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作者：Geng, Sha; Liu, Song- Bai; He, Wei; Pan, Xiangbin; Sun, Yi; Xue, Ting; Han, Shiyuan; Lou, Jing; Chang, Ying; Zheng, Jiqing; Shi, Xinghong; Li, Yangxin; Song, Yao- Hua
作者单位：Soochow University - China; Soochow University - China; Soochow University - China; Suzhou Vocational Health College; Chinese Academy of Medical Sciences - Peking Union Medical College; Fu Wai Hospital - CAMS; Peking Union Medical College
摘要：Myogenic regeneration relies on the proliferation and differentiation of satellite cells. TECRL (trans - 2,3 - enoyl - CoA reductase like) is an endoplasmic reticulum protein only expressed in cardiac and skeletal muscle. However, its role in myogenesis remains unknown. We show that TECRL expression is increased in response to injury. Satellite cell - specific deletion of TECRL enhances muscle repair by increasing the expression of EGR2 through the activation of the ERK1/2 signaling pathway, w...
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作者：van Zwieten, Ralph; Bierman, Thijs V.; Klinkhamer, Peter G. L.; Bezemer, T. Martijn; Vrieling, Klaas; Kodger, Thomas E.
作者单位：Wageningen University & Research; Leiden University - Excl LUMC; Leiden University
摘要：With a continuous increase in world population and food production, chemical pesticide use is growing accordingly, yet unsustainably. As chemical pesticides are harmful to the environment and developmental resistance in pests is increasing, a sustainable and effective pesticide alternative is needed. Inspired by nature, we mimic one defense strategy of plants, glandular trichomes, to shift away from using chemical pesticides by moving toward a physical immobilization strategy via adhesive part...
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作者：Zhu, Xiaohong; Luo, Mengqi; An, Ke; Shi, Danfeng; Hou, Tingjun; Warshel, Arieh; Bai, Chen
作者单位：The Chinese University of Hong Kong, Shenzhen; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Shenzhen University; Zhejiang University; University of Southern California
摘要：Homomeric dimerization of metabotropic glutamate receptors (mGlus) is essential for the modulation of their functions and represents a promising avenue for the development of novel therapeutic approaches to address central nervous system diseases. Yet, the scarcity of detailed molecular and energetic data on mGlu2 impedes our in - depth comprehension of their activation process. Here, we employ computational simulation methods to elucidate the activation process and key events associated with ...
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作者：Nicholson, Michael D.; Anderson, Craig J.; Odom, Duncan T.; Aitken, Sarah J.; Taylor, Martin S.
作者单位：University of Edinburgh; University of Edinburgh; Helmholtz Association; German Cancer Research Center (DKFZ); University of Cambridge; Cancer Research UK; CRUK Cambridge Institute; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of Cambridge
摘要：DNA base damage is a major source of oncogenic mutations and disruption to gene expression. The stalling of RNA polymerase II (RNAP) at sites of DNA damage and the subsequent triggering of repair processes have major roles in shaping the genome - wide distribution of mutations, clearing barriers to transcription, and minimizing the production of miscoded gene products. Despite its importance for genetic integrity, key mechanistic features of this transcription - coupled repair (TCR) process ar...
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作者：Calvin, Jason J.; Brewer, Amanda S.; Crook, Michelle F.; Kaufman, Tierni M.; Alivisatos, Paul
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：Surface energy is a fundamental property of materials and is particularly important in describing nanomaterials where atoms or molecules at the surface constitute a large fraction of the material. Traditionally, surface energy is considered to be a positive quantity, where atoms or molecules at the surface are less thermodynamically stable than their counterparts in the interior of the material because they have fewer bonds or interactions at the surface. Using calorimetric methods, we show th...
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作者：Lv, Guangxin; Tu, Yaodong; Zhang, James H.
作者单位：Massachusetts Institute of Technology (MIT)
摘要：Although water is almost transparent to visible light, we demonstrate that the air-water interface interacts strongly with visible light via what we hypothesize as the photomolecular effect. In this effect, transverse - magnetic polarized photons cleave off water clusters from the air-water interface. We use 14 different experiments to demonstrate the existence of this effect and its dependence on the wavelength, incident angle, and polarization of visible light. We further demonstrate that vi...
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作者：De, Kavita; Belardinelli, Juan M.; Pandurangan, Arun Prasad; Ehianeta, Teddy; Lian, Elena; Palcekova, Zuzana; Lam, Ha; Gonzalez-juarrero, Mercedes; Bryant, Josephine M.; Blundell, Tom L.; Parkhill, Julian; Floto, R. Andres; Lowary, Todd L.; Wheat, William H.; Jackson, Mary
作者单位：Colorado State University System; Colorado State University Fort Collins; Academia Sinica - Taiwan; University of Cambridge; University of Cambridge; MRC Laboratory Molecular Biology; University of Cambridge; Papworth Hospital; National Taiwan University
摘要：Mycobacterium abscessus is increasingly recognized as the causative agent of chronic pulmonary infections in humans. One of the genes found to be under strong evolutionary pressure during adaptation of M. abscessus to the human lung is embC which encodes an arabinosyltransferase required for the biosynthesis of the cell envelope lipoglycan, lipoarabinomannan (LAM). To assess the impact of patient - derived embC mutations on the physiology and virulence of M. abscessus , mutations were introduc...
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作者：Fukami, Yusuke; Ariizumi, Ryoko; Ijichi, Yuta; Ohno, Takeshi; Kashiwabara, Teruhiko; Shibuya, Takazo; Suzuki, Katsuhiko; Hirata, Takafumi
作者单位：Gakushuin University; University of Tokyo; Japan Agency for Marine-Earth Science & Technology (JAMSTEC); Japan Agency for Marine-Earth Science & Technology (JAMSTEC)
摘要：Experimental results are presented showing the variation in the relationship between odd isotopes of tin (Sn) in mass - independent fractionation caused by the magnetic isotope effect (MIE), which has previously only been observed for mercury. These results are consistent with the trend predicted from the difference between the magnitudes of nuclear magnetic moments of odd isotopes with a nuclear spin. However, the correlation between odd isotopes in fractionation induced by the MIE for the re...
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作者：Marzuki, Sangkot; Buchori, Damayanti; Alberts, Bruce
作者单位：Bogor Agricultural University; University of California System; University of California San Francisco
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作者：Charbonneau, Joey A.; Santistevan, Anthony C.; Raven, Erika P.; Bennett, Jeffrey L.; Russ, Brian E.; Bliss-Moreau, Eliza
作者单位：University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis; New York University; University of California System; University of California Davis; California State University System; California State University Sacramento; Nathan Kline Institute for Psychiatric Research; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; New York University
摘要：Affective touch-a slow, gentle, and pleasant form of touch-activates a different neural network than which is activated during discriminative touch in humans. Affective touch perception is enabled by specialized low-threshold mechanoreceptors in the skin with unmyelinated fibers called C tactile (CT) afferents. These CT afferents are conserved across mammalian species, including macaque monkeys. However, it is unknown whether the neural representation of affective touch is the same across spec...
