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作者：Page, Jacob; Norgaard, Peter; Brenner, Michael P.; Kerswell, Rich R.
作者单位：University of Edinburgh; Alphabet Inc.; Google Incorporated; Harvard University; University of Cambridge
摘要：A dynamical systems approach to turbulence envisions the flow as a trajectory through a high-dimensional state space [Hopf, Commun. Appl. Maths 1, 303 (1948)]. The chaotic dynamics are shaped by the unstable simple invariant solutions populating the inertial manifold. The hope has been to turn this picture into a predictive framework where the statistics of the flow follow from a weighted sum of the statistics of each simple invariant solution. Two outstanding obstacles have prevented this goa...
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作者：Bokros, Michael; Balukoff, Nathan C.; Grunfeld, Alex; Sebastiao, Mathew; Beurel, Eleonore; Bourgault, Steve; Lee, Stephen
作者单位：University of Miami; University of Miami; University of Quebec; University of Quebec Montreal; University of Miami
摘要：The RNA tailing machinery adds nucleotides to the 3 '- end of RNA molecules that are implicated in various biochemical functions, including protein synthesis and RNA stability. Here, we report a role for the RNA tailing machinery as enzymatic modifiers intracellular amyloidogenesis. A targeted RNA interference screen identified Terminal Nucleotidyl - transferase 4b (TENT4b/Papd5) as an essential participant in the amyloidogenic phase transition of nucleoli into solid - like Amyloid bodies. Ful...
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作者：Jiang, Yu; Ye, Dong; Li, Aokang; Zhang, Bo; Han, Wenhu; Niu, Xuechen; Zeng, Mingtao; Guo, Lianbo; Zhang, Guanjun; Yin, Zhouping; Huang, Yongan
作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; Xi'an Jiaotong University; Huazhong University of Science & Technology
摘要：Seamless integration of microstructures and circuits on three- dimensional (3D) complex surfaces is of significance and is catalyzing the emergence of many innovative 3D curvy electronic devices. However, patterning fine features on arbitrary 3D targets remains challenging. Here, we propose a facile charge- driven electrohydrodynamic 3D microprinting technique that allows micron- and even submicron- scale patterning of functional inks on a couple of 3D- shaped dielectrics via an atmospheric- p...
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作者：Martinez-Corral, Rosa; Nam, Kee-Myoung; Depace, Angela H.; Gunawardena, Jeremy
作者单位：Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Yale University
摘要：The Hill functions, H-h(x) = x(h)=(1 + x(h)), have been widely used in biology for over a century but, with the exception of H-1, they have had no justification other than as a convenient fit to empirical data. Here, we show that they are the universal limit for the sharpness of any input-output response arising from a Markov process model at thermodynamic equilibrium. Models may represent arbitrary molecular complexity, with multiple ligands, internal states, conformations, coregulators, etc,...
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作者：Maso, Lorenzo; Rajak, Epsa; Bang, Injin; Koide, Akiko; Hattori, Takamitsu; Neel, Benjamin G.; Koide, Shohei
作者单位：New York University; New York University; New York University
摘要：The HapImmune TM platform exploits covalent inhibitors as haptens for creating major histocompatibility complex (MHC) - presented tumor - specific neoantigens by design, combining targeted therapies with immunotherapy for the treatment of drug - resistant cancers. A HapImmune antibody, R023, recognizes multiple sotorasib - conjugated KRAS(G12C) peptides presented by different human leukocyte antigens (HLAs). This high specificity to sotorasib, coupled with broad HLA - binding capability, enabl...
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作者：Mazar, Nina; Elbaek, Christian T.; Mitkidis, Panagiotis
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作者：Potter, Sarah C.; Gibbs, Bettine E.; Hammel, Forrest A.; Joiner, Cassandra M.; Paulo, Joao A.; Janetzko, John; Levine, Zebulon G.; Fei, George Q.; Haggarty, Stephen J.; Walker, Suzanne
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Saint Olaf College; Stanford University; Massachusetts Institute of Technology (MIT); Whitehead Institute
摘要：O - GlcNAc transferase (OGT) is an essential mammalian enzyme that glycosylates myriad intracellular proteins and cleaves the transcriptional coregulator Host Cell Factor 1 to regulate cell cycle processes. Via these catalytic activities as well as noncatalytic protein- protein interactions, OGT maintains cell homeostasis. OGT's tetratricopeptide repeat (TPR) domain is important in substrate recognition, but there is little information on how changing the TPR domain impacts its cellular functi...
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作者：Waldfogel, Hannah B.; Dittmann, Andrea G.; Birnbaum, Hannah J.
作者单位：Princeton University; Emory University; Washington University (WUSTL)
摘要：A representative democracy requires citizens to be politically engaged; however, a substantial portion of eligible United States voters do not vote. While structural (e.g., ease or difficulty of voting) and individual (e.g., political efficacy, civic knowledge) factors contribute to (a lack of) turnout, the present work adopts a sociocultural perspective to investigate an additional contributor: how people construe-or make sense of-the duty to vote. We examine whether, and for whom, construing...
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作者：An, Zhichao; Yang, Yi; Yang, Xue; Ma, Wenqi; Jiang, Wei; Li, Yajuan; Chen, Guangfeng; Zhang, Weifeng; Zhuang, Minghao; Wang, Chong; Zhang, Fusuo
作者单位：China Agricultural University; China Agricultural University; Chongqing University; Henan Agricultural University; Hebei Agricultural University
摘要：Transforming smallholder farms is critical to global food security and environmental sustainability. The science and technology backyard (STB) platform has proved to be a viable approach in China. However, STB has traditionally focused on empowering smallholder farmers by transferring knowledge, and wide-scale adoption of more sustainable practices and technologies remains a challenge. Here, we report on a long-term project focused on technology scale-up for smallholder farmers by expanding an...
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作者：Eren, Elif; Watts, Norman R.; Conway, James F.; Wingfield, Paul T.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Encapsulins are protein nanocompartments that regulate cellular metabolism in several bacteria and archaea. Myxococcus xanthus encapsulins protect the bacterial cells against oxidative stress by sequestering cytosolic iron. These encapsulins are formed by the shell protein EncA and three cargo proteins: EncB, EncC, and EncD. EncB and EncC form rotationally symmetric decamers with ferroxidase centers (FOCs) that oxidize Fe +2 to Fe +3 for iron storage in mineral form. However, the structure and...
