2024

最新文章

• Collaboration can preserve the integrity of gold standard carbon data from forest inventories AI翻译
  作者：Goeking, Sara A.; Woodall, Christopher W.; Bush, Renate; Heath, Linda S.
  作者单位：United States Department of Agriculture (USDA); United States Forest Service; United States Department of Agriculture (USDA); United States Forest Service
• Effects of system- sanctioned framing on climate awareness and environmental action in the United States and beyond AI翻译
  作者：Mason, Katherine A.; Vlasceanu, Madalina; Jost, John T.
  作者单位：New York University; Stanford University
  摘要：Despite growing scientific alarm about anthropogenic climate change, the world is not on track to solve the crisis. Inaction may be partially explained by skepticism about climate change and resistance to proenvironmental policies from people who are motivated to maintain the status quo (i.e., conservative- rightists). Therefore, practical interventions are needed. In the present research program, we tested an experimental manipulation derived from system justification theory in which proenvir...
• Microbial richness and air chemistry in aerosols above the PBL confirm 2,000-km long- distance transport of potential human pathogens AI翻译
  作者：Rodo, Xavier; Pozdniakova, Sofya; Borras, Silvia; Matsuki, Atsushi; Tanimoto, Hiroshi; Armengol, Maria- Pilar; Pey, Irina; Vila, Jordi; Munoz, Laura; Santamaria, Samuel; Canas, Lidia; Morgui, Josep- Anton; Fontal, Alejandro; Curcoll, Roger
  作者单位：ICREA; ISGlobal; Kanazawa University; National Institute for Environmental Studies - Japan; University of Barcelona; Hospital Clinic de Barcelona; Instituto de Salud Carlos III; University of Barcelona; Universitat Politecnica de Catalunya
  摘要：The existence of viable human pathogens in bioaerosols which can cause infection or affect human health has been the subject of little research. In this study, data provided by 10 tropospheric aircraft surveys over Japan in 2014 confirm the existence of a vast diversity of microbial species up to 3,000 m height, which can be dispersed above the planetary boundary layer over distances of up to 2,000 km, thanks to strong winds from an area covered with massive cereal croplands in Northeast (NE) ...
• Sterol-lipids enable large- scale, liquid-liquid phase separation in bilayer membranes of only two components AI翻译
  作者：Wilson, Kent J.; Nguyen, Huy Q.; Hague, Jacquelyn Gervay -; Keller, Sarah L.
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of California System; University of California Davis; Roche Holding; Roche Holding USA; Genentech
  摘要：Despite longstanding excitement and progress toward understanding liquid-liquid phase separation in natural and artificial membranes, fundamental questions have persisted about which molecules are required for this phenomenon. Except in extraordinary circumstances, the smallest number of components that has produced large- scale, liquid-liquid phase separation in bilayers has stubbornly remained at three: a sterol, a phospholipid with ordered chains, and a phospholipid with disordered chains. ...
• QnAs with Quarraisha Abdool Karim and Salim Abdool Karim: Winners of the 2024 Lasker∼Bloomberg Public Service Award AI翻译
  作者：Davis, Tinsley H.; Karim, Quarraisha Abdool; Karim, Salim Abdool
• Inherited human RelB deficiency impairs innate and adaptive immunity to infection AI翻译
  作者：Le Voyer, Tom; Renkilaraj, Majistor Raj Luxman Maglorius; Moriya, Kunihiko; Lorenzo, Malena Perez; Nguyen, Tina; Gao, Liwei; Rubin, Tamar; Cederholm, Axel; Ogishi, Masato; Franco, Carlos A. Arango-; Beziat, Vivien; Levy, Romain; Migaud, Melanie; Rapaport, Franck; Itan, Yuval; Deenick, Elissa K.; Cortese, Irene; Lisco, Andrea; Boztug, Kaan; Abel, Laurent; Boisson-Dupuis, Stephanie; Boisson, Bertrand; Frosk, Patrick; Ma, Cindy S.; Landegren, Nils; Celmeli, Fatih; Casanova, Jean- Laurent; Tangye, Stuart G.; Puel, Anne
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Garvan Institute of Medical Research; University of New South Wales Sydney; University of Manitoba; Uppsala University; Rockefeller University; Universidad de Antioquia; Icahn School of Medicine at Mount Sinai; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Saint Anna Children's Hospital; St. Anna Children's Cancer Research Institute (CCRI); Medical University of Vienna; Austrian Academy of Sciences; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences; University of Manitoba; Antalya Training & Research Hospital; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Howard Hughes Medical Institute
  摘要：We report two unrelated adults with homozygous (P1) or compound heterozygous (P2) private loss- of- function variants of V-Rel Reticuloendotheliosis Viral Oncogene Homolog B ( RELB ) . The resulting deficiency of functional RelB impairs the induction of NFKB2 mRNA and NF-kappa B2 (p100/p52) protein by lymphotoxin in the fibroblasts of the patients. These defects are rescued by transduction with wild- type RELB complementary DNA (cDNA). By contrast, the response of RelB- deficient fibroblasts t...
• Evolution fails to rescue a population in an increasingly variable environment AI翻译
  作者：Olazcuaga, Laure; Hufbauer, Ruth A.
  作者单位：Centre National de la Recherche Scientifique (CNRS); Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins
• Efficient asymmetric diffusion channel in MnCo2O4 spinel for ammonium- ion batteries AI翻译
  作者：Xiao, Kang; Xiao, Bo-Hao; Li, Jian-Xi; Cao, Shunsheng; Liu, Zhao-Qing
  作者单位：Guangzhou University; Guangzhou University; Guangzhou University; Jiangsu University
  摘要：Transition metal oxides ion diffusion channels have been developed for ammonium- ion batteries (AIBs). However, the influence of microstructural features of diffusion channels on the storage and diffusion behavior of NH4+is not fully unveiled. In this study, by using MnCo2O4 spinel as a model electrode, the asymmetric ion diffusion channels of MnCo2O4 have been regulated through bond length optimization strategy and investigate the effect of channel size on the diffusion process of NH4+. In ad...
• Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases AI翻译
  作者：Kueck, Anja F.; van den Boom, Johannes; Koska, Sandra; Ron, David; Meyer, Hemmo
  作者单位：University of Duisburg Essen; University of Cambridge
  摘要：Protein phosphatase-1 catalytic subunit (PP1) joins diverse targeting subunits to form holophosphatases that regulate many cellular processes. Newly synthesized PP1 is known to be transiently sequestered in an inhibitory complex with Suppressor- of-Dis2- number- 2 (SDS22) and Inhibitor- 3 (I3), which is disassembled by the ATPases Associated with diverse cellular Activities plus (AAA+) protein p97. Here, we show that the SDS22- PP1-I3 complex also acts as a thermodynamic sink for mature PP1 an...
• Functional dissection of mosquito humidity sensing reveals distinct Dry and Moist Cell contributions to blood feeding and oviposition AI翻译
  作者：Tang, Ruocong; Busby, Rachel; Laursen, Willem J.; Keane, Geoffrey T.; Garrity, Paul A.
  作者单位：Brandeis University; Brandeis University
  摘要：Aeries aegypti mosquitoes are major vectors of dengue, chikungunya, and other arboviral diseases. Ae. aegypti's capacity to reproduce and to spread disease depends on the female mosquitoes' ability to obtain blood meals and find water- filled containers in which to lay eggs (oviposit). While humidity sensation (hygrosensation) has been implicated in these behaviors, the specific hygrosensory pathways involved have been unclear. Here, we establish the distinct molecular requirements and anatomi...