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作者：Lobel, Graham P.; Han, Nanumi; Arocho, William A. Molina; Silber, Michal; Shoush, Jason; Noji, Michael C.; To, Tsun Ki Jerrick; Zhai, Li; Lesner, Nicholas P.; Simon, M. Celeste; Haldar, Malay
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Proliferating tumor cells take up glutamine for anabolic processes, engendering glutamine deficiency in the tumor microenvironment. How this might impact immune cells is not well understood. Using multiple mouse models of soft tissue sarcomas, glutamine antagonists, as well as genetic and pharmacological inhibition of glutamine utilization, we found that the number and frequency of conventional dendritic cells (cDCs) is dependent on microenvironmental glutamine levels. cDCs comprise two distin...
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作者：Lu, I-Te; Shin, Dongbin; Svendsen, Mark Kamper; Hubener, Hannes; De Giovannini, Umberto; Latini, Simone; Ruggenthaler, Michael; Rubio, Angel
作者单位：Max Planck Society; Gwangju Institute of Science & Technology (GIST); University of Copenhagen; Niels Bohr Institute; University of Palermo; Technical University of Denmark; Simons Foundation; Flatiron Institute
摘要：Strong laser pulses can control superconductivity, inducing nonequilibrium transient pairing by leveraging strong-light matter interaction. Here, we demonstrate theoretically that equilibrium ground-state phonon-mediated superconductive pairing can be affected through the vacuum fluctuating electromagnetic field in a cavity. Using the recently developed ab initio quantum electrodynamical density-functional theory approximation, we specifically investigate the phonon-mediated superconductive be...
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作者：Songa, Min; Shin, Eun Ju; Seod, Hyojung; Soltanie, Alireza; Steinmetz, Nicholas A.; Lee, Daeyeol; Jung, Min Whan; Paikk, Se-Bum
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Institute for Basic Science - Korea (IBS); Yale University; University of Washington; University of Washington Seattle; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Korea Advanced Institute of Science & Technology (KAIST)
摘要：Many anatomical and physiological features of cortical circuits, ranging from the biophysical properties of synapses to the connectivity patterns among different neuron types, exhibit consistent variation along the hierarchical axis from sensory to association areas. Notably, the temporal correlation of neural activity at rest, known as the intrinsic timescale, increases systematically along this hierarchy in both primates and rodents, analogous to the increasing scale and complexity of spatia...
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作者：Holliday, Derek E.; Lelkes, Yphtach; Westwood, Sean J.
作者单位：Stanford University; University of Pennsylvania; Dartmouth College
摘要：The attempted assassination of Donald Trump led to widespread concern that the event would escalate political violence between U.S. partisans. While some politicians pleaded for Americans to unite against political violence and turn down the temperature on partisan hostility, others continued to engage in inflammatory rhetoric and blame. Using a national survey in the field at the time of the assassination attempt, we take the temperature of America's partisans before and after the event. We e...
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作者：Kim, Hyunbae; Chen, Qi; Ju, Donghong; Purandare, Neeraja; Chen, Xuequn; Samavati, Lobelia; Li, Li; Zhang, Ren; Grossman, Lawrence I.; Zhang, Kezhong
作者单位：Wayne State University; Wayne State University; Wayne State University
摘要：The Mitochondrial Unfolded Protein Response (UPRmt), a mitochondria- originated stress response to altered mitochondrial proteostasis, plays important roles in various pathophysiological processes. In this study, we revealed that the endoplasmic reticulum (ER)- tethered stress sensor CREBH regulates UPRmt to maintain mitochondrial homeostasis and function in the liver. CREBH is enriched in and required for hepatic Mitochondria- Associated Membrane (MAM) expansion induced by energy demands. Und...
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作者：Palin, Richard; Wade, Jon; Dyck, Brendan
作者单位：University of Oxford; University of British Columbia
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作者：Lala, Kevin N.; Feldman, Marcus W.
作者单位：University of St Andrews; Stanford University
摘要：Quantitative studies of cultural evolution and gene- culture coevolution (henceforth CE and GCC) emerged in the 1970s, in the aftermath of the race and intelligence quotient (IQ) and human sociobiology debates, as a counter to extreme hereditarian positions. These studies incorporated cultural transmission and its interaction with genetics in contributing to patterns of human variation. Neither CE nor GCC results were consistent with racist claims of ubiquitous genetic differences between soci...
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作者：Fang, Bohao; Edwards, Scott V.
作者单位：Harvard University; Harvard University
摘要：Genomic structural variants (SVs) play a crucial role in adaptive evolution, yet their average fitness effects and characterization with pangenome tools are understudied in wild animal populations. We constructed a pangenome for House Finches (Haemorhous mexicanus), a model for studies of host- pathogen coevolution, using long- read sequence data on 16 individuals (32 de novo- assembled haplotypes) and one outgroup. We identified 887,118 SVs larger than 50 base pairs, mostly (60%) involving re...
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作者：Foged, Mads M.; Recazens, Emeline; Chollet, Sylvain; Lisci, Miriam; Allen, George E.; Zinshteyn, Boris; Boutguetait, Doha; Muench, Christian; Mootha, Vamsi K.; Jourdain, Alexis A.
作者单位：University of Lausanne; University of Geneva; Johns Hopkins University; Howard Hughes Medical Institute; Johns Hopkins University; Goethe University Frankfurt; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School
摘要：Mitochondrial biogenesis relies on both the nuclear and mitochondrial genomes, and imbalance in their expression can lead to inborn errors of metabolism, inflammation, and aging. Here, we investigate N6AMT1, a nucleo- cytosolic methyltransferase that exhibits genetic codependency with mitochondria. We determine transcriptional and translational profiles of N6AMT1 and report that it is required for the cytosolic translation of TRMT10C (MRPP1) and PRORP (MRPP3), two subunits of the mitochondrial...
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作者：Hardikar, Aditya, V; Hauser, Adam W.; Hopkins, Terrence M.; Sacanna, Stefano; Chaikin, Paul M.
作者单位：New York University; New York University
摘要：Microscale objects responding to chemical gradients by migrating toward or away from a preferred species is a simple yet constitutive mechanism by which transport occurs in biological organisms. Synthetic chemotaxis provides key physical descriptions of simplified systems that can be used in biological models, or in the creation of advanced responsive material systems. In this article, we provide a quantitative framework for understanding synthetic chemotaxis of microparticles which involves a...
