululeko; Thebus, Ruwayhida; Karuna, Shelly T.; Morris, Lynn; Montefiori, David C.; Hural, John A.; Cohen, Myron S.; Corey, Lawrence; Rolland, Morgane; Gilbert, Peter B.; Williamson, Carolyn; Mullins, James I.
  作者单位：Fred Hutchinson Cancer Center; United States Department of Defense; United States Army; Walter Reed Army Institute of Research (WRAIR); Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc; Kaiser Permanente; Claremont Colleges; Pitzer College; University of Washington; University of Washington Seattle; United States Department of Energy (DOE); Los Alamos National Laboratory; Karolinska Institutet; University of Cape Town; University of Cape Town; National Health Laboratory Service; National Institute for Communicable Diseases (NICD); University of Witwatersrand; University of Kwazulu Natal; Duke University; University of North Carolina; University of North Carolina Chapel Hill; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：In the Antibody Mediated Prevention (AMP) trials (HVTN 704/HPTN 085 and HVTN 703/HPTN 081), prevention efficacy (PE) of the monoclonal broadly neutralizing anti-body (bnAb) VRC01 (vs. placebo) against HIV-1 acquisition diagnosis varied according to the HIV-1 Envelope (Env) neutralization sensitivity to VRC01, as measured by 80% inhibitory concentration (IC80). Here, we performed a genotypic sieve analysis, a complementary approach to gaining insight into correlates of protection that assesses ...
• Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells AI翻译
  作者：Urena, Enric; Xu, Bowen; Regan, Jennifer C.; Atilano, Magda L.; Minkley, Lucy J.; Filer, Danny; Lu, Yu-Xuan; Bolukbasi, Ekin; Khericha, Mobina; Alic, Nazif; Partridge, Linda
  作者单位：University of London; University College London; Max Planck Society; University of Edinburgh
  摘要：Pharmacological therapies are promising interventions to slow down aging and reduce multimorbidity in the elderly. Studies in animal models are the first step toward translation of candidate molecules into human therapies, as they aim to elucidate the molecular pathways, cellular mechanisms, and tissue pathologies involved in the anti-aging effects. Trametinib, an allosteric inhibitor of MEK within the Ras/MAPK (Ras/Mitogen-Activated Protein Kinase) pathway and currently used as an anti-cancer...
• Logic- based mechanistic machine learning on high- content images reveals how drugs differentially regulate cardiac fibroblasts AI翻译
  作者：Nelson, Anders R.; Christiansen, Steven L.; Naegle, Kristen M.; Saucerman, Jeffrey J.
  作者单位：University of Virginia; Brigham Young University
  摘要：Fibroblasts are essential regulators of extracellular matrix deposition following cardiac injury. These cells exhibit highly plastic responses in phenotype during fibrosis in response to environmental stimuli. Here, we test whether and how candidate anti- fibrotic drugs differentially regulate measures of cardiac fibroblast phenotype, which may help identify treatments for cardiac fibrosis. We conducted a high- content microscopy screen of human cardiac fibroblasts treated with 13 clinically r...
• Rapid single- particle chemical imaging of nanoplastics by SRS microscopy AI翻译
  作者：Qiana, Naixin; Gaoa, Xin; Lang, Xiaoqi; Deng, Huiping; Bratu, Teodora Maria; Chen, Qixuan; Stapleton, Phoebe; Yan, Beizhan; Min, Wei
  作者单位：Columbia University; Columbia University; Columbia University; Rutgers University System; Rutgers University New Brunswick; Columbia University
  摘要：Plastics are now omnipresent in our daily lives. The existence of microplastics (1 mu m to 5 mm in length) and possibly even nanoplastics (<1 mu m) has recently raised health concerns. In particular, nanoplastics are believed to be more toxic since their smaller size renders them much more amenable, compared to microplastics, to enter the human body. However, detecting nanoplastics imposes tremendous analytical challenges on both the nano- level sensitivity and the plastic- identifying specifi...
• eSoil: A low- power bioelectronic growth scaffold that enhances crop seedling growth AI翻译
  作者：Oikonomou, Vasileios K.; Huerta, Miriam; Sandehn, Alexandra; Dreier, Till; Daguerre, Yohann; Lim, Hyungwoo; Berggren, Magnus; Pavlopoulou, Eleni; Nasholm, Torgny; Bech, Martin; Stavrinidou, Eleni
  作者单位：Linkoping University; Linkoping University; Lund University; Umea University; Swedish University of Agricultural Sciences; Swedish University of Agricultural Sciences; Foundation for Research & Technology - Hellas (FORTH)
  摘要：Active hydroponic substrates that stimulate on demand the plant growth have not been demonstrated so far. Here, we developed the eSoil, a low -power bioelectronic growth scaffold that can provide electrical stimulation to the plants' root system and growth environment in hydroponics settings. eSoil's active material is an organic mixed ionic electronic conductor while its main structural component is cellulose, the most abundant biopolymer. We demonstrate that barley seedlings that are widely ...
• Gut metabolite L- lactate supports Campylobacterjejuni population expansion during acute infection AI翻译
  作者：Sinha, Ritam; LeVeque, Rhiannon M.; Callahan, Sean M.; Chatterjee, Shramana; Stopnisek, Nejc; Kuipel, Matti; Johnson, Jeremiah G.; DiRita, Victor J.
  作者单位：Michigan State University; University of Tennessee System; University of Tennessee Knoxville; Michigan State University; University of Pennsylvania; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute of Ecology (NIOO-KNAW)
  摘要：How the microaerobic pathogen Campylobacter jejuni establishes its niche and expands in the gut lumen during infection is poorly understood. Using 6 -wk -old ferrets as a natural disease model, we examined this aspect of C. jejuni pathogenicity. Unlike mice, which require significant genetic or physiological manipulation to become colonized with C. jejuni, ferrets are readily infected without the need to disarm the immune system or alter the gut microbiota. Disease after C. jejuni infection in...
• The nonlinear mechanics of highly extensible plant epidermal cell walls AI翻译
  作者：Yu, Jingyi; Zhang, Yao; Cosgrove, Daniel J.
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Huazhong University of Science & Technology
  摘要：Plant epidermal cell walls maintain the mechanical integrity of plants and restrict organ growth. Mechanical analyses can give insights into wall structure and are inputs for mechanobiology models of plant growth. To better understand the intrinsic mechan-ics of epidermal cell walls and how they may accommodate large deformations during growth, we analyzed a geometrically simple material, onion epidermal strips consisting of only the outer (periclinal) cell wall, -7 mu m thick. With uniaxial s...