2024

最新文章

• The mitochondrial enzyme pyruvate carboxylase restricts pancreatic β- cell senescence by blocking p53 activation AI翻译
  作者：Yang, Yumei; Wang, Baomin; Dong, Haoru; Lin, Huige; Ho, Melody Yuen-man; Hu, Ke; Zhang, Na; Ma, Jing; Xie, Rong; Cheng, Kenneth King-yip; Li, Xiaomu
  作者单位：Fudan University; Fudan University; Hong Kong Polytechnic University; Hong Kong Polytechnic University
  摘要：Defective glucose- stimulated insulin secretion (GSIS) and (3- cell senescence are hallmarks in diabetes. The mitochondrial enzyme pyruvate carboxylase (PC) has been shown to promote GSIS and (3- cell proliferation in the clonal (3- cell lines, yet its physiological relevance remains unknown. Here, we provide animal and human data showing a role of PC in protecting (3- cells against senescence and maintaining GSIS under different physiological and pathological conditions. (3- cell- specific de...
• Bacterial spore surface nanoenvironment requires a AAA plus ATPase to promote MurG function AI翻译
  作者：Delerue, Thomas; Updegrove, Taylor B.; Chareyre, Sylvia; Anantharaman, Vivek; Gilmore, Michael C.; Jenkins, Lisa M.; Popham, David L.; Cava, Felipe; Aravind, L.; Ramamurthi, Kumaran S.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Division of Intramural Research (DIR); Umea University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Virginia Polytechnic Institute & State University
  摘要：Bacillus subtilis spores are produced inside the cytosol of a mother cell. Spore surface assembly requires the SpoVK protein in the mother cell, but its function is unknown. Here, we report that SpoVK is a sporulation- specific, forespore- localized putative chaperone from a distinct higher- order clade of AAA+ ATPases that promotes the peptidoglycan glycosyltransferase activity of MurG during sporulation, even though MurG does not normally require activation during vegetative growth. MurG red...
• We need to understand when not if generative AI can enhance personalized persuasion AI翻译
  作者：Teeny, Jacob D.; Matz, Sandra C.
  作者单位：Northwestern University; Columbia University
• Self- views converge during enjoyable conversations AI翻译
  作者：Welker, Christopher; Wheatley, Thalia; Cason, Grace; Gorman, Catherine; Meyer, Meghan
  作者单位：Dartmouth College; The Santa Fe Institute; Columbia University
  摘要：Based on current research, it is evident that the way people see themselves is shaped by their conversation partners. Historically, this literature focuses on how one individual's expectations can shape another person's self- views. Given the reciprocal nature of conversation, we wondered whether conversation partners' self- views may mutually evolve. Using four- person round- robin conversation networks, we found that participants tended to have more similar self- views post- conversation tha...
• SARS-CoV-2 requires acidic pH to infect cells AI翻译
  作者：Kreutzberger, Alex J. B.; Sanyal, Anwesha; Saminathan, Anand; Bloyet, Louis-Marie; Stumpf, Spencer; Liu, Zhuoming; Ojha, Ravi; Patjas, Markku T.; Geneid, Ahmed; Scanavachi, Gustavo; Doyle, Catherine A.; Somerville, Elliott; Correia, Ricardo Bango Da Cunha; Di Caprio, Giuseppe; Toppila-Salmi, Sanna; Makitie, Antti; Kiessling, Volker; Vapalahti, Olli; Whelan, Sean P. J.; Balistreri, Giuseppe; Kirchhausen, Tom
• Dramatic droplet deformation through interfacial particles jamming AI翻译
  作者：Shang, Luoran; Xu, Ke; Lu, Peter J.; Abbaspourrad, Alireza; Zhao, Yuanjin; Weitz, David A.
  作者单位：Harvard University; Fudan University; Peking University; Harvard University; Cornell University; Southeast University - China; Nanjing University; Harvard University
  摘要：Droplets of one fluid in a second, immiscible fluid are typically spherical in shape due to the interfacial tension between the two fluids. Shear forces can lead to droplet deformation when they are subjected to flow, and these effects can be further modified when the droplet is stabilized by a surfactant due to a flow- induced gradients in the surfactant concentration. An alternative method of stabilizing droplets is through the use of colloidal particles, whose stabilization behavior is intr...
• Knot data analysis using multiscale Gauss link integral AI翻译
  作者：Then, Li; Feng, Hongsong; Li, Fengling; Lei, Fengchun; Wu, Jie; Wei, Guo-Wei
  作者单位：Michigan State University; Dalian University of Technology; Michigan State University; Michigan State University
  摘要：In the past decade, topological data analysis has emerged as a powerful algebraic topology approach in data science. Although knot theory and related subjects are a focus of study in mathematics, their success in practical applications is quite limited due to the lack of localization and quantization. We address these challenges by introducing knot data analysis (KDA), a paradigm that incorporates curve segmentation and multiscale analysis into the Gauss link integral. The resulting multiscale...
• Make it or break it: Protein homeostasis in the synaptonemal complex AI翻译
  作者：Kursel, Lisa E.; Rog, Ofer
  作者单位：Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah
• Toward defining the Anthropocene onset using a rapid increase in anthropogenic fingerprints in global geological archives AI翻译
  作者：Kuwae, Michinobu; Yokoyama, Yusuke; Tims, Stephen; Froehlich, Michaela; Fifield, L. Keith; Aze, Takahiro; Tsugeki, Narumi; Doi, Hideyuki; Saito, Yoshiki
  作者单位：Ehime University; University of Tokyo; Australian National University; Matsuyama University; Kyoto University; Shimane University; National Institute of Advanced Industrial Science & Technology (AIST)
  摘要：One of the remaining issues regarding the Anthropocene is the lack of stratigraphic evidence indicating when the cumulative human pressure from the early Holocene began to fundamentally change the Earth system. Herein, we compile anthropogenic fingerprints from various high-precision-dated proxy records for 137 global sites to determine the age of the unprecedented surge in these records over the last 7700 y. The cumulative number of fingerprints revealed an unprecedented surge in diverse anth...
• Increasing benefits in one-time public goods does not promote cooperation AI翻译
  作者：Struwe, Natalie; Blanco, Esther; Walker, James M.
  作者单位：University of Innsbruck; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
  摘要：The long tradition of research on cooperation includes a well-established finding that individuals respond to the degree of conflict between self-and collective interests (that is, the relative benefits from cooperation) in providing public goods. Existing empirical evidence builds upon settings where participants make multiple decisions or strategically consider alternative scenarios. Here, we consider a decision setting where participants face a one-time (single-decision) setting. One-time c...