2024

最新文章

• Renormalization group analysis of the Anderson model on random regular graphs AI翻译
  作者：Vanoni, Carlo; Altshuler, Boris; Kravtsovd, Vladimir E.; Scardicchiob, Antonello
  作者单位：International School for Advanced Studies (SISSA); Istituto Nazionale di Fisica Nucleare (INFN); Columbia University; Abdus Salam International Centre for Theoretical Physics (ICTP)
  摘要：We present a renormalization group (RG) analysis of the problem of Anderson localization on a random regular graph (RRG) which generalizes the RG of Abrahams, Anderson, Licciardello, and Ramakrishnan to infinite-dimensional graphs. The RG equations necessarily involve two parameters (one being the changing connectivity of subtrees), but we show that the one-parameter scaling hypothesis is recovered for sufficiently large system sizes for both eigenstates and spectrum observables. We also expla...
• Nucleosomes play a dual role in regulating transcription dynamics AI翻译
  作者：Brahmachari, Sumitabha; Tripathi, Shubham; Onuchic, Jose N.; Levine, Herbert
  作者单位：Rice University; Rice University; Rice University; Rice University; Rice University; Northeastern University; Northeastern University; Yale University; Yale University
  摘要：Transcription has a mechanical component, as the translocation of the transcription machinery or RNA polymerase (RNAP) on DNA or chromatin is dynamically coupled to the chromatin torsion. This posits chromatin mechanics as a possible regulator of eukaryotic transcription, however, the modes and mechanisms of this regulation are elusive. Here, we first take a statistical mechanics approach to model the torsional response of topology-constrained chromatin. Our model recapitulates the experimenta...
• The CRL3KCTD10 ubiquitin ligase-USP18 axis coordinately regulates cystine uptake and ferroptosis by modulating SLC7A11 AI翻译
  作者：Zhou, Qiyin; Yu, Hongfei; Chen, Yongxia; Ren, Jiayi; Lu, Yan; Sun, Yi
  作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University
  摘要：SLC7A11 is a cystine transporter and ferroptosis inhibitor. How the stability of SLC7A11 is coordinately regulated in response to environmental cystine by which E3 ligase and deubiquitylase (DUB) remains elusive. Here, we report that neddylation inhibitor MLN4924 increases cystine uptake by causing SLC7A11 accumulation, via inactivating Cullin-RING ligase-3 (CRL-3). We identified KCTD10 as the substrate- recognizing subunit of CRL-3 for SLC7A11 ubiquitylation, and USP18 as SLC7A11 deubiquityla...
• Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel AI翻译
  作者：Karuppan, Sebastian; Schrag, Lynn Goss; Pastrano, Caroline M.; Jara-Oseguera, Andres; Zubcevic, Lejla
  作者单位：University of Kansas; University of Kansas Medical Center; University of Texas System; University of Texas Austin; Arizona State University; Arizona State University-Tempe
  摘要：The transient receptor potential melastatin (TRPM) tetrameric cation channels are involved in a wide range of biological functions, from temperature sensing and taste transduction to regulation of cardiac function, inflammatory pain, and insulin secretion. The structurally conserved TRPM cytoplasmic domains make up >70 % of the total protein. To investigate the mechanism by which the TRPM cytoplasmic domains contribute to gating, we employed electrophysiology and cryo-EM to study TRPM5-a chann...
• Mycobacterium tuberculosis Rv2224c modulates innate immune responses (vol 105, pg 264, 2008) AI翻译
  作者：Rengarajan, Jyothi; Murphy, Elissa; Park, Arnold; Krone, Cassandra L.; Hett, Erik C.; Bloom, Barry R.; Glimcher, Laurie H.; Rubin, Eric J.
• Structural determinants of ivabradine block of the open pore of HCN4 AI翻译
  作者：Saponaro, Andrea; Krumbach, Jan H.; Chaves-Sanjuan, Antonio; Sharifzadeh, Atiyeh Sadat; Porro, Alessandro; Castelli, Roberta; Hamacher, Kay; Bolognesi, Martino; DiFrancesco, Dario; Clarke, Oliver B.; Thiel, Gerhard; Moroni, Anna
  作者单位：University of Milan; Technical University of Darmstadt; Technical University of Darmstadt; Technical University of Darmstadt; University of Milan; Consiglio Nazionale delle Ricerche (CNR); Columbia University; Columbia University; NewYork-Presbyterian Hospital; Columbia University
  摘要：HCN1- 4 channels are the molecular determinants of the If/Ih current that crucially regulates cardiac and neuronal cell excitability. HCN dysfunctions lead to sinoatrial block (HCN4), epilepsy (HCN1), and chronic pain (HCN2), widespread medical conditions awaiting subtype- specific treatments. Here, we address the problem by solving the cryo- EM structure of HCN4 in complex with ivabradine, to date the only HCN- specific drug on the market. Our data show ivabradine bound inside the open pore a...
• SARS-CoV-2 Nsp1 traps RNA in the nucleus to escape immune detection AI翻译
  作者：Guillen, Jaresley V.; Glaunsinger, Britt A.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute
• Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA- 665752 (vol 103, pg 2316, 2006) AI翻译
  作者：Smolen, Gromoslaw A.; Sordella, Raffaella; Muir, Beth; Mohapatra, Gayatry; Barmettler, Anne; Archibald, Heidi; Kim, Woo J.; Okimoto, Ross A.; Bell, Daphne W.; Sgroi, Dennis C.; Christensen, James G.; Settleman, Jeffrey; Haber, Daniel A.
• Engineering an inducible leukemia- associated fusion protein enables large- scale ex vivo production of functional human phagocytes AI翻译
  作者：Windisch, Roland; Soliman, Sarah; Hoffmann, Adrian; Chen-Wichmann, Linping; Danese, Anna; Vosberg, Sebastian; Bravo, Jimena; Lutz, Sebastian; Kellner, Christian; Fischer, Alexander; Gebhard, Claudia; Monte, Enric Redondo; Hartmann, Luise; Schneider, Stephanie; Beier, Fabian; Strobl, Carolin Dorothea; Weigert, Oliver; Peipp, Matthias; Schuendeln, Michael; Stricker, Stefan H.; Rehli, Michael; Bernhagen, Juergen; Humpe, Andreas; Klump, Hannes; Brendel, Christian; Krause, Daniela S.; Greif, Philipp A.; Wichmann, Christian
  作者单位：University of Munich; University of Munich; University of Munich; University of Munich; University of Munich; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Medical University of Graz; Octapharma; University of Regensburg; University of Munich; University of Munich; RWTH Aachen University; RWTH Aachen University Hospital; University of Kiel; University of Duisburg Essen; University of Duisburg Essen; University of Munich; University of Duisburg Essen; RWTH Aachen University; RWTH Aachen University Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Boston Children's Hospital; Goethe University Frankfurt; Goethe University Frankfurt Hospital
  摘要：Ex vivo expansion of human CD34+ hematopoietic stem and progenitor cells remains a challenge due to rapid differentiation after detachment from the bone marrow niche. In this study, we assessed the capacity of an inducible fusion protein to enable sustained ex vivo proliferation of hematopoietic precursors and their capacity to differentiate into functional phagocytes. We fused the coding sequences of an FK506- Binding Protein 12 (FKBP12)- derived destabilization domain (DD) to the myeloid/lym...
• Different ER-plasma membrane tethers play opposing roles in autophagy of the cortical ER AI翻译
  作者：Liu, Dongmei; Yuan, Hua; Chen, Shuliang; Ferro-Novick, Susan; Novick, Peter
  作者单位：University of California System; University of California San Diego
  摘要：The endoplasmic reticulum (ER) undergoes degradation by selective macroautophagy (ER - phagy) in response to starvation or the accumulation of misfolded proteins within its lumen. In yeast, actin assembly at sites of contact between the cortical ER (cER) and endocytic pits acts to displace elements of the ER from their association with the plasma membrane (PM) so they can interact with the autophagosome assembly machinery near the vacuole. A collection of proteins tether the cER to the PM. Of ...