2024

最新文章

• A CUC1/auxin genetic module links cell polarity to patterned tissue growth and leaf shape diversity in crucifer plants AI翻译
  作者：Hu, Zi-Liang; Wilson-Sanchez, David; Bhatia, Neha; Rast-Somssich, Madlen I.; Wu, Anhui; Vlad, Daniela; McGuire, Liam; Nikolov, Lachezar A.; Laufs, Patrick; Gan, Xiangchao; Laurent, Stefan; Runions, Adam; Tsiantis, Miltos
  作者单位：Max Planck Society; Universite Paris Saclay; INRAE; AgroParisTech; University of Calgary; Heinrich Heine University Dusseldorf; University of Oxford; University of London; King's College London; Indiana University System; Indiana University Bloomington; Nanjing Agricultural University; BioNTech SE
  摘要：How tissue - level information encoded by fields of regulatory gene activity is translated into the patterns of cell polarity and growth that generate the diverse shapes of different species remains poorly understood. Here, we investigate this problem in the case of leaf shape differences between Arabidopsis thaliana , which has simple leaves, and its relative Cardamine hirsuta that has complex leaves divided into leaflets. We show that patterned expression of the transcription factor CUP - SH...
• Denisovan admixture facilitated environmental adaptation in Papua New Guinean populations AI翻译
  作者：Yermakovich, Danat; Andre, Mathilde; Brucato, Nicolas; Kariwiga, Jason; Leavesley, Matthew; Pankratov, Vasili; Mondal, Mayukh; Ricaut, Francois Xavier; Dannemann, Michael
  作者单位：University of Tartu; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Institut de Recherche pour le Developpement (IRD); University of Papua New Guinea; University of Queensland; James Cook University; James Cook University; University of Kiel
  摘要：Neandertals and Denisovans, having inhabited distinct regions in Eurasia and possibly Oceania for over 200,000 y, experienced ample time to adapt to diverse environmental challenges these regions presented. Among present - day human populations, Papua New Guineans (PNG) stand out as one of the few carrying substantial amounts of both Neandertal and Denisovan DNA, a result of past admixture events with these archaic human groups. This study investigates the distribution of introgressed Denisova...
• Teleost Hox code defines regional identities competent for the formation of dorsal and anal fins AI翻译
  作者：Adachi, Urara; Koita, Rina; Seto, Akira; Maeno, Akiteru; Ishizu, Atsuki; Oikawa, Sae; Tani, Taisei; Ishizaka, Mizuki; Yamada, Kazuya; Satoh, Koumi; Nakazawa, Hidemichi; Furudate, Hiroyuki; Kawakami, Koichi; Iwanami, Norimasa; Matsuda, Masaru; Kawamura, Akinori
  作者单位：Saitama University; Utsunomiya University; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Graduate University for Advanced Studies - Japan; Graduate University for Advanced Studies - Japan
  摘要：The dorsal and anal fins can vary widely in position and length along the anterior- posterior axis in teleost fishes. However, the molecular mechanisms underlying the diversification of these fins remain unknown. Here, we used genetic approaches in zebrafish and medaka, in which the relative positions of the dorsal and anal fins are opposite, to demonstrate the crucial role of hox genes in the patterning of the teleost posterior body, including the dorsal and anal fins. By the CRISPR - Cas9 - ...
• Quenching of zonal winds in Jupiter's interior AI翻译
  作者：Christensen, Ulrich R.; Wulff, Paula N.
  作者单位：Max Planck Society
  摘要：Gravity and magnetic field data obtained by the Juno mission show that Jupiter's strong zonal winds extend a few thousand kilometers into the interior, but are quenched above the level where the electrical conductivity becomes significant. Here, we extend a simple linearized model [Christensen et al., Astrophys. J. 890, 61 (2020)] that explains the braking of the jets by the combination of stable stratification and electromagnetic effects. We show that in the inviscid limit, the process is ess...
• Hundreds of antimicrobial peptides create a selective barrier for insect gut symbionts AI翻译
  作者：Lachat, Joy; Lextrait, Gaelle; Jouan, Romain; Boukherissa, Amira; Yokota, Aya; Jang, Seonghan; Ishigami, Kota; Futahashi, Ryo; Cossard, Raynald; Naquin, Delphine; Costache, Vlad; Augusto, Luis; Tissieres, Pierre; Biondi, Emanuele G.; Alunni, Benoit; Timchenko, Tatiana; Ohbayashi, Tsubasa; Kikuchi, Yoshitomo; Mergaert, Peter
  作者单位：Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CEA; National Institute of Advanced Industrial Science & Technology (AIST); Hokkaido University; National Institute of Advanced Industrial Science & Technology (AIST); INRAE; Korea Research Institute of Bioscience & Biotechnology (KRIBB); AgroParisTech; INRAE; Universite Paris Saclay; National Agriculture & Food Research Organization - Japan
  摘要：The spatial organization of gut microbiota is crucial for the functioning of the gut ecosystem, although the mechanisms that organize gut bacterial communities in microhabitats are only partially understood. The gut of the insect Riptortus pedestris has a characteristic microbiota biogeography with a multispecies community in the anterior midgut and a monospecific bacterial population in the posterior midgut. We show that the posterior midgut region produces massively hundreds of specific anti...
• Nationwide law enforcement impact on the pet bird trade in China AI翻译
  作者：Liang, Zhijian; Hu, Sifan; Zhong, Jia; Wei, Qian; Ruan, Xiangdong; Zhang, Li; Lee, Tien Ming; Liu, Yang
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Beijing Normal University
  摘要：Conservation enforcement is a direct strategy to combat illegal wildlife trade in open markets. Yet, its large- scale effectiveness has not been widely assessed due to the lack of extensive market data. Between August 2016 and June 2017, a national coordinated enforcement campaign led by the leading Chinese authority to combat illegal migratory bird trade coincided with the largest- ever pet bird market survey across China by voluntary birdwatchers before and after the enforcement, which serve...
• Facet- switching of rate- determining step on copper in CO2-to- ethylene electroreduction AI翻译
  作者：Zhang, Yu-Cai; Zhang, Xiao-Long; Wu, Zhi-Zheng; Niu, Zhuang-Zhuang; Chi, Li-Ping; Gao, Fei-Yue; Yang, Peng-Peng; Wang, Ye-Hua; Yu, Peng-Cheng; Duanmu, Jing-Wen; Sun, Shu-Ping; Gao, Min-Rui
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：Reduction of carbon dioxide (CO2) by renewable electricity to produce multicarbon chemicals, such as ethylene (C2H4), continues to be a challenge because of insufficient Faradaic efficiency, low production rates, and complex mechanistic pathways. Here, we report that the rate-determining steps (RDS) on common copper (Cu) surfaces diverge in CO2 electroreduction, leading to distinct catalytic performances. Through a combination of experimental and computational studies, we reveal that C & horba...
• Reply to Timonin and Cooley: Varied effects of counterfactuals in 42 countries underscore value of within- country counterfactual AI翻译
  作者：Abrams, Leah R.; Myrskylae, Mikko; Mehta, Neil K.
  作者单位：Tufts University; Max Planck Society; University of Helsinki; University of Texas System; University of Texas Medical Branch Galveston
• Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis AI翻译
  作者：Huang, Ke-Bin; Wang, Feng-Yang; Lu, Yuan; Yang, Liang- Mei; Long, Nian; Wang, Shan - Shan; Xie, Zhiying; Levine, Matthew; Zou, Taotao; Sessler, Jonathan L.; Liang, Hong
  作者单位：Guangxi Normal University; Sun Yat Sen University; University of Texas System; University of Texas Austin
  摘要：Developing anticancer drugs with low side effects is an ongoing challenge. Immunogenic cell death (ICD) has received extensive attention as a potential synergistic modality for cancer immunotherapy. However, only a limited set of drugs or treatment modalities can trigger an ICD response and none of them have cytotoxic selectivity. This provides an incentive to explore strategies that might provide more effective ICD inducers free of adverse side effects. Here, we report a metal- based complex ...
• Phosphorylation of DNA- binding domains of CLOCK-BMAL1 complex for PER- dependent inhibition in circadian clock of mammalian cells AI翻译
  作者：Otobe, Yuta; Jeong, Eui Min; Ito, Shunsuke; Shinohara, Yuta; Kurabayashi, Nobuhiro; Aiba, Atsu; Fukada, Yoshitaka; Kim, Jae Kyoung; Yoshitane, Hikari
  作者单位：University of Tokyo; Tokyo Metropolitan Institute of Medical Science; Institute for Basic Science - Korea (IBS); Korea Advanced Institute of Science & Technology (KAIST); Hokkaido University; Hokkaido University; University of Tokyo
  摘要：In mammals, CLOCK and BMAL1 proteins form a heterodimer that binds to E - box sequences and activates transcription of target genes, including Period ( Per) . Translated PER proteins then bind to the CLOCK-BMAL1 complex to inhibit its transcriptional activity. However, the molecular mechanism and the impact of this PER - dependent inhibition on the circadian clock oscillation remain elusive. We previously identified Ser38 and Ser42 in a DNA - binding domain of CLOCK as phosphorylation sites at...