2024

最新文章

• IL-13 and IL-17A activate β1 integrin through an NF- kB/Rho kinase/PIP5K1γ pathway to enhance force transmission in airway smooth muscle AI翻译
  作者：Ngo, Uyen; Shi, Ying; Woodruff, Prescott; Shokat, Kevan; Degrado, William; Jo, Hyunil; Sheppard, Dean; Sundaram, Aparna B.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Howard Hughes Medical Institute; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Integrin activation resulting in enhanced adhesion to the extracellular matrix plays a key role in fundamental cellular processes. Although integrin activation has been extensively studied in circulating cells such as leukocytes and platelets, much less is known about the regulation and functional impact of integrin activation in adherent cells such as smooth muscle. Here, we show that two different asthmagenic cytokines, IL- 13 and IL- 17A, activate type I and IL- 17 cytokine receptor familie...
• Naturally occurring horse model of miscarriage reveals temporal relationship between chromosomal aberration type and point of lethality AI翻译
  作者：Lawson, Jessica M.; Salem, Shebl E.; Miller, Donald; Kahler, Anne; Boer, Wilhelmina J. van den; Shilton, Charlotte A.; Sever, Tia; Mouncey, Rebecca R.; Ward, Jenna; Hampshire, Daniel J.; Foote, Alastair K.; Bryan, Jill S.; Juras, Rytis; Pynn, Oliver D.; Davis, Brian W.; Bellone, Rebecca R.; Raudsepp, Terje; de Mestre, Amanda M.
  作者单位：University of London; University of London Royal Veterinary College; Cornell University; Texas A&M University System; Texas A&M University College Station; University of California System; University of California Davis; University of California System; University of California Davis
  摘要：Chromosomal abnormalities are a common cause of human miscarriage but rarely reported in any other species. As a result, there are currently inadequate animal models available to study this condition. Horses present one potential model since mares receive intense gynecological care. This allowed us to investigate the prevalence of chromosomal copy number aberrations in 256 products of conception (POC) in a naturally occurring model of pregnancy loss (PL). Triploidy (three haploid sets of chrom...
• Lining the small intestine with mycobacteriophages protects from Mycobacterium avium subsp. paratuberculosis and eliminates fecal shedding AI翻译
  作者：McKenna, Victoria K. Harman-; Eshraghisamani, Razieh; Shafer, Natali; De Buck, Jeroen
  作者单位：University of Calgary
  摘要：Johne's disease (JD), a chronic, infectious enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP), affects wild and domestic ruminants. There is no cure or effective prevention, and current vaccines have substantial limitations, leaving this disease widespread in all substantial dairy industries causing economic, and animal welfare implications. Mycobacteriophages (MPs) have been gaining interest in recent years and are proposed as a promising solution to curtailing MAP infecti...
• Structure-driven development of a biomimetic rare earth artificial metalloprotein AI翻译
  作者：Thompson, Peter J.; Boggs, David G.; Wilson, Charles A.; Bruchs, Austin T.; Velidandla, Uditha; Bridwell-Rabb, Jennifer; Olshansky, Lisa
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Michigan System; University of Michigan; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：The 2011 discovery of the first rare earth-dependent enzyme in methylotrophic Methylobacterium extorquens AM1 prompted intensive research toward understanding the unique chemistry at play in these systems. This enzyme, an alcohol dehydrogenase (ADH), features a La3+ ion closely associated with redox- active coenzyme pyrroloquinoline quinone (PQQ) and is structurally homologous to the Ca2+- dependent ADH from the same organstructurally characterized to 1.46- & Aring; resolution by X- ray diffra...
• Nutrient and moisture limitations reveal keystone metabolites linking rhizosphere metabolomes and microbiomes AI翻译
  作者：Baker, Nameer R.; Zhalnina, Kateryna; Yuan, Mengting; Herman, Don; Ceja-Navarro, Javier A.; Sasse, Joelle; Jordan, Jacob S.; Bowen, Benjamin P.; Wu, Liyou; Fossum, Christina; Chew, Aaron; Fu, Ying; Saha, Malay; Zhou, Jizhong; Pett-Ridge, Jennifer; Northen, Trent R.; Firestone, Mary K.
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Northern Arizona University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Zurich; University of California System; University of California Berkeley; University of Oklahoma System; University of Oklahoma - Norman; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Noble Research Institute; University of California System; University of California Merced
  摘要：Plants release a wealth of metabolites into the rhizosphere that can shape the composition and activity of microbial communities in response to environmental stress. The connection between rhizodeposition and rhizosphere microbiome succession has been suggested, particularly under environmental stress conditions, yet definitive evidence is scarce. In this study, we investigated the relationship between rhizosphere chemistry, microbiome dynamics, and abiotic stress in the bioenergy crop switchg...
• Climate change and public health in California: A structured review of exposures, vulnerable populations, and adaptation measures AI翻译
  作者：Jerrett, Michael; Connolly, Rachel; Garcia-Gonzales, Diane A.; Bekker, Claire; Nguyen, Jenny T.; Su, Jason; Li, Yang; Marlier, Miriam E.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Berkeley; Baylor University
  摘要：California faces several serious direct and indirect climate exposures that can adversely affect public health, some of which are already occurring. The public health burden now and in the future will depend on atmospheric greenhouse gas concentrations, underlying population vulnerabilities, and adaptation efforts. Here, we present a structured review of recent literature to examine the leading climate risks to public health in California, including extreme heat, extreme precipitation, wildfir...
• Incomplete transcriptional dosage compensation of chicken and platypus sex chromosomes is balanced by post- transcriptional compensation AI翻译
  作者：Lister, Nicholas C.; Milton, Ashley M.; Patel, Hardip R.; Waters, Shafagh A.; Hanrahan, Benjamin J.; McIntyre, Kim L.; Livernois, Alexandra M.; Horspool, William B.; Wee, Lee Kian; Ringel, Alessa R.; Mundlos, Stefan; Robson, Michael I.; Shearwin-Whyatt, Linda; Grutzner, Frank; Graves, Jennifer A. Marshall; Ruiz-Herrera, Aurora; Waters, Paul D.
  作者单位：University of New South Wales Sydney; Australian National University; John Curtin School of Medical Research; Australian National University; University of New South Wales Sydney; Max Planck Society; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; University of Edinburgh; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Adelaide; La Trobe University; University of Canberra; Autonomous University of Barcelona; Autonomous University of Barcelona
  摘要：Heteromorphic sex chromosomes (XY or ZW) present problems of gene dosage imbalance between sexes and with autosomes. A need for dosage compensation has long been thought to be critical in vertebrates. However, this was questioned by findings of unequal mRNA abundance measurements in monotreme mammals and birds. Here, we demonstrate unbalanced mRNA levels of X genes in platypus males and females and a correlation with differential loading of histone modifications. We also observed unbalanced tr...
• The health risk of social disadvantage is transplantable into a new host AI翻译
  作者：Turcotte, Lucie M.; Wang, Tao; Beyer, Kirsten M.; Cole, Steven W.; Spellman, Stephen R.; Johnson, Mariam Allbee -; Williams, Eric; Zhou, Yuhong; Verneris, Michael R.; Rizzo, J. Douglas; Knight, Jennifer M.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; Center for International Blood & Marrow Transplant Research; Medical College of Wisconsin; Medical College of Wisconsin; Medical College of Wisconsin; University of California System; University of California Los Angeles; National Marrow Donor Program; Center for International Blood & Marrow Transplant Research; Children's Hospital Colorado; University of Colorado System; University of Colorado Denver; University of Colorado Anschutz Medical Campus; Medical College of Wisconsin; Medical College of Wisconsin
  摘要：Low socioeconomic status (SES) is a risk factor for mortality and immune dysfunction across a wide range of diseases, including cancer. However, cancer is distinct in the use of allogeneic hematopoietic cell transplantation (HCT) as a treatment for hematologic malignancies to transfer healthy hematopoietic cells from one person to another. This raises the question of whether social disadvantage of an HCT cell donor, as assessed by low SES, might impact the subsequent health outcomes of the HCT...
• Recombinant OC43 SARS-CoV-2 spike replacement virus: An improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays AI翻译
  作者：Hu, Zhe; Lopez-Munoz, Alberto Domingo; Kosik, Ivan; Li, Tiansheng; Callahan, Victoria; Brooks, Kelsie; Yee, Debra S.; Holly, Jaroslav; Santos, Jefferson J. S.; Brant, Ayslan Castro; Johnson, Reed F.; Takeda, Kazuyo; Zheng, Zhi - Ming; Brenchley, Jason M.; Yewdell, Jonathan W.; Fox, Julie M.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); US Food & Drug Administration (FDA); Center for Biologics Evaluation & Research (CBER)
  摘要：We generated a replication-- competent OC43 human seasonal coronavirus (CoV) expressing the severe acute respiratory syndrome coronavirus 2 (SARS-- CoV-2)- 2) spike in place of the native spike (rOC43-CoV2- CoV2 S). This virus is highly attenuated relative to OC43 and SARS-CoV-2- CoV- 2 in cultured cells and animals and is classified as a biosafety level 2 (BSL-2)- 2) agent by the NIH biosafety committee. Neutralization of rOC43-CoV2- CoV2 S and SARS-CoV-2- CoV- 2 by S-- specific monoclonal an...
• Antigen- specific age- related memory CD8 T cells induce and track Alzheimer's- like neurodegeneration AI翻译
  作者：Panwar, Akanksha; Rentsendorj, Altan; Jhun, Michelle; Cohen, Robert M.; Cordner, Ryan; Gull, Nicole; Pechnick, Robert N.; Duvall, Gretchen; Mardiros, Armen; Golchian, David; Schubloom, Hannah; Jin, Lee - Way; Van Dam, Debby; Vermeiren, Yannick; De Reu, Hans; Deyn, Peter Paul De; Raskatov, Jevgenij A.; Black, Keith L.; Irvin, Dwain K.; Williams, Brian A.; Wheeler, Christopher J.
  作者单位：Cedars Sinai Medical Center; Emory University; Emory University; Cedars Sinai Medical Center; Western University of Health Sciences; University of California System; University of California Davis; University of Antwerp; University of Groningen; University of Groningen; University of Groningen; University of Antwerp; Wageningen University & Research; University of Antwerp; University of California System; University of California Santa Cruz; California Institute of Technology; Brigham Young University
  摘要：Cerebral (Af3) f3 ) plaque and (pTau) tangle deposition are hallmarks of Alzheimer's disease (AD), yet are insufficient to confer complete AD- like neurodegeneration experimentally. Factors acting upstream of Af3/pTau f3 /pTau in AD remain unknown, but their identification could enable earlier diagnosis and more effective treatments. T cell abnormalities are emerging AD hallmarks, and CD8 T cells were recently found to mediate neurodegeneration downstream of tangle deposition in hereditary neu...