2024

最新文章

• Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient- sensing pathway AI翻译
  作者：Valenstein, Max L.; V. Lalgudi, Pranav; Gu, Xin; Kedir, Jibril F.; Taylor, Martin S.; Chivukula, Raghu R.; Sabatini, David M.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brown University; Brown University; Brown University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences
  摘要：The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth and metabolism in response to many environmental cues, including nutrients. Amino acids signal to mTORC1 by modulating the guanine nucleotide loading states of the heterodimeric Rag GTPases, which bind and recruit mTORC1 to the lysosomal surface, its site of activation. The Rag GTPases are tethered to the lysosome by the Ragulator complex and regulated by the GATOR1, GATOR2, and KICSTOR multiprotein complexes ...
• Superionic iron hydride shapes ultralow- velocity zones at Earth's core-mantle boundary AI翻译
  作者：Zhang, Yu; Wang, Wenzhong; Li, Yunguo; Wu, Zhongqing
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：Seismological studies have exposed numerous ultralow velocity zones (ULVZs) exhibiting extraordinary physical attributes at Earth's core-mantle boundary, yet their compositions and origins remain controversial. Water-iron reaction can generate unique phases under lowermost- mantle conditions and likely plays a crucial role in forming ULVZs. Through first- principles molecular dynamic simulations with machine learning techniques, we determine that iron hydride, the product of water-iron reactio...
• Zfp697 is an RNA- binding protein that regulates skeletal muscle inflammation and remodeling AI翻译
  作者：Correia, Jorge C.; Jannig, Paulo R.; Gosztyla, Maya L.; Cervenka, Igor; Ducommun, Serge; Praestholm, Stine M.; Dias, Jose M.; Dumont, Kyle D.; Liu, Zhengye; Liang, Qishan; Edsgaerd, Daniel; Emanuelsson, Olof; Gregorevic, Paul; Westerblad, Hakan; Venckunas, Tomas; Brazaitis, Marius; Kamandulis, Sigitas; Lanner, Johanna T.; Teixeira, Ana I.; Yeo, Gene W.; Ruas, Jorge L.
  作者单位：Karolinska Institutet; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; University of California System; University of California San Diego; Royal Institute of Technology; University of Melbourne; Karolinska Institutet; Lithuanian Sports University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Skeletal muscle atrophy is a morbidity and mortality risk factor that happens with disuse, chronic disease, and aging. The tissue remodeling that happens during recovery from atrophy or injury involves changes in different cell types such as muscle fibers, and satellite and immune cells. Here, we show that the previously uncharacterized gene and protein Zfp697 is a damage- induced regulator of muscle remodeling. Zfp697/ ZNF697 expression is transiently elevated during recovery from muscle atro...
• DNA- DISK: Automated end- to- end data storage via enzymatic single- nucleotide DNA synthesis and sequencing on digital microfluidics AI翻译
  作者：Li, Kunjie; Lu, Xiaoyun; Liao, Jiaqi; Chen, Heng; Lin, Wei; Zhao, Yuhan; Tang, Dongbao; Li, Congyu; Tian, Zhenyang; Zhu, Zhi; Jiang, Huifeng; Sun, Jun; Zhang, Huimin; Yang, Chaoyong
  作者单位：Xiamen University; Chinese Academy of Sciences; Tianjin Institute of Industrial Biotechnology, CAS
  摘要：In the age of information explosion, the exponential growth of digital data far exceeds the capacity of current mainstream storage media. DNA is emerging as a promising alternative due to its higher storage density, longer retention time, and lower power consumption. To date, commercially mature DNA synthesis and sequencing technologies allow for writing and reading of information on DNA with customization and convenience at the research level. However, under the disconnected and nonspecialize...
• Rtt105 stimulates Rad51-ssDNA assembly and orchestrates Rad51 and RPA actions to promote homologous recombination repair AI翻译
  作者：Wang, Xuejie; Zhao, Xiaocong; Yu, Zhengshi; Fan, Tianai; Guo, Yunjing; Liang, Jianqiang; Wang, Yanyan; Zhan, Jingfei; Chen, Guifang; Zhou, Chun; Zhang, Xinghua; Li, Xiangpan; Chen, Xuefeng
  作者单位：Wuhan University; Zhejiang University
  摘要：Homologous recombination (HR) is essential for the maintenance of genome stability. During HR, Replication Protein A (RPA) rapidly coats the 3 '- tailed single- strand DNA (ssDNA) generated by end resection. Then, the ssDNA-bound RPA must be timely replaced by Rad51 recombinase to form Rad51 nucleoprotein filaments that drive homology search and HR repair. How cells regulate Rad51 assembly dynamics and coordinate RPA and Rad51 actions to ensure proper HR remains poorly understood. Here, we ide...
• Capturing RAS oligomerization on a membrane AI翻译
  作者：Yun, Sangho D.; Scott, Elena; Chang, Ding - Yuan; Bahramimoghaddam, Hanieh; Lynn, Michael; Lantz, Carter; Russell, David H.; Laganowsky, Arthur
  作者单位：Texas A&M University System; Texas A&M University College Station
  摘要：RAS GTPases associate with the biological membrane where they function as molecular switches to regulate cell growth. Recent studies indicate that RAS proteins oligomerize on membranes, and disrupting these assemblies represents an alternative therapeutic strategy. However, conflicting reports on RAS assemblies, ranging in size from dimers to nanoclusters, have brought to the fore key questions regarding the stoichiometry and parameters that influence oligomerization. Here, we probe three isof...
• Geological evidence reveals a staircase pattern in Earth's rotational deceleration evolution AI翻译
  作者：Huang, He; Ma, Chao; Laskar, Jacques; Sinnesael, Matthias; Farhat, Mohammad; Hoang, Nam H.; Gao, Yuan; Zeeden, Christian; Zhong, Hanting; Hou, Mingcai; Wang, Chengshan
  作者单位：Chengdu University of Technology; Chengdu University of Technology; Ministry of Natural Resources of the People's Republic of China; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Observatoire de Paris; Sorbonne Universite; Trinity College Dublin; China University of Geosciences; Leibniz Institut fur Angewandte Geophysik (LIAG)
  摘要：The Earth's rotation has been decelerating throughout its history due to tidal dissipation, but the variation of the rate of this deceleration through time has not been established. We present a detailed analysis of eight geological datasets to constrain the Earth's rotational history from 650 to 240 Mya. The results allow us to test physical tidal models and point to a staircase pattern in the Earth's deceleration from 650 to 280 Mya. During this time interval, the Earth-Moon distance increas...
• UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma AI翻译
  作者：Su, Wenjuan; Rossi, Juan Kochen; Nuevo-Tapioles, Cristina; Chen, Ting; Kawaler, Emily; Branco, Cristina; Wong, Kwok-kin; Simeone, Diane M.; Gardner, Lawrence B.; Philips, Mark R.
  作者单位：University of California System; University of California San Diego
  摘要：Upstream frameshift 1 (UPF1) is an RNA helicase involved in a number of mRNA regulatory processes including nonsense- mediated decay. Mutations in the UPF1 locus that reduce its expression have been associated with adenosquamous carcinoma of the pancreas, a particularly aggressive form of the disease. To determine the effect of Upf1 suppression in a murine model of pancreatic adenocarcinoma, we silenced with shRNA Upf1 in cells derived from an autochthonous tumor in an LSL- Kras G12D/+ ; Trp53...
• Role of RNA structural plasticity in modulating HIV-1 genome packaging and translation AI翻译
  作者：Yasin, Saif; Lesko, Sydney L.; Kharytonchyk, Siarhei; Brown, Joshua D.; Chaudry, Issac; Geleta, Samuel A.; Tadzong, Ndeh F.; Zheng, Mei Y.; Patel, Heer B.; Kengni, Gabriel; Neubert, Emma; Quiambao, Jeanelle Mae C.; Becker, Ghazal; Ghinger, Frances Grace; Thapa, Sreeyasha; Williams, A'Lyssa; Radov, Michelle H.; Boehlert, Kellie X.; Hollmann, Nele M.; Singh, Karndeep; Bruce, James W.; Marchant, Jan; Sherer, Nathan M.; Telesnitsky, Alice; Summers, Michael F.
  作者单位：University System of Maryland; University of Maryland Baltimore County; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Michigan System; University of Michigan; University System of Maryland; University of Maryland Baltimore County; Howard Hughes Medical Institute; University System of Maryland; University of Maryland Baltimore County
  摘要：HIV-1 transcript function is controlled in part by twinned transcriptional start site usage, where 5 ' capped RNAs beginning with a single guanosine (1G) are preferentially packaged into progeny virions as genomic RNA (gRNA) whereas those beginning with three sequential guanosines (3G) are retained in cells as mRNAs. In 3G transcripts, one of the additional guanosines base pairs with a cytosine located within a conserved 5 ' polyA element, resulting in formation of an extended 5 ' polyA struct...
• Lithium isotopic evidence for enhanced reverse weathering during the Early Triassic warm period AI翻译
  作者：Rauzi, Sofia; Foster, William J.; Takahashi, Satoshi; Hori, Rie S.; Beaty, Brian J.; Tarhan, Lidya G.; Isson, Terry
  作者单位：University of Waikato; University of Hamburg; Nagoya University; Ehime University; Yale University
  摘要：Elevated temperatures persisted for an anomalously protracted interval following pulsed volcanic carbon release associated with the end- Permian mass extinction, deviating from the expected timescale of climate recovery following a carbon injection event. Here, we present evidence for enhanced reverse weathering-a CO2 source-following the end- Permian mass extinction based on the lithium isotopic composition of marine shales and cherts. We find that the average lithium isotopic composition of ...