2024

最新文章

• Matriglycan maintains t- tubule structural integrity in cardiac muscle AI翻译
  作者：Hord, Jeffrey M.; Anderson, Mary E.; Prouty, Sally J.; Melton, Shelly; Gastel, Zeita; Zimmerman, Kathy; Weiss, Robert M.; Campbell, Kevin P.
  作者单位：Howard Hughes Medical Institute; University of Iowa; University of Iowa; University of Iowa; University of Iowa; University of Iowa; University of Iowa; US Department of Veterans Affairs; Veterans Health Administration (VHA); Iowa City VA Health Care System; University of Iowa
  摘要：Maintaining the structure of cardiac membranes and membrane organelles is essential for heart function. A critical cardiac membrane organelle is the transverse tubule system (called the t - tubule system) which is an invagination of the surface membrane. unique structural characteristic of the cardiac muscle t - tubule system is the extension of the extracellular matrix (ECM) from the surface membrane into the t - tubule lumen. However, the importance of the ECM extending into the cardiac t - ...
• Did private election administration funding advantage Democrats in 2020? AI翻译
  作者：Lal, Apoorva; Thompson, Daniel M.
  作者单位：University of California System; University of California Los Angeles
  摘要：Private donors contributed more than $350 million to local election officials to support the administration of the 2020 election. Supporters argue these grants were neutral and necessary to maintain normal election operations during the pandemic, while critics worry these grants mostly went to Democratic strongholds and tilted election outcomes. How much did these grants shape the 2020 presidential election? To answer this question, we collect administrative data on private election administra...
• IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota AI翻译
  作者：Roewekamp, Ivo; Maschirow, Laura; Rabes, Anne; Vernengo, Facundo Fiocca; Hamann, Lutz; Heinz, Gitta Anne; Mashreghi, Mir- Farzin; Caesar, Sandra; Milek, Miha; Fonseca, Anna Carolina Fagundes; Wienhold, Sandra - Maria; Nouailles, Geraldine; Yao, Ling; Mousavi, Soraya; Bruder, Dunja; Boehme, Julia D.; Puzianowska-Kuznicka, Monika; Beule, Dieter; Witzenrath, Martin; Loehning, Max; Klose, Christoph S. N.; Heimesaat, Markus M.; Diefenbach, Andreas; Opitz, Bastian
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Leibniz Association; Deutsches Rheuma-Forschungszentrum (DRFZ); Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Otto von Guericke University; Helmholtz Association; Helmholtz-Center for Infection Research; Polish Academy of Sciences; Mossakowski Medical Research Institute of the Polish Academy of Sciences; Centre of Postgraduate Medical Education - Poland; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Leibniz Association; Deutsches Rheuma-Forschungszentrum (DRFZ)
  摘要：IL - 22 plays a critical role in defending against mucosal infections, but how IL - 22 production is regulated is incompletely understood. Here, we show that mice lacking IL - 33 or its receptor ST2 (IL - 1RL1) were more resistant to Streptococcus pneumoniae lung infection than wild - type animals and that single - nucleotide polymorphisms in IL33 and IL1RL1 were associated with pneumococcal pneumonia in humans. The effect of IL - 33 on S. pneumoniae infection was mediated by negative regulati...
• Peripheral preprocessing in Drosophila facilitates odor classification AI翻译
  作者：Puri, Palka; Wu, Shiuan-Tze; Su, Chih-Ying; Aljadeff, Johnatan
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：The mammalian brain implements sophisticated sensory processing algorithms along multilayered (deep) neural networks. Strategies that insects use to meet similar computational demands, while relying on smaller nervous systems with shallow architectures, remain elusive. Using Drosophila as a model, we uncover the algorithmic role of odor preprocessing by a shallow network of compartmentalized olfactory receptor neurons. Each compartment operates as a ratiometric unit for specific odor-mixtures....
• Modeling direct air carbon capture and storage in a 1.5 °C climate future using historical analogs AI翻译
  作者：Edwards, Morgan R.; Thomas, Zachary H.; Nemet, Gregory F.; Rathod, Sagar; Greene, Jenna; Surana, Kavita; Kennedy, Kathleen M.; Fuhrman, Jay; Mcjeon, Haewon C.
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; Vienna University of Economics & Business; University System of Maryland; University of Maryland College Park; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Korea Advanced Institute of Science & Technology (KAIST)
  摘要：Limiting the rise in global temperature to 1.5 degrees C will rely, in part, on technologies to remove CO2 from the atmosphere. However, many carbon dioxide removal (CDR) technologies are in the early stages of development, and there is limited data to inform predictions of their future adoption. Here, we present an approach to model adoption of early-stage technologies such as CDR and apply it to direct air carbon capture and storage (DACCS). Our approach combines empirical data on historical...
• A dopamine mechanism for reward maximization AI翻译
  作者：Schultz, Wolfram
  作者单位：University of Cambridge
  摘要：Individual survival and evolutionary selection require biological organisms to maximize reward. Economic choice theories define the necessary and sufficient conditions, and neuronal signals of decision variables provide mechanistic explanations. Reinforcement learning (RL) formalisms use predictions, actions, and policies to maximize reward. Midbrain dopamine neurons code reward prediction errors (RPE) of subjective reward value suitable for RL. Electrical and optogenetic self - stimulation ex...
• Aire mediates tolerance to insulin through thymic trimming of high- affinity T cell clones AI翻译
  作者：Smith, Jennifer A.; Yuen, Benjamin T. K.; Purtha, Whitney; Balolong, Jared M.; Phipps, Jonah D.; Crawford, Frances; Bluestone, Jeffrey A.; Kappler, John W.; Anderson, Mark S.
  作者单位：University of California System; University of California San Francisco; National Jewish Health; University of California System; University of California San Francisco; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado System; University of Colorado Anschutz Medical Campus
  摘要：Insulin is a central autoantigen in the pathogenesis of T1D, and thymic epithelial cell expression of insulin under the control of the Autoimmune Regulator ( Aire ) is thought to be a key component of maintaining tolerance to insulin. In spite of this general working model, direct detection of this thymic selection on insulinspecific T cells has been somewhat elusive. Here, we used a combination of highly sensitive T cell receptor transgenic models for detecting thymic selection and sorting an...
• Bridging the gap between models based on ordinary, delayed, and fractional differentials equations through integral kernels AI翻译
  作者：Monteiro, Noemi Zeraick; dos Santos, Rodrigo Weber; Mazorche, Sandro Rodrigues
  作者单位：Universidade Federal de Juiz de Fora; Universidade Federal de Juiz de Fora
  摘要：Evolution equations with convolution -type integral operators have a history of study, yet a gap exists in the literature regarding the link between certain convolution kernels and new models, including delayed and fractional differential equations. We demonstrate, starting from the logistic model structure, that classical, delayed, and fractional models are special cases of a framework using a gamma Mittag-Leffler memory kernel. We discuss and classify different types of this general kernel, ...
• Reply to Chadwick et al.: Data, not definitions, drive conclusions AI翻译
  作者：Yan, Zhen; Ferry, James G.
  作者单位：Shandong University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
• SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR- LTD AI翻译
  作者：Lee, Sanghyeon; Kim, Jungho; Ryu, Hyun-Hee; Jang, Hanbyu; Lee, Doeun; Lee, Seungha; Song, Jae-man; Lee, Yong-Seok; Suh, Young Ho
  作者单位：Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU)
  摘要：Posttranslational modifications regulate the properties and abundance of synaptic alpha- amino - 3 - hydroxy - 5 - methyl - 4 - isoxazolepropionic acid (AMPA) receptors that mediate fast excitatory synaptic transmission and synaptic plasticity in the central nervous system. During long - term depression (LTD), protein tyrosine phosphatases (PTPs) dephosphorylate tyrosine residues in the C - terminal tail of AMPA receptor GluA2 subunit, which is essential for GluA2 endocytosis and group I metab...